List of works by Philippe Valet

A biomimetic hydrogel functionalized with adipose ECM components as a microenvironment for the 3D culture of human and murine adipocytes.

scientific article published on 11 April 2017

A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification.

scientific article

Absence of arterial hypertension despite chronic plasma noradrenaline elevation: evidence for down-regulation of alpha-adrenoceptors. A case report

scientific article published on 01 January 1991

Acute release of catecholamines on circulating blood cell adrenoceptors and metabolic indices in dog

scientific article published on 01 January 1988

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer.

scientific article

Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP)

scientific article published on 17 January 2019

Adipokine expression profile in adipocytes of different mouse models of obesity.

scientific article published in December 2005

Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer.

scientific article published on 27 May 2012

Adrenergic supersensitivity in parkinsonians with orthostatic hypotension

scientific article published on 01 December 1990

Adrenoceptors in the diagnosis of phaeochromocytoma

scientific article published on 01 August 1987

Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.

scientific article published on December 1994

Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment

scientific article published on 09 January 2007

Altered food consumption in mice lacking lysophosphatidic acid receptor-1.

scientific article published in December 2009

Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue.

scientific article

Amine oxidase substrates for impaired glucose tolerance correction.

scientific article

Androgenic regulation of adipocyte alpha 2-adrenoceptor expression in male and female Syrian hamsters: proposed transcriptional mechanism ⬇️

scientific article published on January 1, 1992

Antilipolytic effects of alpha 2-adrenergic agonists, neuropeptide Y, adenosine, and PGE1 in mammal adipocytes.

scientific article

Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.

scientific article

Apelin affects the mouse aging urinary peptidome with minimal effects on kidney

scientific article published on 23 July 2019

Apelin and energy metabolism.

scientific article

Apelin is a novel islet peptide.

scientific article published on 24 March 2010

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction

scientific article published on 15 June 2017

Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.

scientific article published on 25 October 2011

Apelin receptors: From signaling to antidiabetic strategy.

scientific article published on 22 May 2015

Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity.

scientific article

Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.

scientific article published on 14 August 2013

Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo ⬇️

scientific article published on January 19, 2011

Apelin stimulates glucose utilization in normal and obese insulin-resistant mice

scientific article

Apelin targets gut contraction to control glucose metabolism via the brain

scientific article

Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.

scientific article

Apelin, a promising target for type 2 diabetes treatment?

scientific article published on 22 March 2012

Apelin, diabetes, and obesity.

scientific article published on August 2011

Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity.

scientific article published on 23 March 2016

Apelin: an antithrombotic factor that inhibits platelet function.

scientific article published on 3 December 2015

Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter

scientific article published on 01 May 2012

Benzylamine exhibits insulin-like effects on glucose disposal, glucose transport, and fat cell lipolysis in rabbits and diabetic mice.

scientific article published on 20 February 2004

Beta-1 adrenergic inhibition of kallikrein release from rat kidney cortical slices

scientific article published on 01 May 1990

Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure.

scientific article published on 12 June 2008

Ca(2+)-independent phospholipase A2 is required for alpha2-adrenergic-induced preadipocyte spreading.

scientific article published on November 1999

Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.

scientific article published on 24 September 2014

Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload

scientific article published on 01 January 1994

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

scientific article published on 01 December 2019

Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis

scientific article

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

scientific article published on 25 May 2011

Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

scientific article

Changes in beta-adrenergic receptivity during human left ventricular hypertrophy due to pressure overload

scientific article published on 01 December 1993

Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa

scientific article

Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism.

scientific article published in February 2018

Circadian Feeding Drive of Metabolic Activity in Adipose Tissue and not Hyperphagia Triggers Overweight in Mice: Is There a Role of the Pentose-Phosphate Pathway?

scientific article published on 06 December 2011

Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model.

scientific article published on 21 January 2017

Corrigendum: Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch

scientific article published on 31 May 2016

Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression.

scientific article published on March 2003

Decreased Resistin Expression in Mice with Different Sensitivities to a High-Fat Diet

scientific article published on 01 November 2001

Depot-specific regulation of autotaxin with obesity in human adipose tissue

scientific article published on 27 May 2012

Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment

scientific article published on 19 September 2018

Differential regulation of fat cell beta-2 and beta-1 adrenoceptors by endogenous catecholamines in dog

scientific article published on 01 April 1989

Distribution of PYY receptors in human fat cells: an antilipolytic system alongside the alpha 2-adrenergic system

scientific article published on 01 July 1993

Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

scientific article published on 07 April 2008

Effect of non-digestible gluco-oligosaccharides on glucose sensitivity in high fat diet fed mice.

scientific article published in September 2003

Effects of dietary eicosapentaenoic acid (EPA) supplementation in high-fat fed mice on lipid metabolism and apelin/APJ system in skeletal muscle.

scientific article

Effects of histamine on triglyceride breakdown in mouse adipocytes

scientific article published on 01 April 2007

Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats.

scientific article published in June 2005

Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway.

scientific article published on 20 April 2018

Expanding role for the apelin/APJ system in physiopathology.

scientific article published on December 2007

Experimental and clinical approaches to treatment of hypertension by dopamine receptor agonists.

scientific article published on January 1987

Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.

scientific article published in August 2012

Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes.

scientific article published on June 1997

Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons

scientific article published on 31 January 2018

Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide.

scientific article

Human adipocytes express alpha 2-adrenergic receptor of the alpha 2A-subtype only: pharmacological and genetic evidence.

scientific article published on January 1995

Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements.

scientific article published in October 2002

Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.

scientific article published on 18 September 2013

Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.

scientific article published on 18 December 2014

Identification and functional studies of a specific peptide YY-preferring receptor in dog adipocytes

scientific article published on 01 October 1992

Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake

scientific article

Impairment of adipose tissue in Prader-Willi syndrome rescued by growth hormone treatment

scientific article published on 10 January 2014

Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A.

scientific article published on 10 February 2017

In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue.

scientific article published in December 2001

In vivo upregulation of adipocyte alpha 2-adrenoceptors by androgens is consequence of direct action on fat cells

scientific article published on 01 October 1994

Increased monoamine oxidase and semicarbazide-sensitive amine oxidase activities in white adipose tissue of obese dogs fed a high-fat diet

scientific article published on 01 June 2006

Influence of high-fat diet on amine oxidase activity in white adipose tissue of mice prone or resistant to diet-induced obesity.

scientific article published in June 2005

Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.

scientific article

Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice.

scientific article published on 22 November 2006

Is Crohn's creeping fat an adipose tissue?

scientific article

Is adrenal medulla involved in the antihypertensive effect of nicardipine?

scientific article published on 01 March 1988

Isoprostanes as markers for muscle aging in older athletes.

scientific article

Jejunum Inflammation in Obese and Diabetic Mice Impairs Enteric Glucose Detection and Modifies Nitric Oxide Release in the Hypothalamus

scientific article published on 29 September 2010

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity

scientific article

LPA as a paracrine mediator of adipocyte growth and function.

scientific article

LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue.

scientific article

Levodopa up-regulates platelet alpha 2-adrenoceptors

scientific article published on 01 July 1990

Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice.

scientific article published on 10 January 2007

Lipomobilizing effects of procaterol and yohimbine in the conscious dog: comparison of endocrinological, metabolic and cardiovascular effects

scientific article published on May 1989

Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway.

scientific article

Lysophosphatidic acid and renal fibrosis.

scientific article published on 11 April 2008

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice.

scientific article published on 19 March 2013

Lysophosphatidic acid synthesis and release

scientific journal article

Lysophosphatidic acid-1-receptor targeting agents for fibrosis.

scientific article published on 24 March 2011

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

scientific article published on 23 February 2017

Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat

scientific article published on 15 March 2012

Matrix metalloproteinase 11 protects from diabesity and promotes metabolic switch

scientific article published on 29 April 2016

Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism

scientific article published on 04 July 2013

Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism.

scientific article published on 30 August 2005

Mildly oxidized LDL evokes a sustained Ca(2+)-dependent retraction of vascular smooth muscle cells

scientific article published on 01 October 1996

Modifications of mesenteric adipose tissue during moderate experimental colitis in mice.

scientific article

Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes

scientific article published on 01 June 1995

Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity during sinoaortic denervation in dogs.

scientific article published in February 1992

Native fructose extracted from apple improves glucose tolerance in mice.

scientific article published in December 2009

Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms

scientific article published on 12 February 2019

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth

scientific article published on 01 July 2018

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

scientific article published on 27 February 2012

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

scientific article published on 25 March 2022

Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of Fatty liver inflammation in obese mice.

scientific article

Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress

scientific article published on 03 January 2019

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

scientific article published on 12 January 2016

Pharmacological targeting of apelin impairs glioblastoma growth.

scientific article

Plasma catecholamines and adrenoceptors after chronic sinoaortic denervation in dogs

scientific article published on 01 January 1989

Platelet alpha 2- and leucocyte beta 2-adrenoceptors in phaeochromocytoma: effect of tumour removal

scientific article published on 01 October 1988

Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis

scientific article

Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.

scientific article

Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats.

scientific article published on May 2007

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

scientific article

Recent advances in the pharmacology of rilmenidine.

scientific article

Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway

scientific article published on 31 July 2015

Regulation of fat-cell function by alpha 2-adrenergic receptors.

scientific article published on January 1998

Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia.

scientific article published on November 2006

Relationship between arterial blood pressure disturbances and alpha adrenoceptor density

scientific article published on 01 May 1994

Rilmenidine (S 3341) and the sympathoadrenal system: adrenoreceptors, plasma and adrenal catecholamines in dogs

scientific article published on 01 December 1988

SHP2 sails from physiology to pathology.

scientific article published on 02 September 2015

Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice

scientific article published on 04 April 2007

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposition.

scientific article published on 13 February 2009

Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples

scientific article

Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury

scientific article published on 23 April 2015

TNFalpha up-regulates apelin expression in human and mouse adipose tissue.

scientific article published on 24 May 2006

The APJ receptor: a new therapeutic approach in diabetic treatment

scientific article

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

scientific article published on July 2015

The apelin/APJ system as a therapeutic target in metabolic diseases

scientific article published on 10 January 2019

The exerkine apelin reverses age-associated sarcopenia

scientific article published on 30 July 2018

The imidazoline I2-site ligands BU 224 and 2-BFI inhibit MAO-A and MAO-B activities, hydrogen peroxide production, and lipolysis in rodent and human adipocytes.

scientific article published on 23 September 2006

The intestinal glucose-apelin cycle controls carbohydrate absorption in mice

scientific article published on 10 January 2013

The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation

scientific article

The use of urinary proteomics in the assessment of suitability of mouse models for ageing

scientific article

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

scientific article

Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.

scientific article published on 16 November 2017

Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin

scientific article

Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia

scientific article published on 28 March 2016

Urinary kallikrein excretion in neurogenic hypertension in the dogs: possible relationship between kallikrein excretion and catecholamines

scientific article published on 01 January 1989

Vasoactive intestinal peptide and forskolin regulate proliferation of the HT29 human colon adenocarcinoma cell line

scientific article published on March 1, 1992

Verapamil interacts in vitro with alpha 2-adrenoceptors but does not modify alpha 2-receptivity in vivo

scientific article published on 01 September 1989

[Adipose tissue and cancer: a high risk tandem]

scientific article published on 01 April 2014

[Alpha 2-adrenergic receptors and arterial pressure]

scientific article published on 01 July 1989

[Beta adrenergic receptors and experimental left ventricular hypertrophy]

scientific article published on 01 August 1992

[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]

scientific article published on 01 August 1993

[Changes in myocardial beta adrenergic receptors in left ventricular hypertrophy caused by barometric and volumetric overloads]

scientific article published on 01 August 1994

[Development of nutritional obesity in transgenic mice with an adrenergic receptivity in adipose tissue comparable with that of humans]

scientific article published on 01 February 2002

[Dissemination of prostate cancer: a way paved of fat].

scientific article published in June 2016

[Metabolic and trophic role of catecholamines in the development of white adipose tissue]

scientific article published on 01 September 1999

[Myocardial beta-adrenergic receptors and left ventricular hypertrophy induced by pressure overload in man]

scientific article published on 01 August 1992

[Value of the study of circulating adrenergic receptors in the diagnosis and surveillance after surgery of pheochromocytoma]

scientific article published on 01 June 1988

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