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List of works by Karen Bush

15-amido erythromycins: synthesis and in vitro activity of a new class of macrolide antibiotics

scientific article published in March 2005

7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors

scientific article published on 12 October 2014

A Meandering Path from Biochemist to Microbiologist

scientific article published on 04 December 2018

A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli

scientific article

A Standard Numbering Scheme for Class C β-Lactamases

scientific article published on 21 February 2020

A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding

scientific article published in June 2003

A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections

scientific article published in March 2008

Activities of ceftobiprole and other beta-lactams against Streptococcus pneumoniae clinical isolates from the United States with defined substitutions in penicillin-binding proteins PBP 1a, PBP 2b, and PBP 2x.

scientific article published on July 2006

Activity of doripenem and comparator beta-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x

scientific article published on 31 January 2008

Activity of imipenem/relebactam against carbapenemase-producing Enterobacteriaceae with high colistin resistance

scientific article published on 01 November 2019

Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin

scientific article published on 9 August 2010

Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa

scientific article published on 4 February 2008

Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacy

scientific article published on April 2007

Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements

scientific article published on 27 June 2006

Author Correction: Interplay between β-lactamases and new β-lactamase inhibitors

scientific article published on 01 July 2019

Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae

scientific article

Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis

scientific article

CAU-1, a subclass B3 metallo-beta-lactamase of low substrate affinity encoded by an ortholog present in the Caulobacter crescentus chromosome.

scientific article

Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

scientific article

Cathelicidin Antimicrobial Peptides with Reduced Activation of Toll-Like Receptor Signaling Have Potent Bactericidal Activity against Colistin-Resistant Bacteria

scientific article published on 20 September 2016

Characterisation of Staphylococcus aureus and Enterococcus faecalis mutants with reduced susceptibility to the investigational oxazolidinone RWJ-416457 ⬇️

scientific article published on September 17, 2010

Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin

scientific article published on 12 November 2007

Comment on: Redefining extended-spectrum -lactamases: balancing science and clinical need

scientific article published on 24 March 2009

Comment on: Resistance gene naming and numbering: is it a new gene or not?

scientific article published on 3 June 2016

Critical analysis of antibacterial agents in clinical development

scientific article published on 09 March 2020

Cross-resistance, relatedness and allele analysis of fluoroquinolone-resistant US clinical isolates of Streptococcus pneumoniae (1998-2000).

scientific article published in July 2003

Detection systems for carbapenemase gene identification should include the SME serine carbapenemase

scientific article published on 04 December 2012

Differential selection of single-step AmpC or efflux mutants of Pseudomonas aeruginosa by using cefepime, ceftazidime, or ceftobiprole

scientific article published on 6 July 2010

Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa

scientific article published on 11 May 2009

Effects of ceftobiprole and oxacillin on mecA expression in methicillin-resistant Staphylococcus aureus clinical isolates

scientific article published on 30 November 2009

Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology ⬇️

scientific article published in January 2004

Effects of the 7-valent pneumococcal conjugate vaccine on U.S. levofloxacin-resistant Streptococcus pneumoniae

scientific article published in September 2008

Epidemiology and risk factors for isolation of Escherichia coli producing CTX-M-type extended-spectrum β-lactamase in a large U.S. Medical Center.

scientific article published on 10 June 2013

Epidemiology of β-Lactamase-Producing Pathogens

scientific article published on 26 February 2020

Forgotten antibiotics: an inventory in Europe, the United States, Canada, and Australia

scientific article published on January 2012

Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria

scientific article published on 12 December 2017

Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem

scientific article published on 2 November 2009

Identification of a dithiazoline inhibitor of Escherichia coli L,D-carboxypeptidase A

scientific article published on November 2005

In memoriam: John P. Quinn, MD.

scientific article published on 12 December 2013

In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides

scientific article published in January 2005

In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases

scientific article published on 20 August 2014

In vitro activity of plazomicin against β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE).

scientific article published in October 2017

In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone

scientific article

In vitro antibacterial activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.

scientific article published on 13 November 2006

In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations.

scientific article published on 22 December 2014

In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline.

scientific article published on 29 June 2016

In vivo activity of ceftobiprole in murine skin infections due to Staphylococcus aureus and Pseudomonas aeruginosa

scientific article

In vivo activity of the pyrrolopyrazolyl-substituted oxazolidinone RWJ-416457.

scientific article published on 09 March 2009

Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999-2003).

scientific article published on 23 January 2006

Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.

scientific article published on 25 June 2007

Interplay between β-lactamases and new β-lactamase inhibitors

scientific article published on 01 May 2019

Investigational antimicrobial agents of 2013.

scientific article

Is it necessary to change the classification of {beta}-lactamases?

scientific article published on 10 May 2005

Molecular correlation for the treatment outcomes in bloodstream infections caused by Escherichia coli and Klebsiella pneumoniae with reduced susceptibility to ceftazidime

scientific article published on 4 December 2001

MurF inhibitors with antibacterial activity: effect on muropeptide levels

scientific article published on 26 May 2009

Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae.

scientific article published in February 2008

Novel antibacterial agents for the treatment of serious Gram-positive infections

scientific article

Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-Substituent

scientific article published in July 2002

Past and Present Perspectives on β-Lactamases

scientific article published on 24 September 2018

Predominance of 23S rRNA mutants among non-erm, non-mef macrolide-resistant clinical isolates of Streptococcus pneumoniae collected in the United States in 1999-2000.

scientific article published on July 2005

Preparation of erythromycin analogs having functional groups at C-15.

scientific article

Prevalence of single mutations in topoisomerase type II genes among levofloxacin-susceptible clinical strains of Streptococcus pneumoniae isolated in the United States in 1992 to 1996 and 1999 to 2000.

scientific article published on January 2002

Publisher Correction: Interplay between β-lactamases and new β-lactamase inhibitors

scientific article published on 01 July 2019

Reply to Furlan et al., "Importance of Sequencing To Determine Functional blaTEM Variants".

scientific article published on 24 April 2017

SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases

scientific article

Selection of hyperproduction of AmpC and SME-1 in a carbapenem-resistant Serratia marcescens isolate during antibiotic therapy.

scientific article

Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives

scientific article

Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives

scientific article published on 03 May 2007

Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides

scientific article published on 30 January 2006

Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-7-yl) quinolones.

scientific article published on 22 July 2009

Synthesis and antibacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics

scientific article published in September 2004

Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes

scientific article published on 01 February 2005

Synthesis and antibacterial activity of C6-carbazate ketolides

scientific article published on 25 September 2006

Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones

scientific article published in December 2003

TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae

scientific article

Tackling antibiotic resistance

scientific article

The Curious Case of TEM-116.

scientific article published on 21 October 2016

The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones

scientific article

Unusual Escherichia coli PBP 3 Insertion Sequence Identified from a Collection of Carbapenem-Resistant Enterobacteriaceae Tested In Vitro with a Combination of Ceftazidime-, Ceftaroline-, or Aztreonam-Avibactam

scientific article published on 30 May 2017

Updated functional classification of beta-lactamases

scientific article

Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF.

scientific article published on January 2006

β-Lactams and β-Lactamase Inhibitors: An Overview

scientific article published on 21 June 2016

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