List of works by Katarzyna Kiec-Kononowicz

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

scientific article published on 10 August 2015

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

scientific article

2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction

scientific article published on 17 August 2018

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity

scientific article published on 20 November 2019

4-tert-Pentylphenoxyalkyl derivatives - Histamine H receptor ligands and monoamine oxidase B inhibitors

scientific article published on 31 October 2018

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria

scientific article published on 26 January 2019

5-arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump.

scientific article published on January 2012

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation

scientific article published on 19 June 2020

A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands

scientific article published on 28 February 2020

Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump.

scientific article

Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands

scientific article published on 12 February 2019

Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria

scientific article published on 01 October 2011

An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells

scientific article published in April 2021

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats

scientific article published on 30 March 2020

Anti-inflammatory, antioxidant, and antiparkinsonian effects of adenosine A2A receptor antagonists.

scientific article

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities

scientific article published on 13 February 2012

Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.

scientific article published on 2 May 2006

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice.

scientific article published on 19 January 2018

Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats

scientific article published on 03 May 2018

Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol

scientific article

Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists.

scientific article published in June 2014

Antimicrobial activity of 5-arylidene aromatic derivatives of hydantoin. Part 2.

scientific article published in January 2002

Antimycobacterial activity of 5-arylidene aromatic derivatives of hydantoin.

scientific article

Antimycobacterial activity of 5-arylidene derivatives of hydantoin.

scientific article

Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain.

scientific article published on 29 October 2016

Antinociceptive effects of novel histamine H3 R and H4 R receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse.

scientific article published on 27 February 2018

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists

scientific article published on 18 November 2010

Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro

scientific article published on 06 December 2019

Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands

scientific article published on 21 June 2017

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

scientific article

Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide

scientific article published on 20 October 2016

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design.

scientific article

Atypical cardiostimulant beta-adrenoceptor in the rat heart: stereoselective antagonism by bupranolol but lack of effect by some bupranolol analogues.

scientific article published in August 2003

Azines and Diazines as Potential Histamine H3‐Receptor Antagonists ⬇️

scientific article published on May 1, 1995

Azines as histamine H4 receptor antagonists

scientific article published on January 2012

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

article

Binding of 1-[3-(4-tert-butyl-phenoxy)propyl]piperidine, a new non imidazole histamine H3 receptor antagonist to bovine serum albumin

scientific article published on 01 November 2012

Biological activity of hydantoin derivatives on P-glycoprotein (ABCB1) of mouse lymphoma cells.

scientific article

Biological activity of twenty-three hydantoin derivatives on intrinsic efflux pump system of Salmonella enterica serovar Enteritidis NCTC 13349.

scientific article published on September 2011

Biotransformation of new racemic (R,S)-5-benzylhydantoin derivatives by D-hydantoinases from adzuki bean

scientific article published in March 2014

Biotransformation of praziquantel by human cytochrome p450 3A4 (CYP 3A4).

scientific article published on September 2006

Biphenylalkoxyamine Derivatives-Histamine H Receptor Ligands with Butyrylcholinesterase Inhibitory Activity

scientific article published on 11 June 2021

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

scientific article published on 29 July 2017

Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18

scientific article

Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.

scientific article published on 2 December 2015

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

scientific article published on 20 April 2016

Comparison of the in vitro hemolytic effects produced by alkoxyacetic acids on human and rat erythrocytes

scientific article published in January 2008

Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

scientific article published on 29 April 2020

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT₆ Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo

scientific article published on 03 October 2018

Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity

scientific article published in February 2018

Convenient way of synthesis and crystal structure of 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, a histamine H4 receptor antagonist

Corrigendum to "Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands" [Eur. J. Med. Chem. 185 (2020) 111785]

scientific article published on 10 August 2020

Crystallographic and spectroscopic studies of 5-arylidene-2-amino-imidazol-4-ones

scientific article published in July 2009

Crystallographic studies of (Z) and (E) isomers of 2-amino-5-(2-chlorobenzylidene)-1-methyl-1H-imidazol-4(5H)-one

scientific article published in March 2010

Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer’s disease

scientific article published in September 2021

Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives

scientific article published on 21 March 2015

Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands.

scientific article published on 30 September 2016

Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides

scientific article published on 23 June 2015

Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists

scientific article published on 11 January 2019

Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity.

scientific article published in February 1999

Development of novel cellular model for affinity studies of histamine H(4) receptor ligands

scientific article published on January 2013

Diether (substituted) piperidine derivatives as novel, histamine H3 receptor ligands.

scientific article published in April 2009

Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands

scientific article

Discovery of Potential, Dual-Active Histamine H Receptor Ligands with Combined Antioxidant Properties

scientific article published on 15 April 2021

Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18

scientific article published on 17 June 2020

Discovery of novel lead in the group of N-substituted piperazine ether derivatives with potential histamine H3 receptor activity.

scientific article published in January 2014

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors ⬇️

scientific article published on 12 May 2020

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity

scientific article published on 02 May 2012

Dual-targeting approach on histamine H3 and sigma-1 receptor ligands as promising pharmacological tools in the treatment of CNS-linked disorders

scientific article published on 05 August 2020

Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating

scientific article published on 16 March 2021

Efflux Pump Blockers in Gram-Negative Bacteria: The New Generation of Hydantoin Based-Modulators to Improve Antibiotic Activity

scientific article

Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1h-indole like derivatives against the human histamine H4 receptor

scientific article published on 02 October 2020

Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists

scientific article published on 8 February 2006

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

scientific article

Five-membered heterocycles. Part III. Aromaticity of 1,3-imidazole in 5+n hetero-bicyclic molecules

article

Flow cytometry application for studies on adenosine A2A receptors expression

scientific article

Fluorescent GPCR ligands as new tools in pharmacology-update, years 2008-early 2014.

scientific article published on January 2014

Fluorescent GPCR ligands as new tools in pharmacology.

scientific article published on January 2008

Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry.

scientific article published on 22 April 2018

Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers

scientific article published on 11 March 2019

Four- and five-coordinate copper(II) complexes with N-(4,4-diphenyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)glycine

scientific article published on 12 January 2008

Fused 2-thiohydantoin derivatives: evaluation as potential antioxidants

scientific article published on 01 April 1997

H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice.

scientific article published on 24 May 2016

Histamine H Receptor Ligands-KSK-59 and KSK-73-Reduce Body Weight Gain in a Rat Model of Excessive Eating

scientific article published on 25 October 2021

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.

scientific article published on 6 October 2009

Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats

scientific article published on 20 February 2019

Histamine H3 receptor ligands in the group of (homo)piperazine derivatives

scientific article published on 23 November 2017

Human eosinophils - potential pharmacological model applied in human histamine H4 receptor research.

scientific article

Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.

scientific article published on 22 April 2016

Imidazo[2,1-b]thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.

scientific article published in March 2004

Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: synthesis, biological evaluation and molecular modeling studies.

scientific article published on 24 June 2015

Impact of the aryl substituent kind and distance from pyrimido[2,1-f]purindiones on the adenosine receptor selectivity and antagonistic properties.

scientific article published in April 2003

In Vitro Effects of Bromoalkyl Phenytoin Derivatives on Regulated Death, Cell Cycle and Ultrastructure of Leukemia Cells.

scientific article

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

scientific article published on 03 November 2020

In silico and in vitro studies on interaction of novel non-imidazole histamine H3R antagonists with CYP3A4

scientific article published on 29 March 2020

In the search for a lead structure among series of potent and selective hydantoin 5-HT7 R agents: The drug-likeness in vitro study.

scientific article published on 8 September 2017

In vitro cytotoxic activity evaluation of phenytoin derivatives against human leukemia cells

scientific article

In vitro study of histamine and histamine receptor ligands influence on the adhesion of purified human eosinophils to endothelium.

scientific article published on 29 February 2016

Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha-Methylhistamine in C57BL/6 Mice

scientific article published on 12 September 2019

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

scientific article published on July 2012

KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice

scientific article published on 18 June 2020

KSK19 - Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice

scientific article published on 08 July 2019

LC-MS-MS Method for the Analysis of New Non-Imidazole Histamine H(3) Receptor Antagonist 1-[3-(4-tert-Butylphenoxy)propyl]piperidine in Rat Serum-Application to Pharmacokinetic Studies

scientific article published on 25 February 2011

Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol

scientific article

MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation

scientific article published on 3 February 2018

MH-3: evidence for non-competitive antagonism towards the low-affinity site of β1-adrenoceptors

scientific article published on 03 May 2014

Metabolic benefits of novel histamine H3 receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties

scientific article published in October 2021

Methods for the synthesis of xanthine-derived polycyclic fused systems

scientific article published in January 2013

Micellar liquid chromatography for lipophilicity determination of new biologically active 1,3-purinodiones.

scientific article published in June 2010

Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis

scientific article published on October 2011

Molecular and electronic structures of two (anticonvulsant) diphenylhydantoin derivatives

scientific article published on 01 February 1994

Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases

scientific article published on 02 June 2018

Molecular modeling of A1 and A2A adenosine receptors: comparison of rhodopsin- and beta2-adrenergic-based homology models through the docking studies

scientific article published in January 2009

Monocyclic and Fused Azines and Azoles as Histamine H₄ Receptor Ligands

scientific article published on 11 April 2016

Multifunctional Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties

scientific article published on 21 September 2017

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands

scientific article published on 24 March 2011

N-substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins

scientific article published on 29 August 2020

N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.

scientific article published on 19 April 2007

Natural selenium particles from Staphylococcus carnosus: Hazards or particles with particular promise?

scientific article published on 2 February 2016

New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

scientific article published on 05 December 2019

New developments around histamine H(3) receptor antagonists/inverse agonists: a patent review (2010 - present).

scientific article published on 17 October 2013

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

scientific article

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

scientific article published on 11 January 2016

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

scientific article published on 02 February 2019

Novel multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.

scientific article published on 31 January 2018

Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.

scientific article published on 11 April 2018

Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain

scientific article published on 14 October 2020

Novel, Dual Target-Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B

scientific article published on 12 March 2020

Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives

scientific article published on 10 November 2018

PSB 603 - a known selective adenosine A2B receptor antagonist - has anti-inflammatory activity in mice

scientific article published on 29 December 2020

Pharmacokinetics and tissue distribution of the new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy) propyl]piperidine in rats.

scientific article

Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors.

scientific article published on 8 July 2017

Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin

scientific article published on 05 December 2010

Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats

scientific article published on 26 May 2017

Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: Structure–activity relationships as adenosine A1 and A2A receptor ligands

scientific article published on 22 August 2007

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis

scientific article published on 20 August 2020

Piperidine variations in search for non-imidazole histamine H(3) receptor ligands.

scientific article

Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

scientific article published on 18 June 2020

Potent adenosine A1 and A2A receptors antagonists: recent developments.

scientific article published on January 2006

Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity.

scientific article published on 26 June 2018

Probing an artificial polypeptide receptor library using a series of novel histamine H3 receptor ligands

scientific article

Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).

scientific article published on 15 January 2018

Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria

scientific article published in 2019

Pyrazoles as potential histamine H3-receptor antagonists

scientific article published on 01 May 1995

Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation

scientific article published on 9 February 2016

Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease

scientific article published on 21 August 2020

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus

scientific article

Recent advances in histamine H3 receptor antagonists/inverse agonists.

scientific article published on September 2010

Role of Histamine H₃ Receptor Antagonists on Intraocular Pressure Reduction in Rabbit Models of Transient Ocular Hypertension and Glaucoma

scientific article published on 24 February 2019

SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.

scientific article published on 18 March 2014

Salsolinol-neurotoxic or Neuroprotective?

scientific article published on 15 November 2019

Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists

scientific article published on 25 September 2018

Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives.

scientific article

Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin

scientific article published on 30 July 2010

Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands

scientific article published on 17 October 2019

Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin.

scientific article published on 15 November 2012

Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.

scientific article published on 8 December 2017

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors

scientific article published on 16 April 2019

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

scientific article

Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism

scientific article published on 28 August 2020

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

scientific article published on 03 May 2011

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands

scientific article published on 20 June 2019

Structural modifications in the distal, regulatory region of histamine H<sub>3</sub> receptor antagonists leading to the identification of a potent anti-obesity agent

scientific article published on 24 November 2020

Structure-activity relationship of some new anti-arrhythmic phenytoin derivatives

scientific article published on 01 November 2000

Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18

scientific article published on 01 June 2018

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats

scientific article published on 29 October 2018

Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.

scientific article published on 27 October 2017

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

scientific article published on 6 August 2015

Synthesis and SAR-study for novel arylpiperazine derivatives of 5-arylidenehydantoin with α₁-adrenoceptor antagonistic properties

scientific article published on 05 June 2012

Synthesis and anticonvulsant evaluation of some N-substituted phthalimides.

scientific article published in May 2009

Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

scientific article

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido-, and diazepinopurinediones

scientific article published on 17 July 2006

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

scientific article

Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6

scientific article published on 10 June 2019

Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT6 serotonin receptor among substituted 1,3,5-triazinylpiperazines

scientific article published on 26 November 2018

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

scientific article published in December 2004

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity.

scientific article published on 9 June 2010

Synthesis of chiral N-protected amino acid esters by the use of UNCAs

Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.

scientific article published on 26 April 2008

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones

scientific article published on 02 April 2013

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

scientific article published in June 2003

Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives

scientific article

Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils

scientific article published in 2017

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment

scientific article published on 12 July 2019

The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies.

scientific article published on 26 April 2016

The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice

scientific article published on 03 June 2020

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

scientific article published on 13 August 2021

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

scientific article published on 12 February 2018

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

scientific article published on 12 October 2017

The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats

scientific article published on 14 November 2019

The Structural Determinants for α-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

scientific article published on 20 November 2021

The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter

The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus

scientific article published on 01 March 2012

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine

scientific article published on 13 April 2017

The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice

scientific article published on 30 July 2019

The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice

scientific article published on 25 May 2018

The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.

scientific article published on 30 August 2018

The lipophilicity estimation of 5-arylidene derivatives of (2-thio)hydantoin with antimycobacterial activity

scientific article

The novel non-imidazole histamine H3 receptor antagonist DL77 reduces voluntary alcohol intake and ethanol-induced conditioned place preference in mice

scientific article published on 10 July 2015

The research on biotransformation of praziquantel

scientific article published in December 2004

The role of aryl-topology in balancing between selective and dual 5-HTR/5-HT actions of 3,5-substituted hydantoins

scientific article published on 08 May 2018

The stereoselectivity and hydrolysis efficiency of recombinant D-hydantoinase from Vigna angularis Against 5-benzylhydantoin derivatives with halogen and methyl substituents.

scientific article published on 24 October 2014

The study of cellular cytotoxicity of argireline - an anti-aging peptide

scientific article published on 17 March 2014

Tricyclic oxazolo[2,3-f]purinediones: potency as adenosine receptor ligands and anticonvulsants.

scientific article published in September 2004

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

scientific article published on 14 May 2018

Unnatural D-amino acids as building blocks of new peptidomimetics

scientific article published on 01 September 2006

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