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List of works by Karen E Knudsen

2,2-bis(4-chlorophenyl)-1,1-dichloroethylene stimulates androgen independence in prostate cancer cells through combinatorial activation of mutant androgen receptor and mitogen-activated protein kinase pathways

scientific article published in September 2008

2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation

scientific article published on September 2004

A central domain of cyclin D1 mediates nuclear receptor corepressor activity

scientific article

A hormone-DNA repair circuit governs the response to genotoxic insult

scientific article published on 11 September 2013

A patient-derived explant (PDE) model of hormone-dependent cancer

scientific article published on 16 August 2018

A tale of three PKCs: epsilon emerges as a driver of pre-neoplastic phenotypes

scientific article published in February 2011

AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy

scientific article published on 20 February 2014

AR function in promoting metastatic prostate cancer

scientific article published on September 2014

Aberrant BAF57 signaling facilitates prometastatic phenotypes

scientific article

Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68

scientific article

An evaluation of evidence for the carcinogenic activity of bisphenol A.

scientific article published on 28 June 2007

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs

scientific article

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors

scientific article published on 27 April 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

scientific article published on June 2017

Androgen receptor corepressors and prostate cancer

scientific article published on December 2006

BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF.

scientific article published on March 2005

Beyond DNA repair: DNA-PK function in cancer

scientific article

Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer.

scientific article published on December 2006

Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate

scientific article published on 12 May 2011

Cell cycle-coupled expansion of AR activity promotes cancer progression.

scientific article published on 26 September 2016

Cell-cycle-dependent regulation of androgen receptor function

scientific article

Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure

publication published in 2007

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function

scientific article published on June 2015

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling

scientific article (publication date: 15 February 2002)

Consequence of the tumor-associated conversion to cyclin D1b

scientific article published on 18 March 2015

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes

scientific article

Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis

scientific article published on 5 September 2012

Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function

scientific article

Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer.

scientific article

Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer

scientific article

Cyclin D1: mechanism and consequence of androgen receptor co-repressor activity.

scientific article

Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists

scientific article

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation

scholarly article

Cyclin D3 action in androgen receptor regulation and prostate cancer.

scientific article published on 17 December 2007

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

scientific article published on July 2015

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer ⬇️

scientific article

Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells

scientific article published on 5 July 2017

Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors

scientific article published on April 2015

Differential impact of RB status on E2F1 reprogramming in human cancer

scientific article

Differential requirement of SWI/SNF for androgen receptor activity

scientific article published on 29 May 2003

Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression

scientific article published on 13 August 2015

Dual roles of PARP-1 promote cancer growth and progression

scientific article published on 19 September 2012

Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors

scientific article

Ex vivo culture of human prostate tissue and drug development

scientific article published on 11 June 2013

FOXA1: master of steroid receptor function in cancer

scientific article published on 20 September 2011

Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis

scientific article published on 05 October 2009

Fusing transcriptomics to progressive prostate cancer.

scientific article

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Genomic prostate cancer classifier predicts biochemical failure and metastases in patients after postoperative radiation therapy

scientific article

Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer

scientific article published on 20 October 2009

Hormone whodunit: clues for solving the case of intratumor androgen production

scientific article published on 18 August 2014

Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage

scientific article

IGF2 revs the steroidogenesis engine

scientific article

Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene

scientific article

Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen Nanoparticle.

scientific article published on 4 April 2018

Integrative molecular profiling of routine clinical prostate cancer specimens.

scientific article published on 3 March 2015

Linking DNA Damage and Hormone Signaling Pathways in Cancer

scientific article published on March 2016

MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer

scientific article published on 8 May 2018

Middlegame Theory, Cancer Style: A Message from the Editor-in-Chief

scientific article published on 01 January 2013

Mitogenic action of the androgen receptor sensitizes prostate cancer cells to taxane-based cytotoxic insult

scientific article published on December 2006

Models of neuroendocrine prostate cancer

scientific article published on 27 October 2014

Molecular pathogenesis and progression of prostate cancer

scientific article published on June 2013

Multiple G1 Regulatory Elements Control the Androgen-dependent Proliferation of Prostatic Carcinoma Cells ⬇️

scientific article published on August 7, 1998

Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle

scientific article

Novel actions of next-generation taxanes benefit advanced stages of prostate cancer

scientific article

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

scientific article published on 09 August 2018

Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition

scientific article

Outsmarting androgen receptor: creative approaches for targeting aberrant androgen signaling in advanced prostate cancer

scientific article published on May 2011

PARP Inhibitors in Prostate Cancer

scientific article

PARP-1 regulates DNA repair factor availability

scientific article published on 01 December 2018

PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer

scientific article

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

scientific article

Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer

scientific article

Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response

scientific article published on 06 June 2018

Postprostatectomy radiation therapy: an evidence-based review

scientific article published on December 2011

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

scientific article published on 7 July 2017

Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report

scientific article

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells

scientific article

RB Loss Promotes Prostate Cancer Metastasis

scientific article published on 06 December 2016

RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response

scientific article

RB1 Heterogeneity in Advanced Metastatic Castration Resistant Prostate Cancer

scientific article published on 26 September 2018

Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo

scientific article published on 13 November 2017

Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells

scientific article

Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.

scientific article

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

scientific article published on 18 September 2019

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer

scientific article

Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer

scientific article published on 28 July 2009

Tailoring to RB: tumour suppressor status and therapeutic response

scientific article

Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition

scientific article published on October 2013

Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.

scientific article published on 20 December 2017

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer

scientific article

Targeting cell cycle and hormone receptor pathways in cancer.

scientific article published on 27 May 2013

Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression

scientific article published on 18 January 2012

Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity

scientific article published on June 2008

Targeting the p300/CBP Axis in Lethal Prostate Cancer

scientific article published on 11 January 2021

The AR dependent cell cycle: mechanisms and cancer relevance

scientific article published on 12 July 2011

The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer

scientific article published on December 2008

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

scientific article published on 15 January 2021

The complex role of AR signaling after cytotoxic insult: implications for cell-cycle-based chemotherapeutics

scientific article published on 26 June 2007

The cyclin D1b splice variant: an old oncogene learns new tricks

scientific article published on 24 July 2006

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).

scientific article published on 12 June 2013

The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc

scientific article

The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments

scientific article

The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression ⬇️

scientific article published on November 22, 2010

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

scientific article

The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness

scientific article published on 27 August 2014

The role of tumor suppressor dysregulation in prostate cancer progression

scientific article published on April 2013

Therapeutic Challenge With a CDK 4/6 Inhibitor Induces an RB-dependent SMAC Mediated Apoptotic Response in Non-Small Cell Lung Cancer

scientific article published on 8 January 2018

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

scientific article

There and Back Again: The Middle Earth of DNA Repair

scientific article published on October 2016

Time to stratify? The retinoblastoma protein in castrate-resistant prostate cancer

scientific article published on 02 August 2011

Transcriptional roles of PARP1 in cancer

scientific article

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression

scientific article published on 6 November 2013

Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status

scientific article

Xenoestrogen action in breast cancer: impact on ER-dependent transcription and mitogenesis.

scientific article published on 3 December 2005

mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer

scientific article

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