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List of works by James Melrose

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

scientific article published on 4 December 2015

Aggrecan, the Primary Weight-Bearing Cartilage Proteoglycan, Has Context-Dependent, Cell-Directive Properties in Embryonic Development and Neurogenesis: Aggrecan Glycan Side Chain Modifications Convey Interactive Biodiversity

scientific article published on 27 August 2020

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

scientific article published on 5 March 2015

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development

scientific article published on 23 May 2012

Colocalization in vivo and association in vitro of perlecan and elastin.

scientific article

Concise Review: Stem/Progenitor Cell Proteoglycans Decorated with 7-D-4, 4-C-3, and 3-B-3(-) Chondroitin Sulfate Motifs Are Morphogenetic Markers of Tissue Development

article

Diverse effects of Perlecan-HS on cell and matrix regulation: Tendon destabilization in Hspg2 Exon 3 null HS deficient mice reveals essential homeostatic roles for HS in cellular regulation and tendon functionality

Diverse effects of Perlecan-HS on cell and matrix regulation: Tendon destabilization in Hspg2 Exon 3 null HS deficient mice reveals essential homeostatic roles for HS in cellular regulation and tendon functionality

Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries ) large destabilizing lesion model of experimental disc degeneration

scientific article published on 10 October 2018

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

scientific article published on 18 January 2019

Fractone Stem Cell Niche Components Provide Intuitive Clues in the Design of New Therapeutic Procedures/Biomatrices for Neural Repair

scientific article published on 05 May 2022

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

scientific article published on 14 July 2008

Functional Consequences of Keratan Sulfate Sulfation in Electrosensory Tissues and in Neuronal Regulation

scientific article published on 13 March 2019

Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair

scientific article published on 01 May 2018

Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.

scientific article

Interleukin-1α induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model

scientific article published on 8 September 2016

Keratan Sulphate, a complex Glycosaminoglycan with Unique Functional Capability

scientific article published on 11 January 2018

Keratan sulfate (KS)-proteoglycans and neuronal regulation in health and disease: the importance of KS-glycodynamics and interactive capability with neuroregulatory ligands

scientific article published on 27 January 2019

Spatiotemporal Expression of 3-B-3(-) and 7-D-4 Chondroitin Sulfation, Tissue Remodeling, and Attempted Repair in an Ovine Model of Intervertebral Disc Degeneration

scientific article published on 03 October 2019

The Glucosinolates: A Sulphur Glucoside Family of Mustard Anti-Tumour and Antimicrobial Phytochemicals of Potential Therapeutic Application

scientific article published on 19 August 2019

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

scientific article published in November 2017

The adolescent idiopathic scoliotic IVD displays advanced aggrecanolysis and a glycosaminoglycan composition similar to that of aged human and ovine IVDs

scientific article published on 13 February 2018

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.

scientific article

The multifaceted roles of perlecan in fibrosis

scientific article published on 20 February 2018

The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc

scientific article published on 13 June 2013

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.

scientific article published on 06 February 2014

The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages

scientific article published on 19 September 2006

Type XI collagen-perlecan-HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis

scientific article published on 16 April 2019

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