List of works - Annette Schürmann

3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.

scientific article

3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency

scientific article published on May 2014

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels

scientific article

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes

scientific article published on 01 September 2018

A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.

scientific article

ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues

scientific journal article

ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin.

scientific article published on 28 July 2008

Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

scientific article published on 28 December 2006

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

scientific article

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes

scientific article published on 22 November 2017

Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.

scientific article

An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes

scientific article

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing

scientific article published in February 2016

Biphasic alteration of glucose transport in 3T3-L1 cells during differentiation to the adipocyte-like phenotype.

scientific article

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice

scientific article published on 31 January 2015

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

scientific article published on 26 April 2002

Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes ⬇️

scientific article published on May 1, 1992

Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.

scientific article published on 26 May 2009

Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue.

scientific article

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

scientific article

Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases

scientific journal article

Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.

scientific article published on June 1994

Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominantly expressed in kidney

scientific journal article

Consuming fructose-sweetened beverages increases body adiposity in mice.

scientific article published in July 2005

Deletion of glucose transporter GLUT8 in mice increases locomotor activity

scientific article published on 7 May 2008

Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction

article

Diabetes prevalence in NZO females depends on estrogen action on liver fat content.

scientific article published on 20 October 2015

Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes

scientific article published on 08 September 2010

Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes

scientific article published on 22 July 2014

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.

scientific article

Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis.

scientific article published on 2 July 2011

Dynamic changes of muscle insulin sensitivity after metabolic surgery

scientific article published on 13 September 2019

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

scientific article published on 13 March 2020

Early zygotes are suitable recipients for bovine somatic nuclear transfer and result in cloned offspring.

scientific article

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.

scientific article published on 7 August 2014

Effects of obestatin on energy balance and growth hormone secretion in rodents

scientific article published on 28 September 2006

Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.

scientific article

Epigenetic contribution to obesity

scientific article published on 11 April 2020

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein

scientific article published on 13 October 2018

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

scientific article (publication date: 19 December 2016)

Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice

scientific article published on 24 March 2015

GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer

scientific article

GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern.

scientific article

GLUT8, the enigmatic intracellular hexose transporter.

scientific article published on 27 January 2009

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia ⬇️

scientific article published on April 4, 2011

Genetic and epigenetic control of metabolic health

scientific article

Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1 adipocytes.

scientific article published on December 2000

Glucose transport activity and ligand binding (cytochalasin B, IAPS-forskolin) of chimeric constructs of GLUT2 and GLUT4 expressed in COS-7-cells

scientific article published on 01 October 1996

Glucose transport activity and photolabelling with 3-[125I]iodo-4-azidophenethylamido-7-O-succinyldeacetyl (IAPS)-forskolin of two mutants at tryptophan-388 and -412 of the glucose transporter GLUT1: dissociation of the binding domains of forskolin

scientific article published on 01 March 1993

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.

scientific article published on 24 October 2016

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

scientific article published on 10 October 2016

Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly.

scientific article

High Variability of Insulin Sensitivity in Closely Related Obese Mouse Inbred Strains

scientific article published on 20 July 2016

High-fat, carbohydrate-free diet markedly aggravates obesity but prevents beta-cell loss and diabetes in the obese, diabetes-susceptible db/db strain

scientific article published on 2 December 2008

Identification and characterization of p49/STRAP as a novel GLUT4-binding protein

scientific article

Identification of four novel QTL linked to the metabolic syndrome in the Berlin Fat Mouse

scientific article published on 23 October 2021

Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

scientific article published on 24 November 2015

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

scientific article published on 03 May 2020

In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats

scientific article published on 01 February 1994

In-vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT3 in brain tissue from streptozotocin-diabetic rats

scientific article published on 01 October 1993

Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.

scientific article

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

scientific article published on 17 April 2003

Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7.

scientific article published on 6 May 2008

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

scientific article

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2)

scientific article

Localization of the binding domain of the inhibitory ligand forskolin in the glucose transporter GLUT-4 by photolabeling, proteolytic cleavage and a site-specific antiserum

scientific article published on 01 November 1992

Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction.

scientific article

Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle

scientific article published on 30 June 2021

Mouse ARF-related protein 1: genomic organization and analysis of its promoter

scientific article published on 01 March 2002

Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose

scientific journal article

Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands

scientific article published on 01 December 1995

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

scientific article published on 28 November 2011

Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice.

scientific article published on 9 September 2008

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

scientific article

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.

scientific article

Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice

scientific article

Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.

scientific article published on 27 February 2014

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome

scientific article published on 01 January 2012

Phosphorylation of the adipose/muscle-type glucose transporter (GLUT4) and its relationship to glucose transport activity ⬇️

scientific article published on July 1, 1992

Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle

scientific article

Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL

scientific article

Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition.

scientific article published on 6 July 2016

Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.

scientific article

Regulation of subcellular distribution of GLUT4 in cardiomyocytes: Rab4A reduces basal glucose transport and augments insulin responsiveness.

scientific article

Role of Conserved Arginine and Glutamate Residues on the Cytosolic Surface of Glucose Transporters for Transporter Function ⬇️

scientific article published on October 21, 1997

Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.

scientific article published on 11 October 2011

Serine-294 and threonine-295 in the exofacial loop domain between helices 7 and 8 of glucose transporters (GLUT) are involved in the conformational alterations during the transport process.

scientific article published on January 1998

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.

scientific article

Stimulation of fat accumulation in hepatocytes by PGE₂-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis

scientific article published on 10 September 2012

Subcellular distribution and activity of glucose transporter isoforms GLUT1 and GLUT4 transiently expressed in COS-7 cells ⬇️

scientific article published on July 15, 1992

Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa

scientific article

Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells

scientific article

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

scientific article

The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.

scientific article published on 14 April 2012

The complete classification of five-dimensional Dirichlet-Voronoi polyhedra of translational lattices.

scientific article published on 3 October 2016

The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.

scientific article

The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models

scientific article

The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function.

scientific article published in September 2004

The group-lending model and social closure: microcredit, exclusion, and health in Bangladesh

scientific article

The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell

scientific journal article

The myokine decorin is regulated by contraction and involved in muscle hypertrophy

scientific article

Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation

scientific article

Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations

article

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

scientific article (publication date: 2000)

List of works by Annette Schürmann

3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.

3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency

A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels

A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and Type 2 diabetes

A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance.

ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues

ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin.

Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity.

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration

Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes

Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.

An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes

Analysis of Genes Involved in Body Weight Regulation by Targeted Re-Sequencing

Biphasic alteration of glucose transport in 3T3-L1 cells during differentiation to the adipocyte-like phenotype.

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

Characterization of GTP-binding proteins in Golgi-associated membrane vesicles from rat adipocytes ⬇️

Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1.

Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue.

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases

Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.

Cloning of two splicing variants of the novel Ras-related GTPase Rab29 which is predominantly expressed in kidney

Consuming fructose-sweetened beverages increases body adiposity in mice.

Deletion of glucose transporter GLUT8 in mice increases locomotor activity

Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction

Diabetes prevalence in NZO females depends on estrogen action on liver fat content.

Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes

Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.

Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis.

Dynamic changes of muscle insulin sensitivity after metabolic surgery

EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake

Early zygotes are suitable recipients for bovine somatic nuclear transfer and result in cloned offspring.

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.

Effects of obestatin on energy balance and growth hormone secretion in rodents

Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.

Epigenetic contribution to obesity

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice

GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer

GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern.

GLUT8, the enigmatic intracellular hexose transporter.

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia ⬇️

Genetic and epigenetic control of metabolic health

Glucose deprivation induces Akt-dependent synthesis and incorporation of GLUT1, but not of GLUT4, into the plasma membrane of 3T3-L1 adipocytes.

Glucose transport activity and ligand binding (cytochalasin B, IAPS-forskolin) of chimeric constructs of GLUT2 and GLUT4 expressed in COS-7-cells

Glucose transport activity and photolabelling with 3-[125I]iodo-4-azidophenethylamido-7-O-succinyldeacetyl (IAPS)-forskolin of two mutants at tryptophan-388 and -412 of the glucose transporter GLUT1: dissociation of the binding domains of forskolin

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.

Hepatic DPP4 DNA Methylation Associates With Fatty Liver.

Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly.

High Variability of Insulin Sensitivity in Closely Related Obese Mouse Inbred Strains

High-fat, carbohydrate-free diet markedly aggravates obesity but prevents beta-cell loss and diabetes in the obese, diabetes-susceptible db/db strain

Identification and characterization of p49/STRAP as a novel GLUT4-binding protein

Identification of four novel QTL linked to the metabolic syndrome in the Berlin Fat Mouse

Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats

In-vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT3 in brain tissue from streptozotocin-diabetic rats

Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol.

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7.

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2)

Localization of the binding domain of the inhibitory ligand forskolin in the glucose transporter GLUT-4 by photolabeling, proteolytic cleavage and a site-specific antiserum

Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction.

Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle

Mouse ARF-related protein 1: genomic organization and analysis of its promoter

Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose

Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice.

Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.

Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice

Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle.

Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome

Phosphorylation of the adipose/muscle-type glucose transporter (GLUT4) and its relationship to glucose transport activity ⬇️