List of works - Mark Searcey

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

scientific article published on 25 September 2017

A polyclonal antibody preparation with Michaelian catalytic properties.

scientific article published on November 1991

A rapid screen for molecules that form duplex to duplex crosslinks in DNA.

scientific article published on 30 August 2013

A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase

scientific article published on 27 November 2019

A small molecule that induces assembly of a four way DNA junction at low temperature.

scientific article

Acridine-decorated cyclometallated gold(iii) complexes: synthesis and anti-tumour investigations

Active targeting of gold nanoparticles as cancer therapeutics

scientific article published on 22 October 2020

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction ⬇️

scientific article published on March 12, 2012

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

Antitumour antibiotics with potent activity against multidrug resistant (MDR) Staphylococcus aureus: a new approach to targeting resistant bacteria

scientific article published on 01 November 2005

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

scientific article published on 01 March 2000

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.

scientific article published on 13 November 2006

Cancer treatments for the new millennium

scientific article published on 01 May 2006

Catalytic antibody activity elicited by active immunisation. Evidence for natural variation involving preferential stabilization of the transition state

scientific article published on 01 May 1993

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

scientific article published on January 2009

Chemistry in Cancer Research: A Vital Partnership

scientific article published on 09 July 2007

Chemistry in cancer research: a vital partnership.

scientific article published in May 2007

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

scientific article published on 01 November 2018

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

scientific article

DNA binding by analogues of the bifunctional intercalator TANDEM.

scientific article published on 3 July 2008

Design and synthesis of a DNA-crosslinking azinomycin analogue.

scientific article published on 5 September 2005

Design and synthesis of threading intercalators to target DNA.

scientific article published on 7 October 2010

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

scientific article

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

scientific article published on October 2005

Duocarmycins--natures prodrugs?

scientific article

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

scientific article published in April 2014

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

scientific article published on 14 June 2015

Identification of selective protein-protein interaction inhibitors using efficient peptide-directed ligand design

scientific article published on 22 March 2019

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

scientific article published on 14 October 2011

Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.

scientific article published on 25 October 2013

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction

scientific article published on 3 March 2018

Polyclonal antibody-catalysed amide hydrolysis ⬇️

scientific article published on June 15, 1992

Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate

scientific article published on 01 August 1990

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

scientific article published in June 2021

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

scientific article published in 2015

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Recent disclosures of clinical drug candidates

scientific article published on 01 April 2008

Resistance in cancer: a target for drug discovery.

scientific article published in September 2004

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

scientific article published on 30 September 2015

Solid-phase synthesis of chlorofusin analogues

scientific article published on 09 June 2007

Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.

scientific article published on December 2003

Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

scientific article published on 01 November 2006

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

scientific article published on November 2006

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

scientific article published on 14 August 2006

Synthesis of small molecules targeting multiple DNA structures using click chemistry

scientific article

Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives

scientific article published on 01 December 1998

Targeting higher-order DNA: beyond the G-quadruplex.

scientific article published on September 2009

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction

scientific article published on April 2009

Truncated azinomycin analogues intercalate into DNA.

scientific article published on February 2005

Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.

scientific article published on 7 March 2016

X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.

scientific article published on December 2006

List of works by Mark Searcey

(C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties.

A polyclonal antibody preparation with Michaelian catalytic properties.

A rapid screen for molecules that form duplex to duplex crosslinks in DNA.

A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase

A small molecule that induces assembly of a four way DNA junction at low temperature.

Acridine-decorated cyclometallated gold(iii) complexes: synthesis and anti-tumour investigations

Active targeting of gold nanoparticles as cancer therapeutics

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction ⬇️

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

Antitumour antibiotics with potent activity against multidrug resistant (MDR) Staphylococcus aureus: a new approach to targeting resistant bacteria

Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.

Cancer treatments for the new millennium

Catalytic antibody activity elicited by active immunisation. Evidence for natural variation involving preferential stabilization of the transition state

Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

Chemistry in Cancer Research: A Vital Partnership

Chemistry in cancer research: a vital partnership.

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties

DNA binding by analogues of the bifunctional intercalator TANDEM.

Design and synthesis of a DNA-crosslinking azinomycin analogue.

Design and synthesis of threading intercalators to target DNA.

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.

Duocarmycins--natures prodrugs?

Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

Identification of selective protein-protein interaction inhibitors using efficient peptide-directed ligand design

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.

Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction

Polyclonal antibody-catalysed amide hydrolysis ⬇️

Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate

Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds

Probing cytochrome P450-mediated activation with a truncated azinomycin analogue

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Recent disclosures of clinical drug candidates

Resistance in cancer: a target for drug discovery.

Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity

Solid-phase synthesis of chlorofusin analogues

Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions.

Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Synthesis of small molecules targeting multiple DNA structures using click chemistry

Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives

Targeting higher-order DNA: beyond the G-quadruplex.

The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction

Truncated azinomycin analogues intercalate into DNA.

Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.

X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.