List of works - Torkild Visnes

A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation

scientific article

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination

scientific article published on 21 October 2013

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

scientific article

Computational and Experimental Druggability Assessment of Human DNA Glycosylases

scientific article published on 05 July 2019

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

scientific article published on 15 January 2016

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I

scientific article

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

scientific article

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

scientific article published on 10 February 2021

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

scientific article

Targeting BER enzymes in cancer therapy

scientific article published on 25 August 2018

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

scientific article published on 19 November 2020

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions

scientific article

The rate of base excision repair of uracil is controlled by the initiating glycosylase

scientific article

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

scientific article published on 04 February 2020

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

scientific article

Uracil in DNA and its processing by different DNA glycosylases

scientific article

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

scientific article

Validation and development of MTH1 inhibitors for treatment of cancer.

scientific article

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

scientific article published on 5 December 2016

mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome

scientific article published on 23 February 2017

List of works by Torkild Visnes

A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

Computational and Experimental Druggability Assessment of Human DNA Glycosylases

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Targeting BER enzymes in cancer therapy

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions

The rate of base excision repair of uracil is controlled by the initiating glycosylase

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Uracil in DNA and its processing by different DNA glycosylases

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

Validation and development of MTH1 inhibitors for treatment of cancer.

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de Lange Syndrome