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List of works by Robert C Tuckey

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

scientific article published on 31 August 2017

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

scientific article

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

scientific article

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

scientific article

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo

scientific article published on 7 January 2013

A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.

scientific article published on 9 June 2015

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

scientific article published on 20 October 2017

Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice

scientific article

An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

scientific article published on July 2006

Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation

scientific article published on 24 March 2015

Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer

scientific article published on 19 November 2020

Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes

scientific article published on 11 August 2016

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.

scientific article

CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.

scientific article

CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.

scientific article published on 13 February 2018

Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes

scientific article published on 27 March 2019

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

scientific article published on 12 September 2017

Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.

scientific article

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.

scientific article published on 11 June 2010

Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts

scientific article published on 6 October 2015

Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

scientific article published on 21 April 2012

Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

scientific article published in August 2017

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

scientific article

Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation

scientific article

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes ⬇️

scientific article published on August 2, 2012

Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

scientific article published on 20 March 2012

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey

scientific article published on 02 June 2020

Detection of Serotonin, Melatonin, and Their Metabolites in Honey

scientific article published on 20 August 2021

Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.

scientific article

Differential and Overlapping Effects of 20,23(OH)₂D3 and 1,25(OH)₂D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)₂D3

article

Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.

scientific article

Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode

scientific article (publication date: April 2003)

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

scientific article published on 28 September 2016

Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

scientific article

Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.

scientific article published on 28 August 2012

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

scientific article

Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.

scientific article published on 21 November 2011

Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.

scientific article published on 9 March 2016

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

scientific article published on March 2013

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

scientific article published on 09 December 2020

In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1 ⬇️

scientific article published on June 8, 2012

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.

scientific article published on 29 December 2013

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

scientific article published on 24 January 2018

Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway

scientific article published on 25 June 2014

Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.

scientific article published on 20 May 2008

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

scientific article

Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins

scientific article published on 22 July 2016

Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1

scientific article

Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes

scientific article

Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

scientific article published on 30 December 2008

Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.

scientific article

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

scientific article published on 26 December 2016

Novel activities of CYP11A1 and their potential physiological significance.

scientific article published on 13 November 2014

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

scientific article

Novel vitamin D photoproducts and their precursors in the skin.

scientific article published on January 2013

On the role of classical and novel forms of vitamin D in melanoma progression and management

scientific article

On the role of skin in the regulation of local and systemic steroidogenic activities.

scientific article

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

scientific article

Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase

scientific article (publication date: June 2002)

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

scientific article

Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.

scientific article published on 14 July 2017

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

scientific article

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

scientific article

Role of CYP27A1 in progesterone metabolism in vitro and in vivo

scientific article published on 11 August 2009

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

scientific journal article

Side-chain specificities of human and bovine cytochromes P-450scc

scientific article published on 01 October 1993

Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.

scientific article published on 12 April 2016

The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane

scientific article published in October 2003

The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta

scientific article published on 01 July 1999

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

scientific article published on August 2005

The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration

scientific article published in November 2002

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

scientific article published on 28 October 2013

The serum vitamin D metabolome: What we know and what is still to discover

scientific article published on 08 September 2018

Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

scientific article published on 7 October 2002

Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.

scientific article

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

scientific article published on 25 February 2019

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

scientific article published on 13 April 2021

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes

scientific article

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.

scientific article published on 20 February 2017

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