List of works - Mingfeng Yu

A novel series of N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amines as highly potent CDK4/6 inhibitors.

scientific article

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

scientific article published on 9 September 2015

CDK5 in oncology: recent advances and future prospects.

scientific article published on 27 October 2017

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

scientific article

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

scientific article published on 21 December 2017

Discovery and Pharmacological Characterisation of a Novel Series of Highly Selective Inhibitors of Cyclin-Dependent Kinases 4 and 6 as Anticancer Agents.

scientific article published on 11 August 2017

Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities

scientific article published on 10 March 2014

Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.

scientific article published on 17 March 2015

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

scientific article published on 12 February 2014

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia.

scientific article published on 3 August 2017

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation.

scientific article published on 3 February 2017

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

scientific article published on 12 August 2015

In Search of Novel CDK8 Inhibitors by Virtual Screening

scientific article

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

scientific article

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells

scientific article published on 23 July 2016

MAP kinase-interacting kinases--emerging targets against cancer

scientific article

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

scientific article published on 18 August 2014

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

scientific article published on 4 June 2015

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

scientific article published on 16 December 2014

Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents.

scientific article published on 24 October 2016

Targeting CDK6 in cancer: State of the art and new insights

scientific article

Targeting CDK9 for treatment of colorectal cancer

scientific article published on 21 August 2019

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

scientific article

Targeting Pim kinases for cancer treatment: opportunities and challenges

scientific article

Unveiling new chemical scaffolds as Mnk inhibitors.

scientific article published on 24 February 2016

List of works by Mingfeng Yu

A novel series of N-(pyridin-2-yl)-4-(thiazol-5-yl)pyrimidin-2-amines as highly potent CDK4/6 inhibitors.

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

CDK5 in oncology: recent advances and future prospects.

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Discovery and Pharmacological Characterisation of a Novel Series of Highly Selective Inhibitors of Cyclin-Dependent Kinases 4 and 6 as Anticancer Agents.

Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities

Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation.

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia.

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation.

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

In Search of Novel CDK8 Inhibitors by Virtual Screening

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells

MAP kinase-interacting kinases--emerging targets against cancer

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents.

Targeting CDK6 in cancer: State of the art and new insights

Targeting CDK9 for treatment of colorectal cancer

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

Targeting Pim kinases for cancer treatment: opportunities and challenges

Unveiling new chemical scaffolds as Mnk inhibitors.