List of works - Shinji Takada

A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk).

scientific article

Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators

scientific article published on 10 March 2008

Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite

scientific journal article

Analysis of the expression of two phosphoglycerate kinase genes in a mouse cultured cell line during activation and inactivation of the c-myc gene

scientific article published on 01 April 1989

Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling

scientific journal article

Assembly of protein complexes restricts diffusion of Wnt3a proteins

scientific article published on 10 October 2018

Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate

scientific article

Characterization of trans-acting factor(s) regulating beta-globin gene expression by in vivo competition.

scientific article published in July 1987

Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.

scientific article published on November 2000

Development and fibronectin signaling requirements of the zebrafish interrenal vessel

scientific article

Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.

scientific article

Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal.

scientific article

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

scientific journal article

Fgf18 is required for embryonic lung alveolar development

scientific journal article

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development.

scientific article published on 20 June 2013

Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish

scientific article published on 04 June 2018

Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.

scientific article published in June 2005

Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse

scientific journal article

Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites

scientific journal article

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

scientific article

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3

scientific journal article

Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.

scientific article published in April 2005

Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling

scientific article published on 01 October 2004

Leucophores are similar to xanthophores in their specification and differentiation processes in medaka

scientific article

Loss of mRor1 Enhances the Heart and Skeletal Abnormalities in mRor2-Deficient Mice: Redundant and Pleiotropic Functions of mRor1 and mRor2 Receptor Tyrosine Kinases ⬇️

scientific article published on December 1, 2001

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

scientific article

Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites.

scientific article published on 6 August 2012

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

scientific article published on May 28, 2013

Molecular mechanism for cyclic generation of somites: Lessons from mice and zebrafish.

scientific article published on 17 December 2015

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

scientific article

Motor neurons with axial muscle projections specified by Wnt4/5 signaling.

scientific article published on March 2009

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation

scientific article published on 01 January 2000

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite ⬇️

scientific article published on May 15, 1998

Nontrivial Effect of the Color-Exchange of a Donor/Acceptor Pair in the Engineering of Förster Resonance Energy Transfer (FRET)-Based Indicators

scientific article published on 27 May 2016

Notch signaling regulates venous arterialization during zebrafish fin regeneration.

scientific article published on 25 March 2015

PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation

scientific article published on 26 November 2020

Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation

scientific article

Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation.

scientific article published on 18 June 2015

Planar polarization of node cells determines the rotational axis of node cilia.

scientific article

Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR.

scientific article published on 17 November 2015

Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.

scientific article

Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.

scientific article published on 6 July 2016

R26-WntVis reporter mice showing graded response to Wnt signal levels

scientific article

Regulation of mammalian tooth cusp patterning by ectodin

scientific journal article

Reiterative expression of pax1 directs pharyngeal pouch segmentation in medaka

scientific article published on 31 March 2016

Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches

scientific article published on 22 February 2018

Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice ⬇️

scientific article published on January 1, 2011

Role of c-Myc on erythroid differentiation

scientific article published on October 1, 1992

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.

scientific article published on 7 December 2017

Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization

scientific article

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

scientific article published on 07 February 2017

Selective suppression of endogenous beta-globin gene expression by transferred beta-globin/TK chimeric gene in murine erythroleukemia cells

scientific article published on 01 June 1989

Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

scientific article published on 13 October 2008

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

scientific article

Tbx protein level critical for clock-mediated somite positioning is regulated through interaction between Tbx and Ripply

scientific article

The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation

scientific journal article

Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation

scientific article published on 19 September 2019

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA

scientific article

Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression

scientific article published on 5 December 2007

Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord

scientific article published on 16 January 2019

Wnt proteins promote neuronal differentiation in neural stem cell culture.

scientific article published in January 2004

Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.

scientific article published in June 2005

Wnt signalling required for expansion of neural crest and CNS progenitors.

scientific article published in October 1997

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression

scientific article published on 01 May 2001

Wnt-3a regulates somite and tailbud formation in the mouse embryo

scientific journal article

Wnt10a is involved in AER formation during chick limb development.

scientific article published in June 2005

Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.

scientific article

List of works by Shinji Takada

A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk).

Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators

Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite

Analysis of the expression of two phosphoglycerate kinase genes in a mouse cultured cell line during activation and inactivation of the c-myc gene

Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling

Assembly of protein complexes restricts diffusion of Wnt3a proteins

Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate

Characterization of trans-acting factor(s) regulating beta-globin gene expression by in vivo competition.

Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 beta-dependent phosphorylation of beta-catenin and down-regulates beta-catenin.

Development and fibronectin signaling requirements of the zebrafish interrenal vessel

Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development.

Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal.

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

Fgf18 is required for embryonic lung alveolar development

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development.

Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish

Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.

Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse

Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3

Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos.

Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling

Leucophores are similar to xanthophores in their specification and differentiation processes in medaka

Loss of mRor1 Enhances the Heart and Skeletal Abnormalities in mRor2-Deficient Mice: Redundant and Pleiotropic Functions of mRor1 and mRor2 Receptor Tyrosine Kinases ⬇️

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites.

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo ⬇️

Molecular mechanism for cyclic generation of somites: Lessons from mice and zebrafish.

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

Motor neurons with axial muscle projections specified by Wnt4/5 signaling.

Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite ⬇️

Nontrivial Effect of the Color-Exchange of a Donor/Acceptor Pair in the Engineering of Förster Resonance Energy Transfer (FRET)-Based Indicators

Notch signaling regulates venous arterialization during zebrafish fin regeneration.

PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation

Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation

Pharyngeal arch deficiencies affect taste bud development in the circumvallate papilla with aberrant glossopharyngeal nerve formation.

Planar polarization of node cells determines the rotational axis of node cilia.

Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR.

Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.

Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish.

R26-WntVis reporter mice showing graded response to Wnt signal levels

Regulation of mammalian tooth cusp patterning by ectodin

Reiterative expression of pax1 directs pharyngeal pouch segmentation in medaka

Ripply3 is required for the maintenance of epithelial sheets in the morphogenesis of pharyngeal pouches

Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice ⬇️

Role of c-Myc on erythroid differentiation

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus.

Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization

SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

Selective suppression of endogenous beta-globin gene expression by transferred beta-globin/TK chimeric gene in murine erythroleukemia cells

Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

Tbx protein level critical for clock-mediated somite positioning is regulated through interaction between Tbx and Ripply

The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation

Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA

Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression

Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord

Wnt proteins promote neuronal differentiation in neural stem cell culture.

Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.

Wnt signalling required for expansion of neural crest and CNS progenitors.

Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression

Wnt-3a regulates somite and tailbud formation in the mouse embryo

Wnt10a is involved in AER formation during chick limb development.

Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.