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List of works by Dan Roden

163 Genetic Modifiers in Carriers of the SCN5A E1784K Mutation with Variable Phenotypic Expression - Long QT3 / Brugada Syndrome Overlap Disease

scientific article published on 31 May 2014

2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device

scientific article

A Bayesian method to estimate variant-induced disease penetrance

scientific article published on 22 June 2020

A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping

scientific article published on 01 July 2019

A KCNJ8 mutation associated with early repolarization and atrial fibrillation ⬇️

scientific article published on May 4, 2012

A Missense Variant in PLEC Increases Risk of Atrial Fibrillation

scientific article published in October 2017

A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids.

scientific article published on 12 June 2019

A calcium sensor in the sodium channel modulates cardiac excitability

scientific article

A case study evaluating the portability of an executable computable phenotype algorithm across multiple institutions and electronic health record environments

scientific article published on 01 November 2018

A clinical prediction model to estimate risk for 30-day adverse events in emergency department patients with symptomatic atrial fibrillation

scientific article

A common variant on chromosome 4q25 is associated with prolonged PR interval in subjects with and without atrial fibrillation.

scientific article published on 03 October 2013

A common β1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation.

scientific article published on January 2012

A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records

scientific article

A conceptual model for translating omic data into clinical action

scientific article

A connexin40 mutation associated with a malignant variant of progressive familial heart block type I

scientific article

A genetic framework for improving arrhythmia therapy.

scientific article published on February 2008

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

scientific article published on 12 September 2013

A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record

scientific article

A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation

scientific article

A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

scientific article published on 5 June 2008

A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation

scientific article published on February 2009

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes

scientific article published on 18 November 2011

A memorable experience

scientific article published on 6 October 2007

A multi-stage genome-wide association study of uterine fibroids in African Americans

scientific article

A phenome-wide association study to discover pleiotropic effects of , , and

A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program.

scientific article

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

scientific article

A rate-independent method of assessing QT-RR slope following conversion of atrial fibrillation

scientific article

A retrospective approach to evaluating potential adverse outcomes associated with delay of procedures for cardiovascular and cancer-related diagnoses in the context of COVID-19

scientific article published on 09 December 2020

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

scientific article

A shock in time

scientific article published in November 2007

A structural requirement for processing the cardiac K+ channel KCNQ1.

scientific article

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

scientific article published in Nature Communications

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiolo

scientific article

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death—Executive Summary

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European S

scientific article published on 01 September 2006

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiolog

scientific article published on 25 August 2006

ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiolo

scientific article published in September 2006

ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling

scientific article published on 15 May 2009

Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics

scientific article published on 01 May 2019

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

scientific article published on 5 April 2017

Acute kidney injury risk-based screening in pediatric inpatients: a pragmatic randomized trial

scientific article published on 27 August 2019

Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans

scientific article

Adverse Events Associated with Risperidone Use in Pediatric Patients: A Retrospective Biobank Study

scientific article published on 01 June 2019

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

scientific article

An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition

scientific article published on 16 January 2020

An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records.

scientific article

Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2

scientific article published on 3 March 2015

Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes

scientific article published on 05 August 2019

Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms.

scientific article published on 23 April 2018

Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans

scientific article published on March 2017

Applied pharmacogenomics in cardiovascular medicine

scientific article

Arrhythmia genetics: Not dark and lite, but 50 shades of gray.

scientific article published on 27 April 2018

Arrhythmia pharmacogenomics: methodological considerations.

scientific article published on January 2009

Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family

scientific article

Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records

scientific article

Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records

scientific article published on May 2013

Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study

article published in 2019

Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery

scientific article published on 01 July 2018

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records

scientific article published on January 2016

Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization

scientific article published on 01 January 2020

Association of Pathogenic Variants in Hereditary Cancer Genes With Multiple Diseases

scientific article published on 21 April 2022

Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis

scientific article published on 01 February 2019

Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations

scientific article published in 2019

Atrial Fibrillation Is a Complex Trait: Very Complex

scientific article published on 02 July 2020

Atrial fibrillation and flutter outcomes and risk determination (AFFORD): design and rationale

scientific article

Atrial fibrillation in KCNE1-null mice

scientific article

Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia

scientific article published on 01 April 2020

Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

scientific article

Autonomic tone attenuates drug-induced QT prolongation

scientific article

Azithromycin Causes a Novel Proarrhythmic Syndrome

scientific article published in April 2017

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research

scientific article

Benefit of pre-emptive pharmacogenetic information on clinical outcome

scientific article published on 29 January 2018

Bidirectional ventricular tachycardia and channelopathy ⬇️

scientific article published on October 15, 2003

Biobanks and electronic medical records: enabling cost-effective research

scientific article

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

scientific article published on 22 May 2009

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic ⬇️

scientific article published on June 20, 2012

Brugada-type ECG pattern and extreme QRS complex widening with propafenone overdose

scientific article published on 01 May 2006

Building evidence and measuring clinical outcomes for genomic medicine

scientific article published on 05 August 2019

CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids

scientific article

CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease

scientific article published on 19 July 2019

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies

scientific article

CYP2C19 Phenotype and Risk of Proton Pump Inhibitor-Associated Infections

scientific article published on 07 November 2019

CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease

scientific article

CYP2D6 genotype and adverse events to risperidone in children and adolescents

scientific article published on 19 January 2019

Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications

scientific article published on 12 February 2018

Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes

scientific article published in February 2002

Calmodulin kinase II activity is required for normal atrioventricular nodal conduction

scientific article published in June 2005

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy

scientific article

Candidate gene approach to identifying rare genetic variants associated with lone atrial fibrillation

scientific article published on 10 October 2013

Cardiac ion channels

scientific article

Cardiac potassium channel dysfunction in sudden infant death syndrome

scientific article published on 07 December 2007

Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management

scientific article

Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation

scientific article published on 31 March 2008

Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system

scientific article published in October 2002

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

scientific article

Cardiovascular Pharmacogenomics: Current Status and Future Directions—Report of a National Heart, Lung, and Blood Institute Working Group ⬇️

scientific article published on April 24, 2012

Cardiovascular Toxicities Associated with Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database

scientific article published on 22 May 2020

Cardiovascular Toxicities Associated With Ibrutinib

scientific article published on 01 October 2019

Cardiovascular effects of noncardiovascular drugs

scientific article published on September 2009

Cardiovascular pharmacogenomics

scientific article

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study

scientific article published on 12 November 2018

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

scientific journal article

Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans

scientific article published on 23 February 2012

Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation

scientific article

Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.

scientific article published in February 2018

Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years

scientific article published on 13 March 2018

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes

Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation ⬇️

scientific article published on November 16, 2011

Clinical and Genetic Factors Associated with Cutaneous Squamous Cell Carcinoma in Kidney and Heart Transplant Recipients

scientific article published on May 2015

Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome

scientific article published on 5 March 2003

Cloning and initial characterization of the human cardiac sodium channel (SCN5A) promoter

scientific article

Clopidogrel and the concept of high-risk pharmacokinetics.

scientific article published in April 2009

Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study

scientific article published in October 2009

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Coding variants in and increase risk of atrial fibrillation

scientific article published on 12 June 2018

Coinheritance of long QT syndrome and Kearns-Sayre syndrome

scientific article published on 15 August 2007

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.

scientific article published on 17 February 2017

Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation.

scientific article published on 26 September 2013

Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation

scientific article published on 23 November 2012

Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion ⬇️

scientific article published on February 19, 2013

Common genetic variants and response to atrial fibrillation ablation

scientific article published on 14 February 2015

Common sodium channel promoter haplotype in asian subjects underlies variability in cardiac conduction.

scientific article published on 16 January 2006

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scientific article

Common variants in KCNN3 are associated with lone atrial fibrillation

scientific article

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia

scientific article published on 06 June 2012

Comparison of HLA allelic imputation programs.

scientific article

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart

scientific article

Correction: Enabling Genomic-Phenomic Association Discovery without Sacrificing Anonymity

scientific article published on 18 June 2013

Creation and Validation of an EMR-based Algorithm for Identifying Major Adverse Cardiac Events while on Statins

scientific article published on 07 April 2014

Dantrolene: from better bacon to a treatment for ventricular fibrillation.

scientific article published on 08 January 2014

Data re-identification: societal safeguards

scientific article published on March 2013

Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action

scientific article (publication date: June 2015)

Deep Mutational Scan of an SCN5A Voltage Sensor

scientific article published on 12 January 2020

Deep learning analysis of electrocardiogram for risk prediction of drug-induced arrhythmias and diagnosis of long QT syndrome

scientific article

Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus

scientific article published on 20 May 2002

Defining Phenotypes from Clinical Data to Drive Genomic Research

scientific article published on 01 May 2018

Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data

scientific article

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

scientific article

Desiderata for computable representations of electronic health records-driven phenotype algorithms

scientific article

Development of a System for Postmarketing Population Pharmacokinetic and Pharmacodynamic Studies Using Real-World Data From Electronic Health Records

scientific article published on 11 February 2020

Development of the Cardiac Conduction System as Delineated by minK‐lacZ ⬇️

scientific article published on April 1, 2003

Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development

scientific article published on 18 December 2013

Drug therapy for atrial fibrillation: where do we go from here?

scientific article

Drug-Induced Long QT Syndrome ⬇️

scientific article published on December 1, 2010

Drug-induced arrhythmia: pharmacogenomic prescribing?

scientific article published on 22 October 2012

Drug-induced long QT and torsade de pointes: recent advances

scientific article published on January 2007

Drug-induced torsades de pointes and implications for drug development.

scientific article

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

scientific article published on 03 August 2009

Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)

scientific article

Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial

scientific article published on 10 May 2017

Electronic health record design and implementation for pharmacogenomics: a local perspective

scientific article published on 05 September 2013

Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI).

scientific article published on 7 October 2014

Enabling genomic-phenomic association discovery without sacrificing anonymity

scientific article

Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association

scientific article published on 26 September 2016

Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

scientific article published on 7 September 2020

Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans

scientific article published on 4 October 2017

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scholarly article published in Nature Genetics

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

scientific article published in July 2017

Ethical and practical challenges to studying patients who opt out of large-scale biorepository research

scientific article published on 25 July 2013

Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals.

scientific article

Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record

scientific article

Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects

scientific article published on 01 September 2018

Evaluation of a Novel System to Enhance Clinicians' Recognition of Preadmission Adverse Drug Reactions

scientific article published on 01 April 2018

Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records

scientific article published on 12 October 2016

Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention

scientific article

Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note.

scientific article

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome

scientific article

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Exploiting ion channel structure to assess rare variant pathogenicity

scientific article published on 9 January 2018

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

scientific article published on July 2011

Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers ⬇️

scientific article published on March 21, 2011

Finding a Needle in a QT Interval Big Data Haystack

scientific article

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

scientific article

Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies

scientific article

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

scientific article

Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm

scientific article published on 7 December 2012

Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association

scientific article

Future of antiarrhythmic drugs

scientific article

GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish

article

Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans

scientific article published on 28 March 2013

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

scientific article published on 12 September 2017

Genetic Risk Prediction of Atrial Fibrillation

scientific article published on 28 October 2016

Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation

scientific article published on 14 February 2020

Genetic Susceptibility for COVID-19-Associated Sudden Cardiac Death in African Americans

scientific article published on 04 May 2020

Genetic and clinical risk prediction model for postoperative atrial fibrillation.

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic determinants of response to cardiovascular drugs

scientific article published on May 2012

Genetic determinants of response to warfarin during initial anticoagulation

scientific article

Genetic determinants of risk and survival in pulmonary arterial hypertension

article

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

scientific article published on 05 December 2018

Genetic determinants of variability in warfarin response after the dose-titration phase.

scientific article published on 14 September 2016

Genetic mechanisms of atrial fibrillation: impact on response to treatment

scientific article published on 16 April 2013

Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing

scientific article

Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives

scientific article published in February 2005

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network

scientific article

Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study

scientific article published on 05 June 2013

Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study

scientific article published on 08 July 2013

Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

scientific article

Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias

scientific article

Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery.

scientific article

Genetics and cardiovascular disease: a policy statement from the American Heart Association.

scientific article

Genetics of acquired long QT syndrome

scientific article

Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia

scientific article

Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes

scientific article (publication date: 2013)

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk

scientific article published on 05 March 2013

Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy

scientific article published on June 2015

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol

scientific article published on 23 May 2019

Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy

scientific article published on 26 August 2020

Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records

scientific article published on 17 November 2017

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

scientific article published on 17 December 2017

Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery

scientific article

Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults.

scientific article published on 24 May 2017

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association studies in pharmacogenomics: successes and lessons

scientific article

Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction

scientific article

Genome-wide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the International Clopidogrel Pharmacogenomics Consortium (ICPC)

scientific article published on 30 May 2020

Genome-wide study of resistant hypertension identified from electronic health records

scientific article

Genomic Medicine Year in Review: 2019

scientific article published on 05 December 2019

Genomic Medicine Year in Review: 2020

scientific article published on 01 December 2020

Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data

scientific article

Genomic medicine for undiagnosed diseases

scientific article published on 05 August 2019

Genotype and risk of major bleeding during warfarin treatment

scientific article

Global implementation of genomic medicine: We are not alone

scientific article

Heart failure and atrial tachyarrhythmia on abiraterone: A pharmacovigilance study

scientific article published on 02 November 2019

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network

scientific article published on 15 April 2019

High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE

scientific article

High-Throughput Reclassification of SCN5A Variants

scientific article published on 05 June 2020

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1.

scientific article published on 06 June 2020

How Will Genetics Inform the Clinical Care of Atrial Fibrillation?

scientific article published on 18 June 2020

Human cardiac potassium channel DNA polymorphism modulates access to drug-binding site and causes drug resistance

scientific article published on 14 July 2005

Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography

scientific article published in PLoS ONE

Hypogonadism as a Reversible Cause of Torsades de Pointes in Men

scientific article published on 01 July 2018

I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines ⬇️

scientific article published on October 2, 2003

Identification of Central Regulators of Calcium Signaling and ECM-Receptor Interaction Genetically Associated With the Progression and Recurrence of Atrial Fibrillation.

scientific article

Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science

scientific article

Identification of unique venous thromboembolism-susceptibility variants in African-Americans

scientific article

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

scientific article published on November 2007

Identifying genetically driven clinical phenotypes using linear mixed models

scientific article published on 25 April 2016

Images in cardiovascular medicine. Himalayan T waves in the congenital long-QT syndrome.

scientific article published in March 2005

Implementing Genomic Medicine in the Clinic

Implementing genomic medicine in the clinic: the future is here

scientific article published on 10 January 2013

Improving the phenotype risk score as a scalable approach to identifying patients with Mendelian disease

scientific article published on 01 December 2019

In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia

scientific article

Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article

Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process

scientific article

Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice ⬇️

scientific article published on May 4, 2012

Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors

scientific article published on 02 May 2018

Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT).

scientific article

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel

scientific article

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

scientific article published on 14 October 2020

Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations

scientific article (publication date: 2014)

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes

scientific article published on April 2017

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

scientific article (publication date: 12 October 2016)

KCNH2 pharmacogenomics summary

scientific article published on December 2010

KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome

scientific article published on 22 August 2005

KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road from Identification to Implementation of Culturally Appropriate Precision Medicine

scientific article published on 03 November 2020

Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy

scientific article published on February 2017

Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks

scientific article

LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins

Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation

scientific article published on 13 January 2009

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article

Left atrial hypertension after repeated catheter ablations for atrial fibrillation

scientific article published on 01 May 2011

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use

scientific article published on 28 February 2020

Leveraging the electronic health record to implement genomic medicine

scientific article

Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply

scientific article published in June 2016

Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data

scientific article

Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association

scientific article

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

scientific article published on 29 April 2012

Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study

scientific article published on 19 February 2008

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

scholarly article

Modeling drug exposure data in electronic medical records: an application to warfarin.

scientific article

Modification of proteins by isoketal-containing oxidized phospholipids

scientific article

Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1 ⬇️

scientific article published on November 1, 2010

Modulators of normal electrocardiographic intervals identified in a large electronic medical record

scientific article

Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates

scientific article

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multi-ethnic genome-wide association study for atrial fibrillation

article

Multiple mechanisms underlie increased cardiac late sodium current

scientific article published on 21 January 2019

Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome

scientific article published on 06 January 2015

Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation

scientific article

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant

scientific article

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

scientific journal article

Non-pulmonary vein mediated atrial fibrillation: A novel sub-phenotype.

scientific article published on 7 September 2017

Novel Brugada SCN5A mutation causing sudden death in children

scientific article published on 01 May 2005

Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation

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On the Potential of Preemptive Genotyping Towards Preventing Medication-Related Adverse Events: Results from the South Korean National Health Insurance Database.

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On the relationship among QT interval, atrial fibrillation, and torsade de pointes

scientific article published on September 2007

Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation

scientific article published on 01 April 2018

Opportunities, resources, and techniques for implementing genomics in clinical care

scientific article published on 05 August 2019

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

scientific article published on 28 November 2016

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

Partial Duplication and Poly(A) Insertion in KCNQ1 Not Detected by Next-Generation Sequencing in Jervell and Lange-Nielsen Syndrome

scientific article published on June 2016

Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network

scientific article

Performant Mutation Identification Using Targeted Next-Generation Sequencing of 14 Thoracic Aortic Aneurysm Genes

article

Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome

scientific article published on February 2008

Pharmacogenetics to Predict Adverse Events Associated With Antidepressants

scientific article published on 24 November 2020

Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients

scientific article published on 03 September 2019

Pharmacogenomics

scientific article published on 05 August 2019

Pharmacogenomics and Cardiovascular Disease ⬇️

scientific article published on July 1, 2013

Pharmacogenomics: challenges and opportunities

scientific article published on November 2006

Pharmacogenomics: the genetics of variable drug responses

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Pharmacogenomics: will the promise be fulfilled?

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PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability

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PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records

scientific article published on 24 September 2020

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

scientific article

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

scientific article

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

scientific article

Phenome-wide association studies: a new method for functional genomics in humans

scientific article

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.

scientific article published on May 2017

Phenotype risk scores identify patients with unrecognized Mendelian disease patterns

scientific article published in Science

Phenotype-Driven Plasma Biobanking Strategies and Methods

scientific article published on 14 May 2015

Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery

scientific article published on 11 November 2018

Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population

scientific article

Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions

scientific article published on 30 June 2003

Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass

scientific article published on 01 September 2007

Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis - a phenome-wide association study and inverse-variance weighted meta-analysis

scientific article published on 20 April 2020

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation

scientific article

Polymorphism screening in the cardiac K+ channel gene KCNA5.

scientific article published in March 2005

Polymorphisms in beta-adrenergic receptor genes in the acquired long QT syndrome

scientific article published on 01 March 2002

Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans

scientific article published on 21 June 2016

Practical considerations in genomic decision support: The eMERGE experience

scientific article

Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record

scientific article

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

scientific article published on 01 February 2020

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation

scientific article

Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation

scientific article published on 08 February 2010

Principles of human subjects protections applied in an opt-out, de-identified biobank

scientific article

Probing the Virtual Proteome to Identify Novel Disease Biomarkers

scientific article published on 01 November 2018

Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation

scientific article published on 12 June 2009

Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.

scientific article published on 18 November 2014

Prolonged signal-averaged P-wave duration as an intermediate phenotype for familial atrial fibrillation

scientific article published on March 2008

Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy ⬇️

scientific article published on September 15, 2011

Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds

scientific article published on 9 November 2010

Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve

scientific article published on 01 September 2005

QT variability during initial exposure to sotalol: experience based on a large electronic medical record.

scientific article published on 19 June 2013

Race-Specific Impact of Atrial Fibrillation Risk Factors in Blacks and Whites in the Southern Community Cohort Study ⬇️

scientific article published on August 23, 2012

Rare variants in genes encoding the cardiac sodium channel and associated compounds and their impact on outcome of catheter ablation of atrial fibrillation

scientific article published on 24 August 2017

Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise

scientific article

Real-time clinical note monitoring to detect conditions for rapid follow-up: A case study of clinical trial enrollment in drug-induced torsades de pointes and Stevens-Johnson syndrome

scientific article published on 29 October 2020

Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 20 November 2019

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

scientific article

Refining repolarization reserve ⬇️

scientific article published on June 24, 2011

Relation of morbid obesity and female gender to risk of procedural complications in patients undergoing atrial fibrillation ablation.

scientific article published on 17 November 2012

Relation of the severity of obstructive sleep apnea in response to anti-arrhythmic drugs in patients with atrial fibrillation or atrial flutter

scientific article

Relationship between very low low-density lipoprotein cholesterol concentrations not due to statin therapy and risk of type 2 diabetes: A US-based cross-sectional observational study using electronic health records

scientific article published on 28 August 2018

Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy

scientific article published on 12 December 2008

Replication of Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies

article

Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"

scientific article published on 01 November 2018

Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects

scientific article published on 20 February 2018

Responding to the clopidogrel warning by the US food and drug administration: real life is complicated

scientific article published on 28 June 2010

Response by Salem et al to Letter Regarding Article, "Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes"

scientific article published on 03 February 2020

Risk factor interactions and genetic effects associated with post-operative atrial fibrillation

scientific article published in January 2006

Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current

scientific article published in June 2003

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record

scientific article

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

scientific article published on 17 February 2015

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation

scientific article published on 22 July 2014

SCN5A Mutation Type and a Genetic Risk Score Associate Variably with Brugada Syndrome Phenotype in SCN5A Families

scientific article published on 09 November 2020

SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells

scientific article published on 21 May 2019

SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study.

scientific article

STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION

scientific article

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

scientific article

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

scientific article published on 6 March 2019

Size matters: how population size influences genotype-phenotype association studies in anonymized data

scientific article

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

scientific article

Stem cell-derived cardiomyocytes as a tool for studying proarrhythmia: a better canary in the coal mine?

scientific article published on 21 March 2013

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro

scientific article published on 8 August 2011

Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop

scientific article

Suppression of bidirectional ventricular tachycardia and unmasking of prolonged QT interval with verapamil in Andersen's syndrome

scientific article published in January 2004

Symptomatic burden as an endpoint to evaluate interventions in patients with atrial fibrillation

scientific article published in May 2005

Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

scientific article

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

scientific article

The AFFORD clinical decision aid to identify emergency department patients with atrial fibrillation at low risk for 30-day adverse events.

scientific article

The All of Us Research Program: Data quality, utility, and diversity

scientific article published in 2022

The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome

scientific article published on June 2008

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future ⬇️

scientific article (publication date: October 2013)

The Future of Cardiovascular Therapeutics

scientific article published on June 2016

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes

scientific article published on 02 July 2012

The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias

scientific article

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

scientific article published on 19 March 2013

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

scientific journal article

The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies

scientific article (publication date: 26 January 2011)

The genetic basis of variability in drug responses

scientific article

The influence of big (clinical) data and genomics on precision medicine and drug development.

scientific article published on 24 November 2017

The molecular genetics of arrhythmias

scientific article published on 01 August 2005

The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel

scientific article published on July 2009

The phenotypic legacy of admixture between modern humans and Neandertals

scientific article

The polygenic architecture of left ventricular mass mirrors the clinical epidemiology

scientific article published on 05 May 2020

Transcription factor ETV1 is essential for rapid conduction in the heart

scientific article published on 24 October 2016

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

scientific article published on 20 May 2020

Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.

scientific article published on 2 June 2003

Understanding the use of observational and randomized data in cardiovascular medicine

scientific article published on 04 February 2020

Unmasking of brugada syndrome by lithium

scientific article

Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents

scientific article published on 22 December 2003

Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors

scientific article published on 28 November 2017

Using systems approaches to address challenges for clinical implementation of pharmacogenomics

Using systems approaches to address challenges for clinical implementation of pharmacogenomics.

scientific article published on 06 December 2013

Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients

scientific article published on January 2014

Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality

scientific article

Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome

scientific article published on 01 July 2020

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes

scientific article published on 13 September 2016

Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies

scientific article

Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery

scientific article

Visual integration of results from a large DNA biobank (BioVU) using synthesis-view

scientific article published on January 2011

Voltage-gated sodium channels are required for heart development in zebrafish

scientific article

When good drugs go bad.

scientific article

When should QT be measured? Summer solstice or Christmas Eve?

scientific article published on 06 December 2006

Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy

scientific article published on 16 July 2013

Whole-exome sequencing in familial atrial fibrillation.

scientific article

[Guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Executive summary]

scientific article published on 01 December 2006

eMERGEing progress in genomics-the first seven years

scientific article

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