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List of works by Elzbieta Sochacka

2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes

scientific article

A distinctive RNA fold: the solution structure of an analogue of the yeast tRNAPhe T Psi C domain

scientific article

A hydantoin isoform of cyclic N6-threonylcarbamoyladenosine (ct6A) is present in tRNAs

scientific article

Accurate translation of the genetic code depends on tRNA modified nucleosides.

scientific article published on 22 February 2002

Acid-base and metal ion binding properties of 2-thiocytidine in aqueous solution.

scientific article

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products.

scientific article

C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA Codons

scientific article published on 20 April 2020

C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.

scientific article

Chemical Synthesis of Oligoribonucleotide (ASL of tRNALys T. brucei) Containing a Recently Discovered Cyclic Form of 2-Methylthio-N6 -threonylcarbamoyladenosine (ms2 ct6 A)

scientific article published on 22 August 2019

Contribution of dihydrouridine in folding of the D-arm in tRNA

scientific article

Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.

scientific article

DNA binding and cleavage studies of copper(II) complexes with 2'-deoxyadenosine modified histidine moiety

scientific article

Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products

scientific article published on 8 September 2013

Desulfurization of 2-thiouracil nucleosides: conformational studies of 4-pyrimidinone nucleosides

scientific article published on 01 April 2011

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

scientific article

Efficient conversion of N6-threonylcarbamoyladenosine (t6A) into a tRNA native hydantoin cyclic form (ct6A) performed at nucleoside and oligoribonucleotide levels.

scientific article

Efficient synthesis of 2'-deoxyzebularine and its α-anomer by the silyl method of N-glycosylation. Crystal structures and conformational study in solution.

scientific article published on 28 March 2014

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate

scientific article published on 19 June 2018

Formation of the [b+41]+. ion in the mass spectra of 2-thiouridines

scientific article published on 01 June 1980

Histamine modified 2'-deoxyriboadenosine--potential copper binding site in DNAzymes.

scientific article published on 28 January 2010

Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs

scientific article

Impact of histidine residue on chelating ability of 2′-deoxyriboadenosine

scientific article published on 27 May 2011

Modified constructs of the tRNA TPsiC domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferases

scientific article published on March 2000

Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levels

scientific article published on 16 July 2018

Novel enamine derivatives of 5,6-dihydro-2'-deoxyuridine formed in reductive amination of 5-formyl-2'-deoxyuridine.

scientific article published in September 2008

Nucleoside modifications in the regulation of gene expression: focus on tRNA

scientific article

Nucleosides. CXLVIII. Synthesis of 6-(beta-D-ribofuranosyl)picolinamide. A novel C-nucleoside from D-ribonolactone.

scientific article published in February 1988

Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine.

scientific article published on 20 February 2017

Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine.

scientific article published in June 2009

Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast

scientific article published on 01 December 1992

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

scientific article published on 15 June 2017

Role of modified nucleosides of yeast tRNA(Phe) in ribosomal binding

scientific article published in January 2000

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

scientific article (publication date: 15 December 2016)

Single atom modification (O-->S) of tRNA confers ribosome binding.

scientific article published in February 1999

Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry.

scientific article published in January 1995

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

scientific article published on 7 April 2011

Stability studies on the newly discovered cyclic form of tRNA N(6)-threonylcarbamoyladenosine (ct(6)A)

scientific article published on 21 April 2014

Synthesis and properties of uniquely modified oligoribonucleotides: yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions.

scientific article

Synthesis of Nucleobase-Modified RNA Oligonucleotides by Post-Synthetic Approach

scientific article published on 23 July 2020

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions ⬇️

scientific article published on March 24, 2011

The influence of the C5 substituent on the 2-thiouridine desulfuration pathway and the conformational analysis of the resulting 4-pyrimidinone products

scientific article

Transformation of a wobble 2-thiouridine to 2-selenouridine via S-geranyl-2-thiouridine as a possible cellular pathway.

scientific article

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