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List of works by Egon Persson

1H NMR assignment and secondary structure of the Ca2(+)-free form of the amino-terminal epidermal growth factor like domain in coagulation factor X.

scientific article

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

scientific article published on April 2007

A loop of coagulation factor VIIa influencing macromolecular substrate specificity

scientific article published on 11 December 2006

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models ⬇️

scientific article published on January 18, 2013

Activation peptides prolong the murine plasma half-life of human factor VII

scientific article published on 20 January 2011

Allosteric activation of coagulation factor VIIa ⬇️

scientific article published on June 1, 2011

Allosteric activation of coagulation factor VIIa visualized by hydrogen exchange

scientific article published on 10 May 2006

Amino acid residues 721-729 are required for full factor VIII activity

scientific article published on 01 December 1995

Antibody-induced Enhancement of Factor VIIa Activity through Distinct Allosteric Pathways ⬇️

scientific article published on January 24, 2012

Artificial contact pathway activation masks the haemostatic potential of rFVIIa and NN1731 in thrombocytopenic whole blood

scientific article published on 16 March 2010

Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes.

scientific article

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa

scientific article published on 04 December 2019

Ca2+ binding to proteins containing gamma-carboxyglutamic acid residues.

scientific article

Ca2+ binding to the first epidermal growth factor-like domain of factor VIIa increases amidolytic activity and tissue factor affinity

scientific article published on 01 August 1997

Ca2+ in the first epidermal growth factor-like domain of activated factor VII

scientific article published on 01 March 1998

Calcium binding to the isolated beta-hydroxyaspartic acid-containing epidermal growth factor-like domain of bovine factor X.

scientific article published on October 1989

Characterization of chemically crosslinked human factor VIIIa

scientific article published on 01 April 1994

Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study

scientific article published on 07 December 2004

Characterization of the interaction between the light chain of factor VIIa and tissue factor ⬇️

scientific article published on August 18, 1997

Comparison of the Ca2+ binding properties of the gamma-carboxyglutamic acid-containing module of protein Z in the intact protein and in N-terminal fragments

scientific article published on 01 December 1992

Conformational stability of factor VIIa: biophysical studies of thermal and guanidine hydrochloride-induced denaturation

scientific article published on 01 May 1998

Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism

scientific article published on 20 June 2019

Effects of Ca2+ binding on the protease module of factor Xa and its interaction with factor Va. Evidence for two Gla-independent Ca(2+)-binding sites in factor Xa.

scientific article published in October 1993

Enhanced in vitro procoagulant and antifibrinolytic potential of superactive variants of recombinant factor VIIa in severe hemophilia A.

scientific article published in October 2003

Extensive small-angle X-ray scattering studies of blood coagulation factor VIIa reveal interdomain flexibility

scientific article published on 20 October 2010

Factor VII Tokushima (Cys22→Gly) is not γ-carboxylated due to a disrupted γ-carboxylase recognition site

scientific article published on 31 August 2017

Fibrin gel structure obtained with a FVIIa analogue with enhanced FX-activating potential in haemophilia

scientific article published on 01 October 2009

How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

scientific article

Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.

scientific article published on 17 July 2003

In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia

scientific article published on 16 September 2014

Influence of the gamma-carboxyglutamic acid-rich domain and hydrophobic stack of factor VIIa on tissue factor binding

scientific article published on 01 January 1996

Inhibitors of factor VIIa affect the interface between the protease domain and tissue factor

scientific article published on 01 September 2006

Inhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel 2-aryl substituted pyrid

scientific article published on 01 December 2000

Inhibitors of the tissue factor/factor VIIa-induced coagulation: synthesis and in vitro evaluation of novel specific 2-aryl substituted 4H-3,1-benzoxazin-4-ones

scientific article published on 01 August 2000

Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.

scientific article

Isolation of intact modules from noncatalytic parts of vitamin K-dependent coagulation factors IX and X and protein C

scientific article published on 01 January 1993

Kinetics of the interaction between the human factor VIIIa subunits: effects of pH, ionic strength, Ca2+ concentration, heparin, and activated protein C-catalyzed proteolysis

scientific article published on 01 October 1995

Limited factor VIIa surface localization requirement of the factor VIIa-induced overall thrombin generation in platelet-rich hemophilia A plasma

scientific article published on 28 June 2019

Macromolecular substrate affinity for free factor VIIa is independent of a buried protease domain N-terminus

scientific article published on 05 January 2006

Mg(2+) binding to the Gla domain of factor X influences the interaction with tissue factor

scientific article published on 01 September 2007

More efficient reversal of dabigatran inhibition of coagulation by activated prothrombin complex concentrate or recombinant factor VIIa than by four-factor prothrombin complex concentrate

scientific article published on 02 January 2015

Novel molecules for the correction of factor Xa generation and phenotype in hemophilia ⬇️

scientific article published on 08 March 2012

Overestimation of N-glycoPEGylated factor IX activity in a one-stage factor IX clotting assay owing to silica-mediated premature conversion to activated factor IX.

scientific article

Oxidation of methionine residues in coagulation factor VIIa.

scientific article

Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity.

scientific article published in April 2011

Prevention of beta strand movement into a zymogen-like position does not confer higher activity to coagulation factor VIIa.

scientific article

Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa.

scientific article published in August 2001

Protein structural requirements for Ca2+ binding to the light chain of factor X. Studies using isolated intact fragments containing the gamma-carboxyglutamic acid region and/or the epidermal growth factor-like domains.

scientific article published in February 1991

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

scientific article

Reagent-specific underestimation of turoctocog alfa pegol (N8-GP) clotting activity owing to decelerated activation by thrombin

scientific article published on 07 December 2018

Recombinant activated factor VII (rFVIIa): characterization, manufacturing, and clinical development

scientific article

Sequential coagulation factor VIIa domain binding to tissue factor.

scientific article published on 10 October 2005

Site-directed fluorescence probing to dissect the calcium-dependent association between soluble tissue factor and factor VIIa domains.

scientific article published in May 2003

Site-directed mutagenesis but not gamma-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor.

scientific article

Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

scientific article published on 24 October 2014

Spectroscopic probing of the influence of calcium and the gla domain on the interaction between the first EGF domain in factor VIIa and tissue factor

scientific article published on 01 October 2000

Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.

scientific article

Structurally and functionally distinct Ca2+ binding sites in the gamma-carboxyglutamic acid-containing domain of factor VIIa

scientific article published on 01 November 1995

Structure of human coagulation activated factor VII

scientific article published on 01 April 2000

Structure of human factor VIIa and its implications for the triggering of blood coagulation

scientific article

Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.

scientific article published in June 2001

The effect of aspartate hydroxylation on calcium binding to epidermal growth factor-like modules in coagulation factors IX and X

scientific article published on 01 November 1993

The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

scientific article

The gamma-carboxyglutamic acid and epidermal growth factor-like domains of factor X. Effect of isolated domains on prothrombin activation and endothelial cell binding of factor X

scientific article published on 01 February 1991

The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor

scientific article published on 14 October 2014

Thermal effects on an enzymatically latent conformation of coagulation factor VIIa

scientific article published on 01 April 1999

Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding

scientific article published on 01 July 1992

Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes

scientific article published on 12 December 2014

Transition state analysis of the complex between coagulation factor VIIa and tissue factor: suggesting a sequential domain-binding pathway.

scientific article published in February 2005

Variants of recombinant factor VIIa with increased intrinsic activity.

scientific article published on January 2004

Vatreptacog alfa from conception to clinical proof of concept.

scientific article published on 18 February 2012

Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue

scientific article

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