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List of works by Nathan J Pavlos

"Fusion and fission" unveils remarkable insights into osteoclast plasticity

scientific article published on 01 July 2012

A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration.

scientific article published on 15 June 2016

A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

scientific article published on 23 September 2015

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

scientific article

Alexidine Dihydrochloride Attenuates Osteoclast Formation and Bone Resorption and Protects Against LPS-Induced Osteolysis

scientific article published on 12 September 2015

Bafilomycin A1 Attenuates Osteoclast Acidification and Formation, Accompanied by Increased Levels of SQSTM1/p62 Protein

scientific article published on 26 November 2015

Brief exposure to full length parathyroid hormone-related protein (PTHrP) causes persistent generation of cyclic AMP through an endocytosis-dependent mechanism

scientific article published on 30 August 2019

Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity.

scientific article

Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption.

scientific article

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

scientific article published on 26 March 2020

Choline kinase β mutant mice exhibit reduced phosphocholine, elevated osteoclast activity, and low bone mass

scientific article

Circulating Lipocalin 2 Levels Predict Fracture-Related Hospitalizations in Elderly Women: A Prospective Cohort Study

scientific article published on May 2015

Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways

scientific article published on 3 August 2017

Distinct yet overlapping roles of Rab GTPases on synaptic vesicles ⬇️

scientific article published on March 1, 2011

Disulfiram attenuates osteoclast differentiation in vitro: a potential antiresorptive agent

scientific article

EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase.

scientific article

Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclasts.

scientific article published on February 2005

Evidence that human cartilage and chondrocytes do not express calcitonin receptor.

scientific article published on 24 September 2007

Expression Quantitative Trait Locus Study of Bone Mineral Density GWAS Variants in Human Osteoclasts

scientific article published on 23 February 2018

Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcemia

scientific article published on 18 February 2022

GPCR Signaling and Trafficking: The Long and Short of It.

scientific article published on 23 November 2016

Genetic regulatory mechanisms in human osteoclasts suggest a role for the STMP1 and DCSTAMP genes in Paget's disease of bone

scientific article published in Scientific Reports

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes.

scientific article published on 27 April 2016

Identical subchondral bone microarchitecture pattern with increased bone resorption in rheumatoid arthritis as compared to osteoarthritis

scientific article published on 06 September 2014

In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering.

scientific article

Influence of age and gender on microarchitecture and bone remodeling in subchondral bone of the osteoarthritic femoral head.

scientific article published on 17 April 2015

M-CSF potently augments RANKL-induced resorption activation in mature human osteoclasts

scientific article

Membrane trafficking in osteoclasts and implications for osteoporosis

scientific article published on 05 March 2019

Mutations of Vasopressin Receptor 2 Including Novel L312S Have Differential Effects on Trafficking.

scientific article published on 29 June 2016

Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation

scientific article

Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.

scientific article published on 25 March 2009

Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation.

scientific article

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

scientific article published on 25 February 2021

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.

scientific article published on 20 October 2016

Paclitaxel inhibits osteoclast formation and bone resorption via influencing mitotic cell cycle arrest and RANKL-induced activation of NF-κB and ERK.

scientific article

Parathyroid Hormone-Related Protein Negatively Regulates Tumor Cell Dormancy Genes in a PTHR1/Cyclic AMP-Independent Manner.

scientific article

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.

scientific article published on 26 March 2012

Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis

scientific article

Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein.

scientific article

Rab GTPases: Emerging Oncogenes and Tumor Suppressive Regulators for the Editing of Survival Pathways in Cancer

scientific article published on 21 January 2020

Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption

scientific article

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies.

scientific article

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation.

scientific article published on 30 September 2013

Septins are critical regulators of osteoclastic bone resorption

scientific article published in Scientific Reports

Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth

scientific article published on 24 February 2016

Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly

scientific article published on 15 October 2019

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

scientific article

Targeted sequencing of in familial Paget's disease of bone

scientific article published on 21 February 2019

Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption

scientific journal article

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

scientific article

The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions

scientific article published on 25 November 2020

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

scientific article published on 26 March 2021

Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo.

scientific article published on 20 February 2016

Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-қB activation and titanium particle-induced osteolysis in a mouse model

scientific article

V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption ⬇️

scientific article published on May 29, 2012

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