List of works - Beatrice Macchi

3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication

scientific article published on 7 September 2008

A novel, cell-free PCR-based assay for evaluating the inhibitory activity of antiretroviral compounds against HIV reverse transcriptase.

scientific article published on 16 September 2013

Antiretroviral Therapy in HTLV-1 Infection: An Updated Overview

scientific article published on 01 May 2020

Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

scientific article

Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy

article

Apoptotic Cell Signaling in Lymphocytes from HIV+ Patients during Successful Therapy

article

Appraisal of a Simple and Effective RT-qPCR Assay for Evaluating the Reverse Transcriptase Activity in Blood Samples from HIV-1 Patients

scientific article published on 13 December 2020

Approaches towards the synthesis of 7-halo-1,2-dihydroxyindolizidines (7-halolentiginosines) thwarting Grob fragmentation processes

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

scientific article published on 29 October 2015

CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis

scientific article published on December 2003

Changes in apoptosis after interruption of potent antiretroviral therapy in patients with maximal HIV-1-RNA suppression

article

Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB

scientific article published on 02 March 2015

Comparison of membrane-associated proteins of murine cytolytic and helper cloned T-cell lines: identification of a protein, p24, prominent in membrane fractions from cytolytic but not helper T-cells.

scientific article

Correlation between P19 presence and MHC class II expression in human fetal astroglial cells cocultured with HTLV-I donor cells

scientific article published on June 1, 1992

Development and evaluation of a simple and effective RT-qPCR inhibitory assay for detection of the efficacy of compounds towards HIV reverse transcriptase.

scientific article published on 30 September 2017

Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol

scientific article published on 22 July 2016

Dysregulated NF-κB pathway in peripheral mononuclear cells of Alzheimer's disease patients

scientific article

Effect of human T lymphotropic retrovirus-I exposure on cultured human glioma cell lines.

scientific article published in January 1991

Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro

scientific article

Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on human T-cell leukemia virus type 1 infection in vitro

scientific article

Effector caspase activation, in the absence of a conspicuous apoptosis induction, in mononuclear cells treated with azidothymidine

scientific article

Effects of nucleoside-based antiretroviral chemotherapy on human T cell leukaemia/lymphotropic virus type 1 (HTLV-1) infection in vitro

scientific article

Efficacy of 3'-azido 3'deoxythymidine (AZT) in preventing HTLV-1 transmission to human cord blood mononuclear cells.

scientific article

Enantiomerically pure phosphonated carbocyclic 2'-oxa-3'-azanucleosides: synthesis and biological evaluation.

scientific article

Ene Reaction of Nitrosocarbonyl Mesitylene with the Cinnamyl Alcohol: Metabolic Activity and Apoptosis of the Synthetized 6-Chloropurine N,O-Nucleoside Analogues

scientific article published on 10 July 2018

First Case of Transfusion-Associated AIDS in Italy: A Single Transfusion with a 51-month Latency Period

article

Focus on recently developed assays for detection of resistance/sensitivity to reverse transcriptase inhibitors

scientific article published on 29 September 2018

Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma.

scientific article

HIV genome in peripheral blood mononuclear cells of seronegative regular sexual partners of HIV-infected subjects

scientific article published on 01 August 1989

HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.

scientific article published on September 2016

In situ hybridization of human immunodeficiency virus (HTLV-III) in cryostat sections of lymph nodes of lymphadenopathy syndrome patients.

scientific article

In vitro susceptibility of different human T-cell subpopulations and resistance of large granular lymphocytes to HTLV-I infection.

scientific article published on July 1987

Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease

scientific article published in November 2004

Inflammation and programmed cell death in Alzheimer's disease: comparison of the central nervous system and peripheral blood.

scientific article published on 21 January 2014

Inhibition of NF-κB activation sensitizes U937 cells to 3'-azido-3'-deoxythymidine induced apoptosis

scientific article

Inhibition of cell-to-cell transmission of human T-cell lymphotropic virus type 1 in vitro by carbohydrate-binding agents

scientific article published on 27 May 2008

Inverse correlation between CD8+ lymphocyte apoptosis and CD4+ cell counts during potent antiretroviral therapy in HIV patients

scientific article published on 12 February 2004

Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas: novel suppressor mechanism.

scientific article published in May 1983

Modulation of apoptosis during HTLV-1-mediated immortalization process in vitro

scientific article

NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells.

scientific article published on 10 May 2019

Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents

scientific article

Programmed cell death and natural killer cells in multiple sclerosis: new potential therapeutic targets?

scientific article published on May 2016

Protective effect of interferon beta on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood.

scientific article published on July 1993

Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro

scientific article published on 21 October 2005

Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors.

scientific article published on 2 May 2019

Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α

scientific article published on 05 May 2017

Recovery of HIV-related retroviruses from Italian patients with AIDS or AIDS-related complex and from asymptomatic at-risk individuals.

scientific article published in January 1987

Reducing the global burden of HTLV-1 infection: An agenda for research and action

scientific article

Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system.

scientific article published on 29 August 2015

Spontaneous and anti-Fas-induced apoptosis in lymphocytes from HIV-infected patients undergoing highly active anti-retroviral therapy

article

Stereoselective synthesis and biological evaluations of novel 3'-deoxy-4'-azaribonucleosides as inhibitors of hepatitis C virus RNA replication

scientific article published on July 2009

Susceptibility of primary HTLV-1 isolates from patients with HTLV-1-associated myelopathy to reverse transcriptase inhibitors.

scientific article

Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides

scientific article published on 15 February 2006

Synthesis of phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides: novel inhibitors of reverse transcriptase

scientific article

Synthesis of potential HIV integrase inhibitors inspired by natural polyphenol structures

article

Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs

scientific article published on 10 April 2016

Testing anti-HIV activity of antiretroviral agents in vitro using flow cytometry analysis of CEM-GFP cells infected with transfection-derived HIV-1 NL4-3.

scientific article published on 31 October 2015

The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine

scientific article published on 5 January 2010

Thymosin alpha 1 and HIV-1: recent advances and future perspectives

scientific article published on 20 January 2017

Thymosin α 1 potentiates the release by CD8(+) cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro

scientific article published on 22 June 2015

Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents

scientific article published on 29 March 2012

Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors

scientific article

List of works by Beatrice Macchi

3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication

A novel, cell-free PCR-based assay for evaluating the inhibitory activity of antiretroviral compounds against HIV reverse transcriptase.

Antiretroviral Therapy in HTLV-1 Infection: An Updated Overview

Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy

Apoptotic Cell Signaling in Lymphocytes from HIV+ Patients during Successful Therapy

Appraisal of a Simple and Effective RT-qPCR Assay for Evaluating the Reverse Transcriptase Activity in Blood Samples from HIV-1 Patients

Approaches towards the synthesis of 7-halo-1,2-dihydroxyindolizidines (7-halolentiginosines) thwarting Grob fragmentation processes

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

CD4+ lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8+ cell apoptosis

Changes in apoptosis after interruption of potent antiretroviral therapy in patients with maximal HIV-1-RNA suppression

Characterization of the enhanced apoptotic response to azidothymidine by pharmacological inhibition of NF-kB

Comparison of membrane-associated proteins of murine cytolytic and helper cloned T-cell lines: identification of a protein, p24, prominent in membrane fractions from cytolytic but not helper T-cells.

Correlation between P19 presence and MHC class II expression in human fetal astroglial cells cocultured with HTLV-I donor cells

Development and evaluation of a simple and effective RT-qPCR inhibitory assay for detection of the efficacy of compounds towards HIV reverse transcriptase.

Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol

Dysregulated NF-κB pathway in peripheral mononuclear cells of Alzheimer's disease patients

Effect of human T lymphotropic retrovirus-I exposure on cultured human glioma cell lines.

Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro

Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on human T-cell leukemia virus type 1 infection in vitro

Effector caspase activation, in the absence of a conspicuous apoptosis induction, in mononuclear cells treated with azidothymidine

Effects of nucleoside-based antiretroviral chemotherapy on human T cell leukaemia/lymphotropic virus type 1 (HTLV-1) infection in vitro

Efficacy of 3'-azido 3'deoxythymidine (AZT) in preventing HTLV-1 transmission to human cord blood mononuclear cells.

Enantiomerically pure phosphonated carbocyclic 2'-oxa-3'-azanucleosides: synthesis and biological evaluation.

Ene Reaction of Nitrosocarbonyl Mesitylene with the Cinnamyl Alcohol: Metabolic Activity and Apoptosis of the Synthetized 6-Chloropurine N,O-Nucleoside Analogues

First Case of Transfusion-Associated AIDS in Italy: A Single Transfusion with a 51-month Latency Period

Focus on recently developed assays for detection of resistance/sensitivity to reverse transcriptase inhibitors

Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma.

HIV genome in peripheral blood mononuclear cells of seronegative regular sexual partners of HIV-infected subjects

HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.

In situ hybridization of human immunodeficiency virus (HTLV-III) in cryostat sections of lymph nodes of lymphadenopathy syndrome patients.

In vitro susceptibility of different human T-cell subpopulations and resistance of large granular lymphocytes to HTLV-I infection.

Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease

Inflammation and programmed cell death in Alzheimer's disease: comparison of the central nervous system and peripheral blood.

Inhibition of NF-κB activation sensitizes U937 cells to 3'-azido-3'-deoxythymidine induced apoptosis

Inhibition of cell-to-cell transmission of human T-cell lymphotropic virus type 1 in vitro by carbohydrate-binding agents

Inverse correlation between CD8+ lymphocyte apoptosis and CD4+ cell counts during potent antiretroviral therapy in HIV patients

Lymphoid cell-glioma cell interaction enhances cell coat production by human gliomas: novel suppressor mechanism.

Modulation of apoptosis during HTLV-1-mediated immortalization process in vitro

NF-κB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells.

Phosphonated carbocyclic 2'-oxa-3'-azanucleosides as new antiretroviral agents

Programmed cell death and natural killer cells in multiple sclerosis: new potential therapeutic targets?

Protective effect of interferon beta on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood.

Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro

Pyrimidine 2,4-Diones in the Design of New HIV RT Inhibitors.

Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α

Recovery of HIV-related retroviruses from Italian patients with AIDS or AIDS-related complex and from asymptomatic at-risk individuals.

Reducing the global burden of HTLV-1 infection: An agenda for research and action

Role of inflammation and apoptosis in multiple sclerosis: Comparative analysis between the periphery and the central nervous system.

Spontaneous and anti-Fas-induced apoptosis in lymphocytes from HIV-infected patients undergoing highly active anti-retroviral therapy

Stereoselective synthesis and biological evaluations of novel 3'-deoxy-4'-azaribonucleosides as inhibitors of hepatitis C virus RNA replication

Susceptibility of primary HTLV-1 isolates from patients with HTLV-1-associated myelopathy to reverse transcriptase inhibitors.

Synthesis and biological evaluation of phosphonated dihydroisoxazole nucleosides

Synthesis of phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides: novel inhibitors of reverse transcriptase

Synthesis of potential HIV integrase inhibitors inspired by natural polyphenol structures

Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs

Testing anti-HIV activity of antiretroviral agents in vitro using flow cytometry analysis of CEM-GFP cells infected with transfection-derived HIV-1 NL4-3.

The novel proapoptotic activity of nonnatural enantiomer of Lentiginosine

Thymosin alpha 1 and HIV-1: recent advances and future perspectives

Thymosin α 1 potentiates the release by CD8(+) cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro

Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents

Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors