Search filters

List of works by Melissa Fishel

APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival

scientific article

APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.

scientific article published in January 2012

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.

scientific article published on 23 May 2017

Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics

scientific article published on 12 February 2016

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.

scientific article

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

scientific article published in Scientific Reports

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells.

scientific article published on 26 September 2016

Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models

scientific article published on 03 December 2020

DNA repair in neurons: so if they don't divide what's to repair?

scientific article published on August 2006

DNA repair proteins as molecular targets for cancer therapeutics

scientific article published on May 2008

Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening

scientific article published in Scientific Reports

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.

scientific article

Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.

scientific article published on 15 October 2009

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

scientific article published on 06 March 2019

Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth

scientific article

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis ⬇️

scientific article published on September 6, 2010

Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

scientific article

LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data

scientific article published on 01 October 2019

Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice

scientific article

Loss of MTSS1 results in increased metastatic potential in pancreatic cancer

scientific article published on 27 January 2017

Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

scientific article published on January 2007

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells

scientific article

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition.

scientific article

Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

scientific article published on 06 November 2020

Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.

scientific article published on November 2010

Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization

scientific article published on 03 August 2018

Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.

scientific article published on 26 April 2017

Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models

scientific article published on 17 August 2016

Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

scientific article published on 21 September 2020

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions

scientific article published on September 2009

Role of GADD34 in modulation of cisplatin cytotoxicity

scientific article published on December 2005

Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.

scientific article published on 2 October 2004

Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1

scientific article published on November 2008

STAT3 in the systemic inflammation of cancer cachexia.

scientific article published on 6 February 2016

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.

scientific article published on 10 January 2014

Targeting DNA repair pathways for cancer treatment: what's new?

scientific article

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

scientific article

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer

scientific article

Paulina is supported by:

About Paulina

Help