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List of works by Julhash U Kazi

ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.

scientific article published on 10 January 2017

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML.

scientific article published on 21 March 2016

Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression.

scientific article

BEX1 acts as a tumor suppressor in acute myeloid leukemia.

scientific article published on 26 May 2015

Bioinformatic prediction and analysis of eukaryotic protein kinases in the rat genome

scientific article published on 14 December 2007

Brain-Expressed X-linked (BEX) proteins in human cancers.

scientific article published on 23 September 2015

Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma

scientific article published on 16 July 2018

Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.

scientific article published in July 2008

Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity

scientific article published on October 2011

Correction: The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

scientific article published on 25 July 2019

De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

scientific article published on 2 May 2018

Efficacy of the CDK inhibitor dinaciclib in vitro and in vivo in T-cell acute lymphoblastic leukemia.

scientific article

Expression of GADS enhances FLT3-induced mitogenic signaling.

scientific article published in March 2016

FLT3 mutations in patients with childhood acute lymphoblastic leukemia (ALL).

scientific article

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

scientific article published on 29 November 2012

FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications

scientific article published on 01 July 2019

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

scientific article published on 2 February 2016

Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis

scientific article

Glucocorticoid-resistant B cell acute lymphoblastic leukemia displays receptor tyrosine kinase activation

scientific article published on 04 April 2019

Grb10 is a dual regulator of receptor tyrosine kinase signaling

scientific article published on 14 January 2014

HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.

scientific article published on 03 February 2016

Induction of the nuclear proto-oncogene c-fos by the phorbol ester TPA and v-H-Ras.

scientific article published on November 2008

Isoform-specific translocation of PKC isoforms in NIH3T3 cells by TPA.

scientific article published on 8 October 2007

KITD816V Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma

scientific article published on 5 June 2017

Keratin 19 expression correlates with poor prognosis in breast cancer

scientific article published on 26 August 2014

Maximum likelihood analysis of mammalian p53 indicates the presence of positively selected sites and higher tumorigenic mutations in purifying sites.

scientific article published on 24 May 2011

Mechanisms of Anticancer Therapy Resistance: The Role of Cancer Stem Cells

scientific article published on 27 November 2020

Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

scientific article published on 24 October 2019

PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner

scientific article published on 4 June 2015

Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.

scientific article published on 26 June 2013

Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia.

scientific article published on 31 October 2013

Protein kinase C expression is deregulated in chronic lymphocytic leukemia.

scientific article

Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.

scientific article published on 13 March 2015

SOCS proteins in regulation of receptor tyrosine kinase signaling

scientific article published on 05 April 2014

SOCS6 is a selective suppressor of receptor tyrosine kinase signaling

scientific article

SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation

scientific article published on 23 April 2018

SYK is a critical regulator of FLT3 in acute myeloid leukemia

scientific article

Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance.

scientific article

Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.

scientific article

Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling

scientific article published on 21 July 2016

Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling.

scientific article published on 27 November 2013

T-cell Acute Lymphoblastic Leukemia Cells Display Activation of Different Survival Pathways.

scientific article published on 6 November 2017

The ALK inhibitor AZD3463 effectively inhibits growth of sorafenib-resistant acute myeloid leukemia

scholarly article by Sausan A Moharram et al published 15 January 2019 in Blood Cancer Journal

The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.

scientific article published on 11 November 2013

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

scientific article published on 9 September 2015

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

scientific article published on 23 October 2017

The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V.

scientific article

The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL).

scientific article published on 31 January 2017

The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome.

scientific article published on 22 March 2013

The role of HOXB2 and HOXB3 in acute myeloid leukemia.

scientific article published on 16 October 2015

The role of SRC family kinases in FLT3 signaling

scientific article published on 12 December 2018

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD.

scientific article published on 7 March 2017

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