List of works - Atsu Aiba

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury

scientific article

A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle

scientific article published on 3 February 2014

A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis

scientific article

A gene-targeted mouse model for chorea-acanthocytosis

scientific journal article

A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes

scientific article

Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.

scientific article published on 18 April 2018

Cdc42 is critical for cartilage development during endochondral ossification

scientific article published in January 2015

Cdc42 is crucial for facial and palatal formation during craniofacial development.

scientific article published on 8 January 2016

Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development

scientific article published on 25 February 2012

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

scientific article published on 05 February 2020

Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse

scientific article

Conditional mutant mice using tetracycline-controlled gene expression system in the brain.

scientific article published on 20 January 2007

Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury

scientific article published on 11 October 2016

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1

scientific journal article

Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice

scientific article

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.

scientific article published on 21 September 2016

Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.

scientific article published on 16 December 2009

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

scientific journal article

Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect

scientific journal article

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

scientific article

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

scientific article published on 03 September 2019

Efficient marmoset genome engineering by autologous embryo transfer and CRISPR/Cas9 technology

scientific article published on 12 October 2021

Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.

scientific article

Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses.

scientific article

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

scientific article published on August 2008

Farnesylation of retinal transducin underlies its translocation during light adaptation

scientific article

Functional analysis of molecules involved in synaptic plasticity in the cerebellum

scientific article published on March 1, 2008

Generation of L7-tTA knock-in mice.

scientific article published on 31 March 2009

Generation of RGS8 null mutant mice by Cre/loxP system.

scientific article

Generation of cloned mice from adult neurons by direct nuclear transfer.

scientific article published on 4 February 2015

Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase

scientific article published on 27 April 2018

Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells.

scientific article published in March 2011

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

scientific article published on 26 February 2019

Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1.

scientific article

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice

scientific article published on 20 July 2020

Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

scientific article published in December 1995

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

scientific article

K-ras is essential for the development of the mouse embryo

scientific article published on 01 September 1997

Localization of phospholipase Cbeta isozymes in the mouse cerebellum

scientific article published on 01 November 1999

Loss of adaptability of horizontal optokinetic response eye movements in mGluR1 knockout mice.

scientific article published in February 2002

Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior

scientific article published on 12 March 2022

Mouse liaison for integrative brain research

scientific article published on 23 February 2007

Novel role of Rac-Mid1 signaling in medial cerebellar development.

scientific article published in May 2017

Odor-induced persistent discharge of mitral cells in the mouse olfactory bulb.

scientific article

Oocyte-Activating Capacity of Fresh and Frozen-Thawed Spermatids in the Common Marmoset (Callithrix jacchus).

scientific article published on 19 February 2018

Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes

scientific article published on 24 July 2019

Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.

scientific article published in July 2008

Rac1 is required for the formation of three germ layers during gastrulation.

scientific article published in December 1998

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.

scientific article published on 2 November 2015

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

scientific article published in October 1994

Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation

scientific article published on 01 April 2000

Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation

scientific article published on 05 March 2009

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

scientific article published on 15 May 2014

Rho GTPase protein Cdc42 is critical for postnatal cartilage development.

scientific article published on 25 January 2016

Role for RalA downstream of Rac1 in skeletal muscle insulin signalling.

scientific article

Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons.

scientific article

Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle

scientific article

Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development.

scientific article published in December 2001

Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.

scientific article published on 22 May 2014

Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface.

scientific article

Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain

scientific journal article

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus.

scientific article published on July 2004

Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a.

scientific article published in August 2011

Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.

scientific article published in July 2005

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

scientific journal article

Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage.

scientific article published on 19 January 2018

Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

scientific article published on 8 February 2016

The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes

scientific article

The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus.

scientific article published on 18 August 2016

The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse

scientific article published on 24 June 2018

The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain

scientific article published on 8 August 2014

The simultaneous induction of tumorigenesis and Cre-loxP recombination in mice

scientific article published on 31 March 2009

The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.

scientific article published in February 2014

Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).

scientific article published on 16 February 2017

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

scientific article published in Scientific Reports

mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory

scientific article published on 14 May 2019

mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning.

scientific article

List of works by Atsu Aiba

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury

A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle

A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis

A gene-targeted mouse model for chorea-acanthocytosis

A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes

Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.

Cdc42 is critical for cartilage development during endochondral ossification

Cdc42 is crucial for facial and palatal formation during craniofacial development.

Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development

Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus

Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse

Conditional mutant mice using tetracycline-controlled gene expression system in the brain.

Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1

Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.

Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary

Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Efficient marmoset genome engineering by autologous embryo transfer and CRISPR/Cas9 technology

Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.

Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses.

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

Farnesylation of retinal transducin underlies its translocation during light adaptation

Functional analysis of molecules involved in synaptic plasticity in the cerebellum

Generation of L7-tTA knock-in mice.

Generation of RGS8 null mutant mice by Cre/loxP system.

Generation of cloned mice from adult neurons by direct nuclear transfer.

Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase

Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells.

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1.

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice

Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

K-ras is essential for the development of the mouse embryo

Localization of phospholipase Cbeta isozymes in the mouse cerebellum

Loss of adaptability of horizontal optokinetic response eye movements in mGluR1 knockout mice.

Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior

Mouse liaison for integrative brain research

Novel role of Rac-Mid1 signaling in medial cerebellar development.

Odor-induced persistent discharge of mitral cells in the mouse olfactory bulb.

Oocyte-Activating Capacity of Fresh and Frozen-Thawed Spermatids in the Common Marmoset (Callithrix jacchus).

Rac-Dependent Signaling from Keratinocytes Promotes Differentiation of Intradermal White Adipocytes

Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.

Rac1 is required for the formation of three germ layers during gastrulation.

Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation

Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

Rho GTPase protein Cdc42 is critical for postnatal cartilage development.

Role for RalA downstream of Rac1 in skeletal muscle insulin signalling.

Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons.

Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle

Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development.

Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.

Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface.

Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus.

Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with Homer1a.

Synaptically driven endocannabinoid release requires Ca2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase Cbeta4 signaling cascade in the cerebellum.

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage.

Territories of heterologous inputs onto Purkinje cell dendrites are segregated by mGluR1-dependent parallel fiber synapse elimination

The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes

The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus.

The anatomical pathway from the mesodiencephalic junction to the inferior olive relays perioral sensory signals to the cerebellum in the mouse

The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain

The simultaneous induction of tumorigenesis and Cre-loxP recombination in mice

The synaptic targeting of mGluR1 by its carboxyl-terminal domain is crucial for cerebellar function.

Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors

mGluR1 in cerebellar Purkinje cells is essential for the formation but not expression of associative eyeblink memory

mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning.