List of works - Younbok Lee

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

scientific article published on 01 October 2018

A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis.

scientific article

A serum microRNA signature for amyotrophic lateral sclersosis reveals convergent RNA processing defects and identifies presymptomatic mutation carriers.

scientific article published in November 2014

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells

scientific article

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

scientific article published on 13 September 2017

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

scientific article

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration.

scientific article published on 25 June 2015

Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic

scientific article

Increased utility in the CNS of a powerful neuron-specific tetracycline-regulatable adenoviral system developed using a post-transcriptional enhancer.

scientific article published in May 2005

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.

scientific article published on 30 July 2012

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

scientific article

Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

scientific article published on 07 March 2019

Optimizing regulatable gene expression using adenoviral vectors.

scientific article

Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.

scientific article

RNA Misprocessing in C9orf72-Linked Neurodegeneration

scientific article published on 11 July 2017

SAFB re-distribution marks steps of the apoptotic process.

scientific article published on 6 July 2007

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

scientific article

Twist-1 regulates the miR-199a/214 cluster during development

scientific article

List of works by Younbok Lee

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis.

A serum microRNA signature for amyotrophic lateral sclersosis reveals convergent RNA processing defects and identifies presymptomatic mutation carriers.

Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration.

Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic

Increased utility in the CNS of a powerful neuron-specific tetracycline-regulatable adenoviral system developed using a post-transcriptional enhancer.

MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.

Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

Optimizing regulatable gene expression using adenoviral vectors.

Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import.

RNA Misprocessing in C9orf72-Linked Neurodegeneration

SAFB re-distribution marks steps of the apoptotic process.

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

Twist-1 regulates the miR-199a/214 cluster during development