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List of works by Valentina De Falco

A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure.

scientific article published in October 2004

BRAF is a therapeutic target in aggressive thyroid carcinoma.

scientific article published in March 2006

Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma.

scientific article published on 27 February 2006

CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells ⬇️

scientific article published on January 23, 2012

Calcium/Calmodulin-dependent protein kinase II and its endogenous inhibitor α in medullary thyroid cancer.

scientific article published on 21 January 2014

Cytosolic phospholipase A2 alpha regulates cell growth in RET/PTC-transformed thyroid cells.

scientific article published on December 2007

Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.

scientific article published on 30 October 2009

Effects of combined administration of rapamycin, tolvaptan, and AEZ-131 on the progression of polycystic disease in PCK rats.

scientific article published on 19 March 2014

Functional characterization of the novel T599I-VKSRdel BRAF mutation in a follicular variant papillary thyroid carcinoma.

scientific article

Mitochondrial localization and regulation of BRAFV600E in thyroid cancer: a clinically used RAF inhibitor is unable to block the mitochondrial activities of BRAFV600E.

scientific article published on 6 October 2010

Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.

scientific article published on 21 April 2009

Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

scientific article

Ponatinib (AP24534) Is a Novel Potent Inhibitor of Oncogenic RET Mutants Associated With Thyroid Cancer ⬇️

scientific article published on March 22, 2013

RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

scientific article published on January 2007

Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes

scientific article published in January 2003

The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC.

scientific article

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

scientific article

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

scientific article published on 17 February 2009

The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.

scientific article published on 30 November 2010

XB130 mediates cancer cell proliferation and survival through multiple signaling events downstream of Akt.

scientific article

XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway.

scientific article

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