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List of works by Christophe Rochais

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

scientific article published on 16 May 2019

3D-QSAR and docking studies of selective GSK-3beta inhibitors. Comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands.

scientific article published in May 2005

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential

scientific article published on 19 June 2019

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

scientific article published on 22 April 2019

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.

scientific article published on 25 March 2017

Carbazole derivatives: a promising scenario for breast cancer treatment.

scientific article published on 09 July 2015

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

scientific article

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease

scientific article published on 26 May 2016

Disproportionality analysis in VigiBase® as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

scientific article published on 03 December 2020

Donecopride, a Swiss army knife with potential against Alzheimer's disease

scientific article published on 27 December 2019

Drug repositioning: a brief overview

scientific article published on 17 April 2020

Facing the complexity of Alzheimer's disease

scientific article published on 21 November 2019

First Synthesis of Racemic <i>Trans</i> Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease

scientific article published on 27 December 2020

Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.

scientific article

Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activity

scientific article

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease

scientific article published on 31 July 2019

Intramolecular cyclisation of β-aryl-β-amino acids in the design of novel heterocyclic systems with therapeutic interest: an unfailing source of diversity.

scientific article published on January 2010

Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges

scientific article published on 27 May 2020

Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.

scientific article published on 15 May 2017

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.

scientific article

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

scientific article published on 06 August 2019

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

scientific article published on 31 March 2015

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

scientific article published on 08 November 2018

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment

scientific article published on 11 March 2020

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT<sub>6</sub> receptor antagonist with therapeutic interest in Alzheimer's disease

scientific article published on 03 December 2020

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease

scientific article published on 20 February 2020

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

scientific article published on 16 September 2019

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

scientific article

Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents

scientific article published on 29 September 2006

Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.

scientific article published in December 2004

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.

scientific article published on 25 March 2016

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors

scientific article published on 23 May 2008

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

scientific article published on 03 March 2012

Therapeutic Potential of 5-HT6 Receptor Agonists.

scientific article published on 22 June 2015

Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

scientific article published on 13 May 2020

Tripentones: a promising series of potent anti-cancer agents

scientific article published on May 2009

Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library

scientific article

hERG toxicity assessment: Useful guidelines for drug design

scientific article published on 03 April 2020

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