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List of works by Miguel F Segura

A High-Throughput Screening Identifies MicroRNA Inhibitors That Influence Neuronal Maintenance and/or Response to Oxidative Stress

scientific article published on 20 June 2019

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures

scientific article published on 17 October 2019

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer

scientific article published on 06 April 2020

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs

scientific article published in October 2008

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy

scientific article

BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways

scientific article published on 21 March 2016

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models

scientific article published on 16 July 2020

Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis.

scientific article published on 5 January 2017

FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.

scientific article published on December 2013

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system

scientific article published on 6 July 2016

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma

scientific article published on 15 February 2019

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

scientific article published on 24 January 2017

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo

scientific article

Histology-Specific MicroRNA Alterations in Melanoma ⬇️

scientific article published on May 3, 2012

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

scientific article published on 4 June 2015

Identification of metastasis-suppressive microRNAs in primary melanoma

scientific article

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways

scientific article published on 02 April 2019

Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.

scientific article

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

scientific article

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

scientific article

Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer

scientific article published on 06 November 2019

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness

scientific article

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

scientific article published on 5 December 2017

Methodological advances in the discovery of novel neuroblastoma therapeutics

scientific article published on 22 November 2021

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

scientific article

MicroRNA and cutaneous melanoma: from discovery to prognosis and therapy ⬇️

scientific article published on June 12, 2012

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

scientific article published on 20 December 2016

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells.

scientific article published on 7 September 2017

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.

scientific article

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

scientific article published on 25 January 2016

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways

scientific article published on 05 July 2019

Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f

scientific article published on 2 September 2014

Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.

scientific article published in March 2003

Nuevas estrategias terapéuticas para el neuroblastoma basadas en el uso de microRNAs

scientific article published on 29 August 2015

Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry

scientific article published on 22 August 2014

Patient-derived xenografts for childhood solid tumors: a valuable tool to test new drugs and personalize treatments.

scientific article published on 07 October 2016

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

scientific article published on 15 December 2006

Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation

scientific article published on 2 March 2006

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

scientific article published on 03 February 2020

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.

scientific article

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.

scientific article published on 19 March 2015

Targeting of epigenetic regulators in neuroblastoma.

scientific article published on 27 April 2018

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

publication published on 26 May 2021

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

scientific article published on 13 May 2020

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis

scientific article published on 17 September 2020

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

scientific journal article

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins

scientific journal article

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8 ⬇️

scientific article published on December 23, 2010

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.

scientific article published in October 2007

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

scientific article (publication date: 2011)

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

scientific article published on July 2011

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

scientific article published on 26 October 2017

microRNAs as pharmacological targets in cancer.

scientific article published on 25 March 2013

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