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List of works by Barbara Wiśniowska

Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.

scientific article

An Open-Access Dataset of Thorough QT Studies Results

scientific article published on 25 January 2020

BDTcomparator: a program for comparing binary classifiers.

scientific article published on 13 October 2011

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

scientific article published on 24 May 2019

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 18 December 2020

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

scientific article

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges

scientific article

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

scientific article published on 20 March 2022

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

scientific article published on 16 November 2017

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

scientific article

Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study

scientific article published on 15 March 2018

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

scientific article published on 5 May 2015

Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents

scientific article published on 05 January 2015

Evaluation of patients’ adherence to statins in Poland ⬇️

scientific article published on November 24, 2010

Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems

scientific article published on 13 October 2020

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

scientific article published on 26 May 2015

From probiotics to psychobiotics - the gut-brain axis in psychiatric disorders

scientific article published on 16 November 2020

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study

scientific article published in June 2021

How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction

scientific article

Humans Vary, So Cardiac Models Should Account for That Too!

scientific article

In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.

scientific article published on 16 October 2013

Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics

scientific article published in April 2021

Prediction of the hERG potassium channel inhibition potential with use of artificial neural networks

scientific article published in March 2011

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

scientific article

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

scientific article published on 4 January 2018

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

scientific article published on 27 November 2017

Slow delayed rectifying potassium current (IKs ) - analysis of the in vitro inhibition data and predictive model development.

scientific article

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation

scientific article

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm

scientific article published on 13 May 2017

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

scientific article

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.

scientific article published on 14 March 2018

Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

scientific article

Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example

scientific article published on 15 September 2016

Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine

scientific article published on 11 July 2018

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

scientific article published in January 2012

hERG in vitro interchange factors--development and verification

scientific article published on 01 May 2009

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