List of works - Nobumoto Watanabe

A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.

scientific article published on October 1993

A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration

scientific article published on 04 January 2019

Boron-based inhibitors of acyl protein thioesterases 1 and 2.

scientific article

CD147-induced cell proliferation is associated with Smad4 signal inhibition

scientific article published on 3 July 2017

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

scientific article published on 01 June 1999

Chemical fragment arrays for rapid druggability assessment.

scientific article published on 18 February 2016

Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana

scientific article

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

scientific article

Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities

scientific article

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

scientific article

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

scientific article

Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

scientific article

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

scientific article published on January 1996

Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.

scientific article

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

scientific article

Effects of emetine on initiation of DNA synthesis in embryonic cells of sea urchin

scientific article published on 01 November 1983

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1

scientific article

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

scientific article published on 01 July 1997

Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.

scientific article published on 19 April 2006

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.

scientific article

Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2

scientific article published on 02 April 2008

Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells

scientific article

Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening.

scientific article

In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design.

scientific article published on 25 November 2014

Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells.

scientific article published on August 2000

Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity

scientific article

Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.

scientific article

Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae.

scientific article

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition

scientific article

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

scientific article published on February 1998

Parthenogenetic activation of oocytes in c-mos-deficient mice

scientific journal article

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

scientific article

Phosphorylation-Dependent Protein-Protein Interaction Modules As Potential Molecular Targets for Cancer Therapy ⬇️

scientific article published on December 1, 2012

Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.

scientific article published on 29 September 2008

Replication timing: histone genes replicate during early S phase in cleavage-stage embryos of sea urchin.

scientific article

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

scientific article

Small molecules that target phosphorylation dependent protein-protein interaction.

scientific article

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

scientific article published in Nature

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

scientific article published in Nature

The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis.

scientific article published on 12 May 2008

The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes ⬇️

scientific article published on July 1, 1992

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684

scientific article published on 18 January 2017

Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.

scientific article

List of works by Nobumoto Watanabe

A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.

A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration

Boron-based inhibitors of acyl protein thioesterases 1 and 2.

CD147-induced cell proliferation is associated with Smad4 signal inhibition

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

Chemical fragment arrays for rapid druggability assessment.

Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

Dependence of cyclin E-CDK2 kinase activity on cell anchorage.

Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.

Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I.

Effects of emetine on initiation of DNA synthesis in embryonic cells of sea urchin

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1

Evidence for a mammalian Nim1-like kinase pathway acting at the G0-1/S transition

Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.

Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2

Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells

Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening.

In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design.

Induction of M-phase arrest and apoptosis after HIV-1 Vpr expression through uncoupling of nuclear and centrosomal cycle in HeLa cells.

Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity

Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.

Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae.

PI 3-kinase-dependent phosphorylation of Plk1-Ser99 promotes association with 14-3-3γ and is required for metaphase-anaphase transition

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

Parthenogenetic activation of oocytes in c-mos-deficient mice

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.

Phosphorylation-Dependent Protein-Protein Interaction Modules As Potential Molecular Targets for Cancer Therapy ⬇️

Polo-like kinase 1 phosphorylates and regulates Bcl-x(L) during pironetin-induced apoptosis.

Replication timing: histone genes replicate during early S phase in cleavage-stage embryos of sea urchin.

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

Small molecules that target phosphorylation dependent protein-protein interaction.

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis.

The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes ⬇️

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684

Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.