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List of works by Amaury E Fernández-Montalván

A universal homogeneous assay for high-throughput determination of binding kinetics.

scientific article published on 18 September 2014

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication

scientific article published on 6 September 2016

Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

scientific article published on 04 February 2014

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models

scientific article published on 03 October 2016

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

scientific article

Binding Kinetics Survey of the Drugged Kinome

scientific article published on 06 November 2018

Binding kinetics in drug discovery - A current perspective.

scientific article published on January 2017

Cell-based protein stabilization assays for the detection of interactions between small-molecule inhibitors and BRD4.

scientific article

Characterization of 12 GnRH peptide agonists - a kinetic perspective

scientific article published on 23 September 2015

Concentration dependency of the unbound partition coefficient Kpuu and its application to correct for exposure related discrepancies between biochemical and cellular potency of KAT6A inhibitors

scientific article published on 01 May 2020

Considerations for improved performance of competition association assays analysed with the Motulsky-Mahan's "kinetics of competitive binding" model

scientific article published on 26 December 2019

Corrigendum to "A universal, homogenous assay for high throughput determination of binding kinetics" [Anal. Biochem. 468 (2015) 42-49].

scientific article published on 28 August 2016

Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors

scientific article published in 2022

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

scientific article

Electrostatic interactions of domain III stabilize the inactive conformation of mu-calpain.

scientific article published on September 2004

Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.

scientific article published on 30 March 2016

Halogen-Aromatic π Interactions Modulate Inhibitor Residence Times.

scientific article

Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.

scientific article published in July 2009

In vitro and in silico analysis of the effects of D receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

scientific article published on 21 September 2018

Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo

scientific article published on 14 November 2018

Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

scientific article published on 8 May 2002

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action.

scientific article published on 18 October 2017

Mu-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation

scientific article published on 01 May 2006

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor.

scientific article published on 27 May 2019

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.

scientific article published on 17 February 2016

Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors.

scientific article

Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain.

scientific article published on 18 February 2003

Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition. ⬇️

scientific article

Targeting BET bromodomains for cancer treatment

scientific article

Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

scientific article published on 27 April 2020

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