List of works - Go Hirai

A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

scientific article published on 8 September 2016

CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.

scientific article published in May 2013

Comparative Characterization of the Leaf Tissue of Physalis alkekengi and Physalis peruviana Using RNA-seq and Metabolite Profiling

scientific article (publication date: 2016)

Construction of the benzylic quaternary carbon center of zoanthenol by intramolecular Mizoroki-Heck reaction of enone

scientific article published on 01 May 2002

Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation

scientific article

Correction to "Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity"

scientific article published on 28 December 2020

Design and synthesis of protein kinase Cα activators based on ‘out of pocket’ interactions

scientific article published on 28 April 2011

Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.

scientific article

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

scientific article published on 30 May 2019

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation

scientific article published in November 2013

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

scientific article

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

scientific article published on 22 November 2019

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol

scientific article published on 01 September 2008

Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.

scientific article

Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.

scientific article published on 20 April 2015

Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate

scientific article

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

scientific article published on 19 February 2016

Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level

scientific article published on 01 July 2007

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

scientific article published on 06 September 2018

Kinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type Transformations

scientific article published on 15 June 2012

Mimicking/extracting structure and functions of natural products: synthetic approaches that address unexplored needs in chemical biology.

scientific article

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.

scientific article published on 18 March 2014

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions.

scientific article published on 8 November 2016

Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. ⬇️

scientific article

Stereocontrolled and convergent entry to CF2-sialosides: synthesis of CF2-linked ganglioside GM4.

scientific article published on 23 November 2007

Synthesis and preliminary biological evaluation of truncated zoanthenol analogues.

scientific article published in May 2004

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

scientific article published on 20 May 2019

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

scientific article published on 12 February 2019

Synthesis of CH2-Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

scientific article published on 22 February 2019

Synthesis of CH2-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct C-glycosylation

scientific article published on 26 March 2020

Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity

scientific article published on 30 October 2020

Synthesis of polyunsaturated fatty acid-containing glucuronosyl-diacylglycerol through direct glycosylation

Synthesis of the DFGH ring system of type B physalins: highly oxygenated, cage-shaped molecules.

scientific article published in January 2009

Synthesis of the Right-Side Structure of Type B Physalins

scientific article published on 9 November 2016

Synthesis ofCH2-Linked α(2,3)Sialylgalactose Analogue: On the Stereoselectivity of the Key Ireland-Claisen Rearrangement

scientific article published on 03 September 2008

Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling.

scientific article published on 19 February 2018

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

scientific article published on 22 November 2016

Unexpected Diels–Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin

scientific article published on 26 March 2013

Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

scientific article published on 5 July 2017

List of works by Go Hirai

A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells

CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.

Comparative Characterization of the Leaf Tissue of Physalis alkekengi and Physalis peruviana Using RNA-seq and Metabolite Profiling

Construction of the benzylic quaternary carbon center of zoanthenol by intramolecular Mizoroki-Heck reaction of enone

Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation

Correction to "Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity"

Design and synthesis of protein kinase Cα activators based on ‘out of pocket’ interactions

Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Enantioselective synthesis of the fully functionalized ABC ring of zoanthenol

Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.

Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.

Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

Importance of interaction between C1 domain and lipids in protein kinase C alpha activation: hydrophobic side chain direction in isobenzofuranone ligands controls enzyme activation level

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Kinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type Transformations

Mimicking/extracting structure and functions of natural products: synthetic approaches that address unexplored needs in chemical biology.

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions.

Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. ⬇️

Stereocontrolled and convergent entry to CF2-sialosides: synthesis of CF2-linked ganglioside GM4.

Synthesis and preliminary biological evaluation of truncated zoanthenol analogues.

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Synthesis of CH2-Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

Synthesis of CH2-linked α-galactosylceramide and its glucose analogues through glycosyl radical-mediated direct C-glycosylation

Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity

Synthesis of polyunsaturated fatty acid-containing glucuronosyl-diacylglycerol through direct glycosylation

Synthesis of the DFGH ring system of type B physalins: highly oxygenated, cage-shaped molecules.

Synthesis of the Right-Side Structure of Type B Physalins

Synthesis ofCH2-Linked α(2,3)Sialylgalactose Analogue: On the Stereoselectivity of the Key Ireland-Claisen Rearrangement

Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling.

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

Unexpected Diels–Alder/Carbonyl-ene Cascade toward the Biomimetic Synthesis of Chloropupukeananin

Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes