Search filters

List of works by Herman A Schreuder

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor

scientific article

A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles

scientific article

A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist

scientific article

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.

scientific article published on 26 February 2018

Analysis of the active site of the flavoprotein p-hydroxybenzoate hydroxylase and some ideas with respect to its reaction mechanism

scientific article published on 01 March 1990

Chitinase and beta-1,3-glucanase in the lutoid-body fraction of Hevea latex

scientific article published on September 1996

Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases

scientific article

Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate

scientific article

Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified FAD present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin.

scientific article published on December 1994

Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes

scientific article

Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3 A resolution

scientific article published on 01 October 1992

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton [...]

scientific article

Crystallization and preliminary X-ray analysis of human antithrombin III

scientific article published on 01 January 1993

Crystallization and preliminary crystallographic analysis of antistasin, a leech-derived inhibitor of blood coagulation factor Xa

scientific article published on 01 June 1993

Crystals of soluble interleukin-1 receptor complexed with its natural antagonist reveal a 1:1 receptor-ligand complex

scientific article published on 01 October 1995

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa

scientific article published on 01 December 2004

Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa

scientific article

Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.

scientific article published in April 2003

Determination of beta-galactosidase activity in the intestinal tract of mice by ion-exchange high-performance liquid chromatography using epsilon-N-1-(1-deoxylactulosyl)-L-lysine as substrate

scientific article published on 01 December 1983

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations

scientific article published on 25 June 2018

Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.

scientific article published in January 2009

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

scientific article

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes

scientific article

Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding ⬇️

scientific article published on November 1, 1997

Inhibition of CatA: an emerging strategy for the treatment of heart failure.

scientific article

Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones

scientific article

Interdomain binding of NADPH in p-Hydroxybenzoate Hydroxylase as Suggested by Kinetic, Crystallographic and Modeling Studies of Histidine 162 and Arginine 269 Variants ⬇️

scientific article published on August 14, 1998

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) ⬇️

scientific article published on 8 September 2016

Lys42 and Ser42 variants of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens reveal that Arg42 is essential for NADPH binding

scientific article

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin

scientific article

Novel β-amino acid derivatives as inhibitors of cathepsin A

scientific article

Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability

scientific article

Phe161and Arg166variants ofp-hydroxybenzoate hydroxylase

scholarly article by Michel H.M. Eppink published in January 1999

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.

scientific article published in July 2005

Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis

scientific article

The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa

scientific article published on 31 July 2008

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions ⬇️

scientific article published on January 1, 1994

Paulina is supported by:

About Paulina

Help