List of works - Laura Silvian

A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.

scientific article published on 5 August 2004

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

scientific article

Agonist‐Induced Transitions of the Acetylcholine Receptor ⬇️

scientific article published on September 1, 2003

Artemin crystal structure reveals insights into heparan sulfate binding

scientific article (publication date: 6 June 2006)

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus

scientific article

Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors

scientific article

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

scientific article

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery ⬇️

scientific article published on March 17, 2011

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

scientific article

Discovery of biaryls as RORγ inverse agonists by using structure-based design

scientific article

Distance between α‐Cys 192 of the Acetylcholine Receptor and Rhodamine‐labeled α‐Bungarotoxin Complexed to the Receptor ⬇️

scientific article published on May 13, 1998

Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor).

scientific article published on February 2006

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

scientific article

Inhibitors of protein-protein interactions: new methodologies to tackle this challenge

scientific article published on December 2013

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin

scientific article

New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors.

scientific article

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

scientific article

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

scientific article

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.

scientific article

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

scientific article

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

scientific article

Structure-based design of low-nanomolar PIM kinase inhibitors

scientific article

The anatomy of infidelity

scientific article published on 01 October 2001

List of works by Laura Silvian

A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Agonist‐Induced Transitions of the Acetylcholine Receptor ⬇️

Artemin crystal structure reveals insights into heparan sulfate binding

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus

Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery ⬇️

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Discovery of biaryls as RORγ inverse agonists by using structure-based design

Distance between α‐Cys 192 of the Acetylcholine Receptor and Rhodamine‐labeled α‐Bungarotoxin Complexed to the Receptor ⬇️

Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor).

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Inhibitors of protein-protein interactions: new methodologies to tackle this challenge

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin

New approaches for the treatment of pain: the GDNF family of neurotrophic growth factors.

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

Structure-based design of low-nanomolar PIM kinase inhibitors

The anatomy of infidelity