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List of works by Hubert Hilbi

-Containing Vacuoles Capture PtdIns(4)-Rich Vesicles Derived from the Golgi Apparatus

scientific article published on 11 December 2018

A novel role for neutrophils as critical activators of NK cells

scientific article published on 01 November 2008

A type IV translocated Legionella cysteine phytase counteracts intracellular growth restriction by phytate

scientific article

A uniform cloning platform for mycobacterial genetics and protein production.

scientific article

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.

scientific article published on 2 March 2018

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection

scientific article (publication date: September 2013)

Adrenergic antagonists restrict replication of Legionella

scientific article

Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophila

scientific article

Analysis of Legionella Metabolism by Pathogen Vacuole Proteomics

scientific article published on 01 January 2018

Anchors for effectors: subversion of phosphoinositide lipids by legionella.

scientific article

Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting.

scientific article

Autoinducers act as biological timers in Vibrio harveyi

scientific article

Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection

scientific article

Biosynthesis of the natural fluorophore legioliulin from legionella

scientific article published on 02 July 2013

Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1).

scientific article published on 9 February 2017

Distinct Mycobacterium marinum phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation, and escape to the cytosol

scientific article published on 07 February 2019

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

scientific article published on 24 March 2020

ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.

scientific article published on 23 August 2017

Environmental predators as models for bacterial pathogenesis.

scientific article published on March 2007

Enzymic and genetic basis for bacterial growth on malonate.

scientific article

Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system

scientific article (publication date: 2014)

Evolution and function of bacterial RCC1 repeat effectors

scientific article published on 27 July 2020

Exploring anti-bacterial compounds against intracellular Legionella

scientific article

Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions.

scientific article published in November 2007

Formation of a pathogen vacuole according to Legionella pneumophila: how to kill one bird with many stones.

scientific article published on 13 May 2015

Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking. ⬇️

scientific article published on 24 November 2017

Formation of the Legionella-containing vacuole: phosphoinositide conversion, GTPase modulation and ER dynamics.

scientific article published on 16 August 2017

Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages.

scientific article published on 27 January 2014

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

scientific article

Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.

scientific article published on 27 January 2014

Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.

scientific article

Identification of protective B cell antigens of Legionella pneumophila

scientific article published on 13 June 2012

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.

scientific article published on 5 January 2016

Induction and protective role of antibodies in Legionella pneumophila infection

scientific article published on 01 December 2007

Inflammasome Recognition and Regulation of the Legionella Flagellum

scientific article

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model

scientific article published on 20 July 2017

Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway

scientific article (publication date: December 2015)

Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila.

scientific article published on 03 February 2017

Isolation of Legionella-containing vacuoles by immuno-magnetic separation.

scientific article published in March 2010

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages

scientific article

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

scientific article published on February 2016

Legionella quorum sensing and its role in pathogen-host interactions.

scientific article published on 27 November 2017

Legionella shows a diverse secondary metabolism dependent on a broad spectrum Sfp-type phosphopantetheinyl transferase

scientific article (publication date: 2016)

Legionella spp. outdoors: colonization, communication and persistence.

scientific article published on 21 March 2011

Legionnaires’ Disease

Live cell imaging of phosphoinositide dynamics during Legionella infection

scientific article published on 01 January 2014

Live-cell imaging of phosphoinositide dynamics and membrane architecture during Legionella infection

scientific article published on 28 January 2014

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

scientific article published on 01 January 2004

Macrophage apoptosis in microbial infections.

scientific article published on January 1997

Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group.

scientific article

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB

scientific article

Metabolism of myo-Inositol by Legionella pneumophila Promotes Infection of Amoebae and Macrophages

scientific article published on 10 June 2016

Metabolism of the vacuolar pathogen Legionella and implications for virulence

scientific article

Modulation of phosphoinositide metabolism by pathogenic bacteria.

scientific article published on 24 August 2006

Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

scientific article

Mycobacterium marinum produces distinct mycobactin and carboxymycobactin siderophores to promote growth in broth and phagocytes

scientific article published on 11 February 2020

Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection

scientific article published on 26 January 2011

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

article

Pathogen trafficking pathways and host phosphoinositide metabolism.

scientific article published on 04 February 2009

Pathway analysis using (13) C-glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila.

scientific article published on 21 December 2015

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

scientific article

Phosphorylation signalling through the Legionella quorum sensing histidine kinases LqsS and LqsT converges on the response regulator LqsR.

scientific article

Planktonic replication is essential for biofilm formation by Legionella pneumophila in a complex medium under static and dynamic flow conditions

scientific article

Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase.

scientific article

Purification and proteomics of pathogen-modified vacuoles and membranes

scientific article

Quantitative imaging flow cytometry of Legionella-infected Dictyostelium reveals the impact of retrograde trafficking on pathogen vacuole composition.

scientific article published on 30 March 2018

Quorum sensing controls persistence, resuscitation, and virulence of Legionella subpopulations in biofilms

scientific article published on 19 September 2020

Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery

scientific article published on 27 July 2021

Quorum sensing modulates the formation of virulent Legionella persisters within infected cells

scientific article published on 18 November 2019

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

scientific article

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.

scientific article

Secretive bacterial pathogens and the secretory pathway.

scientific article published on 13 March 2012

Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.

scientific article

Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB

scientific article

Stereochemical course of malonate decarboxylation in Malonomonas rubra

scientific article published in January 1995

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.

scientific article published on 16 November 2017

Studying the fate of non-volatile organic compounds in a commercial plasma air purifier ⬇️

scientific article published on April 22, 2013

Subversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila Effectors

scientific article

Subversion of Host Membrane Dynamics by the Legionella Dot/Icm Type IV Secretion System

scientific article published in January 2017

Subversion of Retrograde Trafficking by Translocated Pathogen Effectors

scientific article published on 25 February 2016

Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions

scientific article

Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection

scientific article published on 16 November 2021

The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule

scientific article published on 14 April 2008

The Legionella effector RidL inhibits retrograde trafficking to promote intracellular replication.

scientific article published on July 2013

The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions

scientific article

The Legionella pneumophila orphan sensor kinase LqsT regulates competence and pathogen-host interactions as a component of the LAI-1 circuit.

scientific article

The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

scientific article published on 15 August 2008

The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.

scientific article

The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group

scientific article

The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii.

scientific article

The autoinducer synthase LqsA and putative sensor kinase LqsS regulate phagocyte interactions, extracellular filaments and a genomic island of Legionella pneumophila

scientific article

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.

scientific article

The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages

scientific article published on December 1997

The large GTPase atlastin controls ER remodeling around a pathogen vacuole

scientific article published on 06 March 2018

The natural alternative: protozoa as cellular models for Legionella infection

scientific article published on January 2014

The pleiotropic Legionella transcription factor LvbR links the Lqs and c-di-GMP regulatory networks to control biofilm architecture and virulence

scientific article published on 22 February 2019

The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization

scientific article published on 29 January 2020

The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila.

scientific article

Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis

scientific article

Update on Legionnaires' disease: pathogenesis, epidemiology, detection and control

scientific article

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