List of works - Simona Sestito

A patent update on PDK1 inhibitors (2015-present)

scientific article published on 29 March 2019

Areca catechu-From farm to food and biomedical applications

scientific article published on 11 March 2020

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

scientific article published on 31 January 2020

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

scientific article published on 21 April 2015

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

scientific article published on 22 October 2015

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

scientific article published on 27 September 2019

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

scientific article published on 23 December 2019

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

scientific article published on 17 September 2016

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

scientific article published on 31 October 2019

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6

scientific article published on 26 February 2020

Epibatidine: A Promising Natural Alkaloid in Health

article

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.

scientific article published on 27 September 2017

Inhibition of Enterovirus A71 by a Novel 2-Phenyl-Benzimidazole Derivative

scientific article published on 04 January 2021

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

scientific article published on 20 April 2016

Memantine prodrug as a new agent for Alzheimer's Disease

scientific article published on 15 March 2019

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents

scientific article published on 23 April 2019

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease

scientific article published on 4 October 2017

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

scientific article published on 12 December 2017

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

scientific article published on 03 August 2018

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease

scientific article

Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

scientific article published in 2021

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

scientific article published on 29 April 2020

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

scientific article published on 14 May 2019

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

scientific article published on 31 January 2017

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer