List of works - Alexandre Puissant

A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function

scientific article published on 24 July 2014

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death

scientific article

Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition.

scientific article published on 9 October 2006

Autophagy, a key mechanism of oncogenesis and resistance in leukemia

scientific article published on 12 December 2016

BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice

scientific article published on 25 July 2016

Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness

scientific article

Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.

scientific article published on 30 June 2009

Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.

scientific article

In vitro and in vivo anti-melanoma effects of ciglitazone.

scientific article

Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.

scientific article published on 2 April 2009

Mechanism of action of the multikinase inhibitor Foretinib.

scientific article published in December 2011

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

scientific article

Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.

scientific article published on 23 November 2010

SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.

scientific article published on 20 June 2011

SYK is a critical regulator of FLT3 in acute myeloid leukemia

scientific article

SYK regulates mTOR signaling in AML.

scientific article

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

scientific article published on 09 February 2022

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

scientific article published on 14 December 2012

Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae

scientific article published on 14 July 2011

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

scientific article published on 21 February 2013

Targeting autophagy to fight hematopoietic malignancies.

scientific article published on 15 September 2010

Targeting lysosomes to eradicate imatinib-resistant chronic myelogenous leukemia cells.

scientific article published on 8 April 2010

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

scientific article

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production ⬇️

scientific article published on May 4, 2012

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

scientific article published on 6 December 2011

The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression.

scientific article

Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties

scientific article

Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis.

scientific article published on 25 April 2012

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

scientific article published on 16 March 2020

List of works by Alexandre Puissant

A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death

Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition.

Autophagy, a key mechanism of oncogenesis and resistance in leukemia

BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice

Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness

Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.

Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness.

In vitro and in vivo anti-melanoma effects of ciglitazone.

Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.

Mechanism of action of the multikinase inhibitor Foretinib.

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.

SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.

SYK is a critical regulator of FLT3 in acute myeloid leukemia

SYK regulates mTOR signaling in AML.

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

Structure elucidation of the new citharoxazole from the Mediterranean deep-sea sponge Latrunculia (Biannulata) citharistae

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

Targeting autophagy to fight hematopoietic malignancies.

Targeting lysosomes to eradicate imatinib-resistant chronic myelogenous leukemia cells.

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death.

The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production ⬇️

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression.

Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties

Ultrasound-assisted one-pot synthesis of anti-CML nucleosides featuring 1,2,3-triazole nucleobase under iron-copper catalysis.

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer