List of works - Laurence Abrami

A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum.

scientific article

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

scientific article published on 10 April 2020

Adventures of a pore-forming toxin at the target cell surface

scientific article

Aerolysin from Aeromonas hydrophila and related toxins

scientific article

Anthrax toxin receptor 2a controls mitotic spindle positioning

scientific article

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

scientific article

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake.

scientific article

Anthrax toxin: the long and winding road that leads to the kill

scientific article

Bacterial subversion of lipid rafts.

scientific article published on February 2004

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome ⬇️

scientific article

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

scientific article

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.

scientific article published on 13 June 2001

Differential sorting and fate of endocytosed GPI-anchored proteins

scientific article

Distribution of mRNA encoding the FA-CHIP water channel in amphibian tissues: effects of salt adaptation

scientific article published in February 1995

Dynamic Radiolabeling of S-Palmitoylated Proteins

scientific article published on 01 January 2019

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

scientific article

Entry of the lymphogranuloma venereum strain of Chlamydia trachomatis into host cells involves cholesterol-rich membrane domains.

scientific article published on January 2003

Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels

scientific article

Functional differentiation of the human red blood cell and kidney urea transporters.

scientific article published in December 1996

Functional expression of the human CHIP28 water channel in a yeast secretory mutant

scientific article published on 01 October 1995

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6.

scientific article

Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies

scientific article

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

scientific article published on 01 January 2020

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin

scientific article

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

scientific article

Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

scientific article

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.

scientific article

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

scientific article published on 01 May 2020

Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

scientific article published on 19 April 2022

Localization of the FA-CHIP water channel in frog urinary bladder

scientific article published on July 1, 1997

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

scientific article

Membrane insertion: The strategies of toxins (review).

scientific article

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.

scholarly article

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

scientific article

Not as simple as just punching a hole

scientific article

Palmitoylated calnexin is a key component of the ribosome-translocon complex

scientific article

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

scholarly article

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

scientific article published on 10 December 2018

Pathogens, toxins, and lipid rafts

article published in 2000

Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin

scientific article

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

scientific article

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

scientific article

Sendai virus budding in the course of an infection does not require Alix and VPS4A host factors

scientific article

Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin.

scientific article

Sequence and functional expression of an amphibian water channel, FA-CHIP: a new member of the MIP family.

scientific article published in June 1994

Surface dynamics of aerolysin on the plasma membrane of living cells

scientific article

SwissPalm: Protein Palmitoylation database.

scientific article published on 16 July 2015

Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum.

scientific article published in April 2009

Targeting STING with covalent small-molecule inhibitors

scientific article published in Nature

The Pore-forming Toxin Proaerolysin Is Activated by Furin ⬇️

scientific article published in Journal of Biological Chemistry

The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction.

scientific article published in February 2002

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

scientific article published on 18 October 2016

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

scientific article published on 03 July 2020

List of works by Laurence Abrami

A pore-forming toxin interacts with a GPI-anchored protein and causes vacuolation of the endoplasmic reticulum.

A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome

Adventures of a pore-forming toxin at the target cell surface

Aerolysin from Aeromonas hydrophila and related toxins

Anthrax toxin receptor 2a controls mitotic spindle positioning

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake.

Anthrax toxin: the long and winding road that leads to the kill

Bacterial subversion of lipid rafts.

CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome ⬇️

Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.

Differential sorting and fate of endocytosed GPI-anchored proteins

Distribution of mRNA encoding the FA-CHIP water channel in amphibian tissues: effects of salt adaptation

Dynamic Radiolabeling of S-Palmitoylated Proteins

Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors

Entry of the lymphogranuloma venereum strain of Chlamydia trachomatis into host cells involves cholesterol-rich membrane domains.

Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels

Functional differentiation of the human red blood cell and kidney urea transporters.

Functional expression of the human CHIP28 water channel in a yeast secretory mutant

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6.

Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies

Hemagglutinin of Influenza A, but not of Influenza B and C viruses is acylated by ZDHHC2, 8, 15 and 20

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

Hyaline fibromatosis syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.

Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

Localization of the FA-CHIP water channel in frog urinary bladder

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Membrane insertion: The strategies of toxins (review).

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

Not as simple as just punching a hole

Palmitoylated calnexin is a key component of the ribosome-translocon complex

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

Pathogens, toxins, and lipid rafts

Plasma membrane microdomains act as concentration platforms to facilitate intoxication by aerolysin

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Sendai virus budding in the course of an infection does not require Alix and VPS4A host factors

Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin.

Sequence and functional expression of an amphibian water channel, FA-CHIP: a new member of the MIP family.

Surface dynamics of aerolysin on the plasma membrane of living cells

SwissPalm: Protein Palmitoylation database.

Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum.

Targeting STING with covalent small-molecule inhibitors

The Pore-forming Toxin Proaerolysin Is Activated by Furin ⬇️

The glycan core of GPI-anchored proteins modulates aerolysin binding but is not sufficient: the polypeptide moiety is required for the toxin-receptor interaction.

Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish