List of works - Nuno Palma

A novel approach for assessing macromolecular complexes combining soft-docking calculations with NMR data.

scientific article

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

scientific article

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

scientific article published on 25 January 2012

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

scientific article published in April 2001

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

scientific article published on 11 September 2018

Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

scientific article published in April 2010

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.

scientific article published on 19 September 2014

Evidence for a ternary complex formed between flavodoxin and cytochrome c3: 1H-NMR and molecular modeling studies

scientific article published on 01 May 1994

Ferredoxins

scientific article published on 01 January 1994

Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c553-ferredoxin complex

scientific article

Modelling the Electron-Transfer Complex Between Aldehyde Oxidoreductase and Flavodoxin

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

scientific article (publication date: 21 October 2013)

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

scientific article published in February 2013

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474

scientific article published on 12 February 2020

Structural model of the Fe-hydrogenase/cytochrome c553 complex combining transverse relaxation-optimized spectroscopy experiments and soft docking calculations

scientific article

Structure of the tetraheme cytochrome from Desulfovibrio desulfuricans ATCC 27774: X-ray diffraction and electron paramagnetic resonance studies

scientific article published on 01 October 1995

Synechocystisferredoxin/ferredoxin-NADP+-reductase/NADP+complex: Structural model obtained by NMR-restrained docking

article

Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.

scientific article

The Structure of an Electron Transfer Complex Containing a Cytochromecand a Peroxidase

scientific article published in Journal of Biological Chemistry

List of works by Nuno Palma

A novel approach for assessing macromolecular complexes combining soft-docking calculations with NMR data.

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.

Evidence for a ternary complex formed between flavodoxin and cytochrome c3: 1H-NMR and molecular modeling studies

Ferredoxins

Heteronuclear NMR and soft docking: an experimental approach for a structural model of the cytochrome c553-ferredoxin complex

Modelling the Electron-Transfer Complex Between Aldehyde Oxidoreductase and Flavodoxin

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474

Structural model of the Fe-hydrogenase/cytochrome c553 complex combining transverse relaxation-optimized spectroscopy experiments and soft docking calculations

Structure of the tetraheme cytochrome from Desulfovibrio desulfuricans ATCC 27774: X-ray diffraction and electron paramagnetic resonance studies

Synechocystisferredoxin/ferredoxin-NADP+-reductase/NADP+complex: Structural model obtained by NMR-restrained docking

Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.

The Structure of an Electron Transfer Complex Containing a Cytochromecand a Peroxidase