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List of works by E. Dale Abel

A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

scientific article

A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance.

scientific article published on 19 April 2013

A new twist in the function of the cardiac lipid droplet ⬇️

scientific article published on 07 September 2011

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

scientific article published on April 2016

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

scientific article (publication date: November 2006)

Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia

scientific article published on 23 November 2012

Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

scientific article published on 4 October 2017

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

scientific article (publication date: 8 February 2001)

Airway epithelial regeneration requires autophagy and glucose metabolism

scientific article published on 20 November 2019

An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.

scientific article

An unliganded thyroid hormone receptor causes severe neurological dysfunction

scholarly article

Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome ⬇️

scientific article

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

scientific article published on 24 March 2016

Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.

scientific article

Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.

scientific article published on 30 November 2012

Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor

scientific article published on 01 March 2000

Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling

scientific article published on 06 September 2007

Cardiac metabolism in heart failure: implications beyond ATP production.

scientific article published on August 2013

Cardiac remodeling in obesity.

scientific article

Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.

scientific article published on 25 March 2011

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

scientific article published on 30 May 2008

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex

scientific article

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.

scientific article

Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.

scientific article published on April 2009

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

scientific article published on 23 June 2020

Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems

scientific article published on 28 March 2019

Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.

scientific article

Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts

scientific article published on 26 January 2018

Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.

scientific article published on 10 October 2005

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

scientific article published on 23 February 2009

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

scientific article published on 2 April 2009

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

scientific article published on 01 January 2019

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training.

scientific article published on 3 October 2012

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

scientific article published on 30 August 2017

Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice

scientific article published on 9 January 2012

DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

scientific article published on 01 August 2017

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice

scientific article published on 06 December 2013

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

scientific article published on July 2017

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

scientific article published in November 2017

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

scientific article published in August 2017

Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.

scientific article published on 28 March 2018

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice

scientific article

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

scientific article published on 16 April 2018

Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.

scientific article published in June 2006

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.

scientific article published on 21 December 2007

Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin

scientific journal article

Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else?

scientific article published on 01 July 2018

Endonuclease G: the link between mitochondria and cardiac hypertrophy?

scientific article published on 01 February 2012

Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

scientific article published on 8 June 2009

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

scientific article published on December 2011

Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.

scientific article

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.

scientific article published in June 2017

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

scientific article

Exercise training improves vascular mitochondrial function.

scientific article published on 29 January 2016

Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia ⬇️

scientific article published on May 26, 2011

Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice.

scientific article

Free fatty acid oxidation in insulin resistance and obesity ⬇️

scientific article published on September 1, 2010

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

scientific article published on 22 March 2021

GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.

scientific article

Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart

scientific article

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

scientific article published on 9 February 2012

Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes

scientific article published on 14 February 2019

Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.

scientific article published on 29 June 2017

Glucose for the aging heart?

scientific article published on 01 August 2007

Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

scientific article published in Nature Communications

Glucose metabolism is linked to the inflammatory status of macrophages.

scientific article published in June 2012

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

scientific article published on 6 November 2014

Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.

scientific article published on 19 August 2017

HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice ⬇️

scientific article published on January 1, 2012

Heart Failure in Type 2 Diabetes Mellitus

scientific article published on 01 January 2019

Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis

scientific journal article

Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism

scientific article

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

scientific article

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

scientific article

Increased glycolysis mediates Wnt7b-induced bone formation

scientific article published on 26 March 2019

Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.

scientific article published on 19 September 2013

Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5

scientific article

Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. ⬇️

scientific article published on 4 November 2016

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

scientific article published on 7 July 2015

Insulin Signaling and Heart Failure.

scientific article

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

scientific article published on 15 August 2016

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

scientific article

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.

scientific article published on November 2013

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

scientific article

Insulin regulation of myocardial autophagy.

scientific article

Insulin resistance: metabolic mechanisms and consequences in the heart.

scientific article published on September 2012

Insulin signaling in heart muscle: lessons from genetically engineered mouse models.

scientific article

Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway

scientific article published on 05 September 2013

Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.

scientific article published on 30 August 2013

Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4.

scientific article

Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. ⬇️

scientific article

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

scientific article

Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

scientific article

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

scientific article

Lipids, lysosomes, and autophagy.

scientific article published on 21 June 2016

Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.

scientific article

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

scientific article published on 30 April 2019

Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

scientific article

Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.

scientific article published on 12 January 2006

MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE

scientific article published on 01 January 2018

Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.

scientific article

Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.

scientific article

Mechanisms of Lipotoxicity in the Cardiovascular System ⬇️

scientific article published on December 1, 2012

Mechanisms of leucocyte sodium influx in essential hypertension

scientific article published on 01 November 1988

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

scientific article

Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.

scientific article published on September 1998

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

scientific article published on 08 May 2003

Mitochondria in the diabetic heart

scientific article

Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

scientific article

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission.

scientific article published in November 2017

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy ⬇️

scientific article published on January 21, 2011

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

scientific article

Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations

scientific article published on 26 January 2008

Mitochondrial pyruvate carriers are required for myocardial stress adaptation

scientific article published on 26 October 2020

Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

scientific article published on August 2006

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells

scientific article published on 21 November 2018

Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

scientific article

Modulation of the cardiovascular system by leptin.

scientific article published on 02 April 2012

Molecular mechanisms of diabetic cardiomyopathy.

scientific article published on 30 January 2014

Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.

scientific article published on 27 June 2005

Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

scientific article published on 18 January 2019

Myocardial insulin resistance and cardiac complications of diabetes.

scientific article

Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.

scientific article

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes ⬇️

scientific article published on January 27, 2012

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

scientific article published on 10 October 2016

Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation.

scientific article published on 21 December 2017

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.

scientific article

Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth.

scientific article

OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

scientific article published on 12 June 2017

Obesity Stresses Cardiac Mitochondria Even When You Are Young ⬇️

scientific article published on 01 February 2011

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis ⬇️

scientific article published on July 13, 2011

PAS kinase is required for normal cellular energy balance

scientific journal article

PGC-1 proteins and heart failure

scientific article

PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy ⬇️

scientific article published on July 28, 2011

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

article published in 2010

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

scientific article

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

scientific article

Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations

scientific article

Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.

scientific article published on 07 October 2013

Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats.

scientific article published on 28 June 2018

Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation

scientific article published on 18 November 2020

Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation ⬇️

scientific article published in February 2012

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

scientific article

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

scientific article published on 26 April 2013

Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes.

scientific article

Rodent models of diabetic cardiomyopathy.

scientific article published on September 2009

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

scientific article published on 24 April 2017

SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

scientific article published on 15 September 2020

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

scientific article published on 24 January 2017

Solid Phase Synthesis of Mitochondrial Triphenylphosphonium-Vitamin E Metabolite Using a Lysine Linker for Reversal of Oxidative Stress ⬇️

scientific article published on January 14, 2013

Spotlight on metabolic remodelling in heart failure

scientific article published on 23 March 2011

Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts

scientific journal article

Superoxide Dismutase 2 is dispensable for platelet function.

scientific article published on 3 August 2017

Systematic Transmission Electron Microscopy‐Based Identification and 3D Reconstruction of Cellular Degradation Machinery

scientific article published in 2023

Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

scientific article

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

scientific article published on April 2004

Targeting myocardial substrate metabolism in heart failure: potential for new therapies

scientific article

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization

scientific article published on 27 December 2013

The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

scientific article published on 20 December 2016

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

scientific article

The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts

scientific article published on 18 August 2011

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

scientific article published on 29 January 2009

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation

scientific article published on 22 September 2018

Time to Look Back and to Look Forward

scientific article published on 01 April 2014

Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

scientific article published on 19 June 2009

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

scientific article published on 04 August 2008

UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.

scientific article

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

scientific article published on 01 August 2019

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