List of works - Paola Vitale

A novel injectable formulation of 6-fluoro-l-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson's disease

scientific article published on 21 January 2017

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents.

scientific article published on 16 July 2016

Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts.

scientific article published on 23 November 2016

COX-1 Inhibitors: Beyond Structure Toward Therapy.

scientific article published on 25 April 2016

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

scientific article published on 25 January 2012

Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.

scientific article published on 30 September 2017

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

scientific article published on 28 February 2015

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

scientific article published on 9 June 2017

Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs)

scientific article published on 02 May 2016

Ligand-Free Bioinspired Suzuki-Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents

scientific article published on 05 September 2018

Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis

scientific article published on 18 August 2018

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

scientific article

Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

scientific article published on 05 August 2020

Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.

scientific article published on 2 January 2014

Selective COX-1 inhibition: A therapeutic target to be reconsidered.

scientific article published on January 2010

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

scientific article published on 09 January 2015

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

scientific article

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).

scientific article

Sustainable chemo-enzymatic preparation of enantiopure (<i>R</i>)-β-hydroxy-1,2,3-triazoles <i>via</i> lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents

scientific article published in 2020

Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors

scientific article published on 16 May 2013

The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

scientific article published in December 2009

Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability

scientific article published on 15 December 2018

Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium.

scientific article published on 11 July 2017

Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-Catalysed Cross-Coupling Reactions between Organolithium Reagents and (Hetero)aryl Halides

scientific article published on 17 January 2019

List of works by Paola Vitale

A novel injectable formulation of 6-fluoro-l-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson's disease

An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents.

Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts.

COX-1 Inhibitors: Beyond Structure Toward Therapy.

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier.

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation

Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs)

Ligand-Free Bioinspired Suzuki-Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents

Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.

Selective COX-1 inhibition: A therapeutic target to be reconsidered.

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).

Sustainable chemo-enzymatic preparation of enantiopure (<i>R</i>)-β-hydroxy-1,2,3-triazoles <i>via</i> lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents

Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors

The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability

Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium.

Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-Catalysed Cross-Coupling Reactions between Organolithium Reagents and (Hetero)aryl Halides