List of works by Karena Last

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

scientific article published on 14 December 2015

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5 ⬇️

scientific article published on 29 January 2019

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

scientific article

Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.

scientific article published in December 2012

Antibodies to MMP-cleaved aggrecan

scientific article published on 01 January 2001

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.

scientific article

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.

scientific article

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

scientific article published on 01 February 1996

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

scientific article

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.

scientific article published on 3 March 2011

Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan

scientific article published on 12 November 2008

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

scientific article

Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain

scientific article

N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.

scientific article published on 22 April 2005

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

scientific article published on 01 January 2010

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

scientific article published on September 2005

Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase

scientific article published on 01 November 1999

Recombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes

scientific article published in January 1991

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