Search filters

List of works by Roel Ophoff

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

scientific article published on 22 March 2021

5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data

scientific article

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis

scientific article published in September 2017

A common variant in DRD3 receptor is associated with autism spectrum disorder

scientific article

A comprehensive family-based replication study of schizophrenia genes

scientific article

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder

scientific article

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

scientific article published on 17 July 2013

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

scientific article (publication date: 15 November 2014)

A large genome scan for rare CNVs in amyotrophic lateral sclerosis

scientific article

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

scientific article

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

scientific article

Aging effects on DNA methylation modules in human brain and blood tissue

scientific article

An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis

scientific article

Analysis of shared heritability in common disorders of the brain

scientific article published on 21 June 2018

Analysis ofFGGYas a risk factor for sporadic amyotrophic lateral sclerosis

article

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

scientific article published on December 2011

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

scientific article

Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain

scientific article

Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

scientific article published on 11 April 2012

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

scientific article published on 30 October 2019

At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia

scientific article published on 16 March 2011

Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia

scientific article

Characterization of genome-methylome interactions in 22 nuclear pedigrees

scientific article

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

preprint

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article

Common genetic variants influence human subcortical brain structures

scientific article

Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner ⬇️

scientific article published on September 6, 2012

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

scientific article published on 26 July 2011

Common variants conferring risk of schizophrenia

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

scientific article published on 30 October 2011

Complement genes contribute sex-biased vulnerability in diverse disorders

scientific article published on 11 May 2020

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

scientific article published on 24 February 2020

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

scientific article

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

scientific article published on 01 March 2020

Correction: Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy.

scientific article published on 25 August 2011

Correction: Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy.

scientific article

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium

article

Current status and future prospects for epigenetic psychopharmacology

scientific article

Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays

scientific article published on June 2008

Disruption of the neurexin 1 gene is associated with schizophrenia

scientific article

Efficient strategy for detecting gene × gene joint action and its application in schizophrenia

scientific article

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

scientific article published on 06 December 2019

Erratum: Corrigendum: Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

scholarly article published in Nature Genetics

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene

scientific article

Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder

scientific article published on 5 January 2012

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.

scientific article

Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background

scientific article

Gene networks associated with conditional fear in mice identified using a systems genetics approach

scientific article

Gene-network analysis identifies susceptibility genes related to glycobiology in autism

scientific article

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

scholarly article published 28 August 2017

Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects

scientific article

Genetic architecture of subcortical brain structures in 38,851 individuals

scientific article published on 21 October 2019

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

scientific article

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

scientific article published on 16 December 2007

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

scholarly article

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

scientific article published in October 2013

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

scientific article

Genome-wide association study identifies 30 loci associated with bipolar disorder.

scientific article

Genome-wide association study identifies 48 common genetic variants associated with handedness

scientific article published on 28 September 2020

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

scientific article

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

scientific article published in June 2021

Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

scientific article

Genomewide association study identifies 30 loci associated with bipolar disorder

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

article

Hippocampal gene expression analysis highlights Ly6a/Sca-1 as candidate gene for previously mapped novelty induced behaviors in mice

scientific article

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

scientific article published on 13 October 2016

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

scientific journal article

Identification of common variants associated with human hippocampal and intracranial volumes

scientific article published on 15 April 2012

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy

scientific article

Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood

scientific article

Increased paternal age and the influence on burden of genomic copy number variation in the general population

scientific article published on 13 January 2013

Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia

scientific article

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI

scientific article published on 13 May 2019

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis

scientific article (publication date: 2012)

Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia

scientific article

Is human blood a good surrogate for brain tissue in transcriptional studies? ⬇️

scientific article published on October 20, 2010

Large recurrent microdeletions associated with schizophrenia

scientific article

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.

scientific article

Markov Models for inferring copy number variations from genotype data on Illumina platforms

scientific article

Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness

scientific article

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Multiple common variants for celiac disease influencing immune gene expression

scientific article

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

scientific article

No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder

scientific article published on 8 June 2011

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

scientific article

No evidence that common genetic risk variation is shared between schizophrenia and autism

scientific article published on 28 November 2012

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

scientific article published in October 2013

Paternal age and psychiatric disorders: findings from a Dutch population registry

scientific article

Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis

scientific article published on 23 May 2016

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

scientific article published on 16 March 2018

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

scientific journal article

Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

scientific article

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

scientific article published on 22 November 2018

Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid

scientific article

Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples

scientific article

Sex-Dependent Novelty Response in Neurexin-1α Mutant Mice ⬇️

scientific article published on February 13, 2012

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

scientific article

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

scientific article published on 16 February 2020

Systematic genotype-phenotype analysis of autism susceptibility loci implicates additional symptoms to co-occur with autism

scientific article

TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease

scientific article

The Alkaline Phosphatase (ALPL) Locus Is Associated with B6 Vitamer Levels in CSF and Plasma

article

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

scientific article

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis.

scientific article

The genetic architecture of the human cerebral cortex

The genetic architecture of the human cerebral cortex

scientific article

The relationship of DNA methylation with age, gender and genotype in twins and healthy controls

scientific article

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

scientific article

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

scientific article

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

article

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression

scientific article

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

scientific article

Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients

scientific article

What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

scientific article published on 29 July 2020

Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect

Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

scientific article published in December 2017

Wnt signaling and Dupuytren's disease

scientific article

Paulina is supported by:

About Paulina

Help