List of works - Eric Batchelor

A synthetic-natural hybrid oscillator in human cells

scientific article

Abstract 3116: Dysregulated cholesterol synthesis is a therapeutic vulnerability in glioblastoma

scientific article published in 2017

Abstract B097: Dysregulated mevalonate and cholesterol synthesis is a therapeutic vulnerability in glioblastoma

scientific article published in 2018

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

scientific article

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.

scientific article published on 25 September 2017

Continuous control in bacterial regulatory circuits

scientific article

Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis

scientific article published on 10 March 2017

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.

scientific article published on 19 January 2017

Dissecting transcriptional amplification by MYC

scientific article published on 27 July 2020

FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells

scientific article published on 01 October 2020

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

scientific article published on 13 January 2016

Flexible CRISPR library construction using parallel oligonucleotide retrieval.

scientific article

Fourier analysis and systems identification of the p53 feedback loop

scientific article

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

scientific article published on 30 August 2017

Imaging OmpR localization in Escherichia coli

scientific article published in March 2006

METB-03. DISABLED CELL DENSITY SENSING BY TUMOR SUPPRESSORS LEADS TO DYSREGULATED CHOLESTEROL SYNTHESIS IN GLIOBLASTOMA

scientific article published in 2016

Modeling cell heterogeneity: from single-cell variations to mixed cells

scientific article published on 01 January 2013

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

scientific article published on 28 July 2017

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.

scientific article

Promoter decoding of transcription factor dynamics.

scientific article published on 5 November 2013

Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing

scientific article published on 11 February 2019

Recent progress and open challenges in modeling p53 dynamics in single cells.

scientific article published on 25 March 2017

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

scientific article

Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.

scholarly article

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards.

scientific article published on 25 February 2017

Stimulus-dependent dynamics of p53 in single cells

scientific article

Suppressing variation in synthetic circuits

scientific article

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.

scientific article

The ups and downs of p53: understanding protein dynamics in single cells

scientific article

Tuning of mRNA stability through altering 3'-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations

Using computational modeling and experimental synthetic perturbations to probe biological circuits

scientific article published in January 2015

p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.

scientific article published on 7 April 2016

p53 dynamics control cell fate

scientific article

p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions

scientific article published on 01 September 2019

List of works by Eric Batchelor

A synthetic-natural hybrid oscillator in human cells

Abstract 3116: Dysregulated cholesterol synthesis is a therapeutic vulnerability in glioblastoma

Abstract B097: Dysregulated mevalonate and cholesterol synthesis is a therapeutic vulnerability in glioblastoma

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.

CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level.

Continuous control in bacterial regulatory circuits

Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis

Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma.

Dissecting transcriptional amplification by MYC

FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

Flexible CRISPR library construction using parallel oligonucleotide retrieval.

Fourier analysis and systems identification of the p53 feedback loop

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

Imaging OmpR localization in Escherichia coli

METB-03. DISABLED CELL DENSITY SENSING BY TUMOR SUPPRESSORS LEADS TO DYSREGULATED CHOLESTEROL SYNTHESIS IN GLIOBLASTOMA

Modeling cell heterogeneity: from single-cell variations to mixed cells

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

NFκB Promotes Ovarian Tumorigenesis via Classical Pathways That Support Proliferative Cancer Cells and Alternative Pathways That Support ALDH+ Cancer Stem-like Cells.

Promoter decoding of transcription factor dynamics.

Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing

Recent progress and open challenges in modeling p53 dynamics in single cells.

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system.

Single-cell Gene Expression Profiling Using FACS and qPCR with Internal Standards.

Stimulus-dependent dynamics of p53 in single cells

Suppressing variation in synthetic circuits

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.

The ups and downs of p53: understanding protein dynamics in single cells

Tuning of mRNA stability through altering 3'-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations

Using computational modeling and experimental synthetic perturbations to probe biological circuits

p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.

p53 dynamics control cell fate

p53 pulse modulation differentially regulates target gene promoters to regulate cell fate decisions