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List of works by Christina L.L. Chai

3-Deazaneplanocin A and neplanocin A analogues and their effects on apoptotic cell death.

scientific article published on 15 October 2014

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

scientific article

A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents

article

A fluorescence-displacement assay using molecularly imprinted polymers for the visual, rapid, and sensitive detection of the algal metabolites, geosmin and 2-methylisoborneol

scientific article published on 20 March 2019

A one step method for the functional and property modification of DOPA based nanocoatings

scientific article

A synthetic approach to chrysophaentin F

scientific article published on 01 April 2019

An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities

scientific article published on 6 November 2015

Atmospheric pressure aminocarbonylation of aryl iodides using palladium nanoparticles supported on MOF-5.

scientific article

Bidentate inhibitors of protein tyrosine phosphatases.

scientific article published on 08 January 2014

CLEVER: pipeline for designing in silico chemical libraries.

scientific article

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

scientific article published on 19 December 2014

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.

scientific article published on 28 June 2012

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

scientific article published on 16 August 2011

Controlled polymerization and self-assembly of a supramolecular star polymer with a guanosine quadruplex core

scientific article published on 27 May 2009

Copper-catalyzed oxidative amidation of aldehydes with amine salts: synthesis of primary, secondary, and tertiary amides

scientific article published on 30 August 2012

Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core

scientific article

Diallyl tartrate as a multifunctional monomer for bio-polymer synthesis.

scientific article

Direct Evidence for the Critical Role of 5,6-Dihydroxyindole in Polydopamine Deposition and Aggregation

scientific article published on 04 April 2019

Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material.

scientific article published in January 2010

Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta.

scientific article

Evidence for gliotoxin-glutathione conjugate adducts.

scientific article

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

scientific article

Friedel-Crafts acylation and metalation strategies in the synthesis of calothrixins A and B.

scientific article published in November 2003

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)

scientific article

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2<i>H</i>-Chromenes

scientific article published on 30 November 2020

Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.

scientific article published on 21 October 2015

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

scientific article published on 01 August 2000

Influencing the Fate of Cardiac and Neural Stem Cell Differentiation Using Small Molecule Inhibitors of ALK5

scientific article published on 31 July 2018

Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins.

scientific article

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development.

scientific article published on 26 October 2015

Mimics of pramanicin derived from pyroglutamic acid and their antibacterial activity.

scientific article published on 7 February 2017

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

scientific article

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

scientific article published on 28 January 2015

One size does not fit all: Challenging some dogmas and taboos in drug discovery.

scientific article published on 21 December 2015

One-Pot UV-Triggered o-Nitrobenzyl Dopamine Polymerization and Coating for Surface Antibacterial Application.

scientific article published on 23 November 2016

Organic polymer composites as robust, non-covalent supports of metal salts

scientific article published on 25 August 2009

Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones

scientific article published on 23 November 2015

PolyPEGA with predetermined molecular weights from enzyme-mediated radical polymerization in water.

scientific article

Polypharmacology of andrographolide: beyond one molecule one target

scientific article published on 06 October 2020

Promoting GAINs (Give Attention to Limitations in Assays) over PAINs Alerts: no PAINS, more GAINs

scientific article published in 2022

Scope of direct arylation of fluorinated aromatics with aryl sulfonates

scientific article published on 21 February 2012

Searching for "environmentally-benign" antifouling biocides

scientific article

Self-supported chiral titanium cluster (SCTC) as a robust catalyst for the asymmetric cyanation of imines under batch and continuous flow at room temperature

scientific article published on 21 March 2012

Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

scientific article

Structure-activity delineation of quinones related to the biologically active Calothrixin B

scientific article published on 04 October 2006

Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity.

scientific article

Synthesis of mimics of pramanicin from pyroglutamic acid and their antibacterial activity.

scientific article published on 23 February 2015

Synthesis of neplanocin A and its 3'-epimer via an intramolecular Baylis-Hillman reaction.

scientific article published on 25 August 2014

Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.

scientific article published in September 2004

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles.

scientific article published on 24 September 2015

The Chemistry of Bioinspired Catechol(amine)-Based Coatings

scientific article published on 29 May 2019

The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent

scientific article published on 16 April 2019

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

scientific article

Total synthesis of (+/-)-cordypyridones A and B and related epimers

scientific article published on 01 December 2009

Transparent, flexible and highly conductive ion gels from ionic liquid compatible cyclic carbonate network.

scientific article published on 6 January 2010

Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells ⬇️

scientific article published on April 4, 2013

Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS.

scientific article published in October 2016

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