List of works - Juan Miguel Redondo

A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics

scientific article published on 18 February 2016

A major role for RCAN1 in atherosclerosis progression

scientific article published on 15 October 2013

A novel factor distinct from E2F mediates C-MYC promoter activation through its E2F element during exit from quiescence.

scientific article

A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer

scientific article published on 26 April 2015

A robust method for quantitative high-throughput analysis of proteomes by 18O labeling.

scientific article

A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp

scientific article published on 01 May 2000

Activation of the Na+ /K+ -ATPase by interleukin-2

scientific article published on 01 October 1986

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

scientific article

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

scientific article published in Journal of Biological Chemistry

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

scientific article published on 11 May 2021

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

scientific article

Blockade of NFAT activation by the second calcineurin binding site

scientific article published on 06 January 2006

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

scientific article published on November 1997

C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.

scientific article published on 27 July 2015

CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth

scholarly article by Raúl Jiménez-P et al published October 2018 in Haematologica

COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells.

scientific article

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes.

scientific article

Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice

scientific article published on 29 December 2018

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

scientific article published on 27 December 2019

Characterization of p53-mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells

scientific article published on 04 June 2003

Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis

scientific article published on 23 June 2018

Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

scientific article published in Nature Communications

Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.

scientific article published on 21 November 2007

Cyclooxygenase-2: a therapeutic target in angiogenesis.

scientific article

Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation.

scientific article published on 2 February 2018

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

scientific article published on 11 May 2015

Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage.

scientific article published on May 1996

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

scientific article published on 4 January 2002

Expression and function of AIM, an activation inducer molecule of human lymphocytes, is dependent on the activation of protein kinase C

scientific article published on 01 May 1989

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

scientific article published on 12 March 2021

General statistical framework for quantitative proteomics by stable isotope labeling.

scientific article published on 10 February 2014

IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis

scientific article published on 3 July 2012

Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer.

scientific article published in November 1991

Identification of phosphorylation sites in proteins by nanospray quadrupole ion trap mass spectrometry

scientific article published on 01 April 2000

Impact of left ventricular hypertrophy on troponin release during acute myocardial infarction: new insights from a comprehensive translational study

scientific article

In vivo upregulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment.

scientific article published in June 2005

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers ⬇️

scientific article published on November 1, 1992

Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor

scientific article published on 01 April 1990

Inhibition of interleukin 2-induced proliferation of cloned murine T cells by glucocorticoids. Possible involvement of an inhibitory protein

scientific article published on 01 October 1988

Inhibitors of the calcineurin/NFAT pathway.

scientific article published on April 2004

JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes

scientific article published on 01 October 1996

MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter.

scientific article published on September 2017

Macrophage-specific MHCII expression is regulated by a remote enhancer controlled by NFAT5

article

Madrid center not quite in limbo

scientific article published on 01 August 2005

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.

scientific article published on 19 August 2015

NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells

scientific article published on 27 June 2019

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.

scientific article published on 3 June 2011

New Methods for Disease Modeling Using Lentiviral Vectors

scientific article published on 10 September 2018

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

scientific article published on 9 January 2017

Nonlinear optical 3-dimensional method for quantifying atherosclerosis burden

scientific article

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice.

scientific article published on 7 March 2016

PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway.

scientific article published on 9 June 2008

Pentoxifylline inhibits adhesion and activation of human T lymphocytes

scientific article published on 01 July 1998

Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.

scientific article published on 21 August 2014

Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding.

scientific article published on March 2003

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

scientific article

Potentiation of interleukin-2 activity by levamisole and imidazole

scientific article published on 01 January 1987

Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcripti

scientific article published on 01 November 1996

Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α

scientific article published on 01 June 1999

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

scientific article published on 19 July 2012

Regulator of calcineurin 1 mediates pathological vascular wall remodeling

scientific article published on 19 September 2011

Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids.

scientific article published on 5 January 2018

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

scientific article published on 26 June 2007

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

scientific article

Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion

scientific article published on 3 July 2017

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.

scientific article published on 7 April 2016

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38

scientific article published on 3 March 2014

Statistical model to analyze quantitative proteomics data obtained by 18O/16O labeling and linear ion trap mass spectrometry: application to the study of vascular endothelial growth factor-induced angiogenesis in endothelial cells

scientific article

Systematic characterization of phosphorylation sites in NFATc2 by linear ion trap mass spectrometry.

scientific article published on April 2006

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

scientific article

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

scholarly article

The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.

scientific article

The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.

scientific article published on 8 November 2011

The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways

scientific article published in Journal of Biological Chemistry

The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit

scientific article published on 14 June 2005

Transcription initiation sites and promoter structure of the human TRAIL-R3 gene

scientific article (publication date: 6 November 2002)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.

scientific article published on 17 November 2003

Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.

scientific article

[The NFAT transcription factor family as immunosuppression target]

scientific article published on 01 January 2000

c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain.

scientific article published on 2 March 2005

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.

scientific article published on 22 January 2016

List of works by Juan Miguel Redondo

A Novel Systems-Biology Algorithm for the Analysis of Coordinated Protein Responses Using Quantitative Proteomics

A major role for RCAN1 in atherosclerosis progression

A novel factor distinct from E2F mediates C-MYC promoter activation through its E2F element during exit from quiescence.

A novel role for an RCAN3-derived peptide as a tumor suppressor in breast cancer

A robust method for quantitative high-throughput analysis of proteomes by 18O labeling.

A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp

Activation of the Na+ /K+ -ATPase by interleukin-2

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

Blockade of NFAT activation by the second calcineurin binding site

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.

CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth

COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells.

Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes.

Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

Characterization of p53-mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells

Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis

Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone.

Cyclooxygenase-2: a therapeutic target in angiogenesis.

Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation.

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice

Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage.

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

Expression and function of AIM, an activation inducer molecule of human lymphocytes, is dependent on the activation of protein kinase C

Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm

General statistical framework for quantitative proteomics by stable isotope labeling.

IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis

Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer.

Identification of phosphorylation sites in proteins by nanospray quadrupole ion trap mass spectrometry

Impact of left ventricular hypertrophy on troponin release during acute myocardial infarction: new insights from a comprehensive translational study

In vivo upregulation of CD95 and CD95L causes synergistic inhibition of angiogenesis by TSP1 peptide and metronomic doxorubicin treatment.

Indistinguishable nuclear factor binding to functional core sites of the T-cell receptor delta and murine leukemia virus enhancers ⬇️

Induction of T cell activation by monoclonal antibodies specific for the transferrin receptor

Inhibition of interleukin 2-induced proliferation of cloned murine T cells by glucocorticoids. Possible involvement of an inhibitory protein

Inhibitors of the calcineurin/NFAT pathway.

JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes

MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter.

Macrophage-specific MHCII expression is regulated by a remote enhancer controlled by NFAT5

Madrid center not quite in limbo

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.

NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells

NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.

New Methods for Disease Modeling Using Lentiviral Vectors

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.

Nonlinear optical 3-dimensional method for quantifying atherosclerosis burden

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice.

PGE2 induces angiogenesis via MT1-MMP-mediated activation of the TGFbeta/Alk5 signaling pathway.

Pentoxifylline inhibits adhesion and activation of human T lymphocytes

Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.

Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding.

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

Potentiation of interleukin-2 activity by levamisole and imidazole

Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcripti

Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

Regulator of calcineurin 1 mediates pathological vascular wall remodeling

Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids.

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38

Statistical model to analyze quantitative proteomics data obtained by 18O/16O labeling and linear ion trap mass spectrometry: application to the study of vascular endothelial growth factor-induced angiogenesis in endothelial cells

Systematic characterization of phosphorylation sites in NFATc2 by linear ion trap mass spectrometry.

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.

The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.

The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways

The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit

Transcription initiation sites and promoter structure of the human TRAIL-R3 gene

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.

Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression.

[The NFAT transcription factor family as immunosuppression target]