List of works by Clara Nervi

A highly specific q-RT-PCR assay to address the relevance of the JAK2WT and JAK2V617F expression levels and control genes in Ph-negative myeloproliferative neoplasms

scientific article published on 31 October 2013

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis

scientific article (publication date: 2 December 2005)

A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis

scientific article published on 24 May 2017

A transcriptome-wide approach reveals the key contribution of NFI-A in promoting erythroid differentiation of human CD34(+) progenitors and CML cells.

scientific article published on 29 April 2010

ACTH 1-17 effects in acute myeloid leukemia

scientific article published on 01 April 1984

AML1-ETO triggers epigenetic activation of early growth response gene l, inducing apoptosis in t(8;21) acute myeloid leukemia

scientific article published on 10 January 2014

AML1/ETO cooperates with HIF1α to promote leukemogenesis through DNMT3a transactivation.

scientific article published on 2 March 2015

Acute promyelocytic leukemia: a curable disease.

scientific article

Alterations in expression, binding to ligand and DNA, and transcriptional activity of rearranged and wild-type retinoid receptors in retinoid-resistant acute promyelocytic leukemia cell lines.

scientific article published on October 1996

Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells.

scientific article

Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation ⬇️

scientific article published on July 1, 1992

Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells

scientific article published on 01 August 1997

Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies

scientific article

Control of squamous differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids

scientific article published on January 1, 1992

Dielectric spectroscopy of blood cells suspensions: study on geometrical structure of biological cells.

scientific article published in January 2006

Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.

scientific article published in January 2001

Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming.

scientific article published on 12 June 2008

Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status.

scientific article published on 22 August 2008

Epigenetic role of miRNAs in normal and leukemic hematopoiesis

scientific article published in January 2013

Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

scientific article

Epigenetic treatment of solid tumours: a review of clinical trials

scientific article

Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents.

scientific article published on 07 July 2013

Estrogen receptor expression activates the transcriptional and growth-inhibitory response to retinoids without enhanced retinoic acid receptor alpha expression.

scientific article published on November 1998

Expression of SMRTbeta promotes ligand-induced activation of mutated and wild-type retinoid receptors.

scientific article published on 19 August 2004

Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells

scientific article published on 01 July 1991

Expression of nuclear retinoic acid receptors in wild-type and mutant embryonal carcinoma PCC4.aza1R cells

scientific article published on 01 November 1990

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

scientific article (publication date: 19 February 1998)

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia

article

Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells.

scientific article published in February 2005

Homeobox 1.3 expression: induction by retinoic acid in human bronchial fibroblasts.

scientific article published in July 1992

Hyperplasia and squamous metaplasia in the tracheobronchial epithelium: alterations in the balance of growth and differentiation factors

scientific article published on January 1, 1992

Increased cholesterol sulfate and cholesterol sulfotransferase activity in relation to the multi-step process of differentiation in human epidermal keratinocytes.

scientific article published in February 1989

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

scientific article published on 26 December 2004

Isolation and binding characteristics of nuclear retinoic acid receptors

scientific article published on 01 January 1990

MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.

scientific article published on 21 July 2008

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

scientific article (publication date: 8 February 2002)

MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

scientific article

Molecular signature of retinoic acid treatment in acute promyelocytic leukemia

scientific article

Myc-binding-site recognition in the human genome is determined by chromatin context

scientific article published on 11 June 2006

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.

scientific article published on 19 June 2009

Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein.

scientific article published on September 1993

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

scientific article published in May 2000

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.

scientific article published on August 1997

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.

scientific article published on 28 July 2016

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression.

scientific article published on 10 February 2012

Proliferating and quiescent cells exhibit different subcellular distribution of protein kinase C activity

scientific article published on 01 January 1986

Protein kinase C in cell proliferation and differentiation

scientific article published on 01 January 1988

RARs and microRNAs.

scientific article published on January 2014

Regulation of type I and type II transglutaminase in normal human bronchial epithelial and lung carcinoma cells

scientific article published on 01 July 1992

Retinoic acid receptors: from molecular mechanisms to cancer therapy.

scientific article published on 25 December 2014

Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.

scientific article

Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells ⬇️

scientific article published on July 15, 1992

Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia

scientific article published on 01 September 2006

Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.

scientific article

Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.

scientific article

Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.

scientific article

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

scientific article published in July 2005

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

scientific article published on 18 October 2013

Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination.

scientific article published on 16 August 2012

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

scientific article

Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways

scientific article published on June 2005

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