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List of works by Anthony K. C. Chan

A Canadian survey of self-infusion practices in persons with haemophilia A.

scientific article published in November 2012

A cross-sectional study evaluating post-thrombotic syndrome in children

scientific article published on 01 January 2003

A novel antithrombin-heparin covalent complex: antithrombotic and bleeding studies in rabbits

scientific article published on 01 October 1998

A practical approach to hemophilia care in children.

scientific article published on May 2007

Activated protein C generation is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium.

scientific article published in February 2004

Adherence with haemophilia treatments: a survey of haemophilia healthcare professionals in Canada.

scientific article published on 22 February 2011

Adsorption of proteins from infant and adult plasma to biomaterial surfaces

scientific article published on 01 June 2002

Age-related differences in heparin response

scientific article published on 19 December 2005

An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots ⬇️

scientific article published on April 14, 2008

An open-label randomized controlled trial of low molecular weight heparin for the prevention of central venous line-related thrombotic complications in children: the PROTEKT trial.

scientific article published in January 2003

Analysis of inhibition rate enhancement by covalent linkage of antithrombin to heparin as a potential predictor of reaction mechanism

scientific article published on 13 December 2006

Analysis of warfarin therapy in pediatric patients: A prospective cohort study of 319 patients

scientific article published on 01 November 1999

Anti-prothrombin antibodies and other acquired antibodies associated with thrombosis in children

scientific article published on 03 August 2009

Anticoagulant mechanisms of covalent antithrombin-heparin investigated by thrombelastography. Comparison with unfractionated heparin and low-molecular-weight heparin

scientific article published on 01 July 2009

Anticoagulation therapy in children.

scientific article published on August 2003

Anticoagulation therapy in neonates, children and adolescents

scientific article

Antithrombin-heparin covalent complex reduces microemboli during cardiopulmonary bypass in a pig model.

scientific article published on 3 September 2010

Antithrombin-heparin covalent complex: a possible alternative to heparin for arterial thrombosis prevention

scientific article published on 01 July 2002

Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

scientific article published on February 2012

Arterial ischemic stroke: experience in Chinese children.

scientific article

Arterial thrombosis in children.

scientific article published on March 2008

Aspirin versus low-molecular-weight heparin for ischemic stroke in children: an unanswered question

scientific article (publication date: August 2002)

Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin.

scientific article

Binding of heparin to metals

scientific article published on 01 April 2011

Binding of heparin to plasma proteins and endothelial surfaces is inhibited by covalent linkage to antithrombin.

scientific article published in May 2004

Biodistribution of covalent antithrombin-heparin complexes

scientific article published on 01 April 2006

Bleeding disorders in neonates

scientific article published on 01 July 2010

Blood-compatible biomaterials by surface coating with a novel antithrombin-heparin covalent complex.

scientific article published in January 2002

Body mass index and thromboembolism in children with hematological malignancies

scientific article published on 06 January 2012

Capillary whole blood monitoring of oral anticoagulants in children in outpatient clinics and the home setting

scientific article published on 01 July 2000

Central venous access device insertion and perioperative management of patients with severe haemophilia A: a local experience

scientific article published on September 2015

Central venous line dysfunction is an independent predictor of poor survival in children with cancer

scientific article published on 01 April 2012

Cerebral sinus venous thrombosis during childhood acute lymphoblastic leukemia therapy: Risk factors and management.

scientific article published on 29 June 2017

Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease

scientific article

Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity.

scientific article published on 9 October 2015

Chemical-physical characterization of polyurethane catheters modified with a novel antithrombin-heparin covalent complex

scientific article published on 01 January 2011

Chronic performance of polyurethane catheters covalently coated with ATH complex: a rabbit jugular vein model.

scientific article published on 16 June 2006

Clinical features and outcome of pulmonary embolism in children

scientific article published on 17 June 2008

Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study

scientific article published on 29 March 2014

Clinical probability score and D-dimer estimation lack utility in the diagnosis of childhood pulmonary embolism

scientific article published on 11 August 2009

Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B

scientific article (publication date: 7 September 2011)

Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass

scientific article published on 01 February 1997

Comparing bleed frequency and factor concentrate use between haemophilia A and B patients ⬇️

scientific article published on February 22, 2011

Comparison of N-linked glycosylation of protein C in newborns and adults

scientific article published on 02 November 2012

Comparison of recombinant and plasma-derived antithrombin biodistribution in a rabbit model

scientific article published on 01 August 2009

Covalent antithrombin-heparin complexes with high anticoagulant activity. Intravenous, subcutaneous, and intratracheal administration

scientific article published on 01 August 1997

Covalent antithrombin-heparin complexes.

scientific article published on 14 September 2006

Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va

scientific article published on 09 March 2010

Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes. Characterization of novel anticoagulants

scientific article published on 01 December 1998

Craniocervical arterial dissection in children: clinical and radiographic presentation and outcome.

scientific article

Decreased concentrations of heparinoids are required to inhibit thrombin generation in plasma from newborns and children compared to plasma from adults due to reduced thrombin potential

scientific article published on 01 April 2002

Definition of post-thrombotic syndrome following lower extremity deep venous thrombosis and standardization of outcome measurement in pediatric clinical investigations.

scientific article published on March 2012

Determination of alpha-2-macroglobulin complexes by a new immuno-activity assay

scientific article published on 16 August 2011

Developing a tracking system for coagulation factor concentrates in southern Ontario.

scientific article published on May 2003

Diagnosis and management of neonatal purpura fulminans ⬇️

scientific article published on August 11, 2011

Diagnosis and treatment of intracranial hemorrhage in children with hemophilia.

scientific article published on January 2013

Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy? ⬇️

scientific article published on July 26, 2012

Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin-sodium) in pediatric patients.

scientific article published in January 2003

Dr. M. Patricia Massicotte Obituary

scientific article published on 11 November 2020

Effect of a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium.

scientific article published in June 1998

Effect of covalent antithrombin-heparin complex on developmental mechanisms in the lung.

scientific article published on 26 December 2008

Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor

scientific article published on 10 June 2010

Effect of covalent serpin-heparinoid complexes on plasma thrombin generation on fetal distal lung epithelium.

scientific article published in February 2003

Effect of substrate and fibrin polymerization inhibitor on determination of plasma thrombin generation in vitro

scientific article published on 21 June 2006

Emergence of the primary pediatric stroke center: impact of the thrombolysis in pediatric stroke trial

scientific article published on 10 June 2014

Enoxaparin for neonatal thrombosis: a call for a higher dose for neonates.

scientific article published on 18 January 2008

Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry.

scientific article

Epidemiology and clinical risk factors predisposing to thromboembolism in children with cancer.

scientific article published in December 2008

Evaluation of an automated method for measuring von Willebrand factor activity in clinical samples without ristocetin

scientific article published on 01 June 2014

Evaluation of the use of low-molecular-weight heparin in neonates: a retrospective, single-center study.

scientific article published on 10 March 2013

Exercise-induced deep vein thrombosis of the upper extremity. 2. A case series in children.

scientific article

Experience with central venous access devices (CVADs) in the Canadian hemophilia primary prophylaxis study (CHPS).

scientific article published on July 2015

Factor XIII deficiency management: a review of the literature.

scientific article published on April 2014

Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates

scientific article published on 16 July 2015

Fetal and neonatal outcome of exposure to anticoagulants during pregnancy.

scientific article published in January 1993

Fibrinolytic response to venous occlusion is decreased in patients after Kawasaki disease

scientific article published on 01 February 2003

Fibrinolytic system in adolescents: response to venous occlusion stress tests.

scientific article published in February 2003

First analysis of 10-year trends in national factor concentrates usage in haemophilia: data from CHARMS, the Canadian Hemophilia Assessment and Resource Management System

scientific article

Frequency, predictors, and neurologic outcomes of vaso-occlusive strokes associated with cardiac surgery in children

scientific article published on 01 December 2008

Glycolytic ATP fuels the plasma membrane calcium pump critical for pancreatic cancer cell survival.

scientific article published on 24 October 2013

Hemophilia prophylaxis adherence and bleeding using a tailored, frequency-escalated approach: The Canadian Hemophilia Primary Prophylaxis Study

scientific article published on 29 January 2020

Heparin Brand Is Associated With Postsurgical Outcomes in Children Undergoing Cardiac Surgery ⬇️

scientific article published on January 5, 2012

How I manage heavy menstrual bleeding ⬇️

scientific article published on 06 July 2013

How to use unfractionated heparin to treat neonatal thrombosis in clinical practice

scientific article

Immobilization of an antithrombin-heparin complex on gold: anticoagulant properties and platelet interactions

scientific article published on 28 January 2011

Immune tolerance induction for a patient with factor IX inhibitors--a case report.

scientific article published on 2 September 2010

Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies.

scientific article published on 08 September 2008

Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.

scientific article

Impaired fibrinolytic activity is present in children with dyslipidemias

scientific article published on 22 January 2004

In vivo rabbit acute model tests of polyurethane catheters coated with a novel antithrombin-heparin covalent complex.

scientific article

Incidence and Management of Thrombotic and Thromboembolic Complications Following the Norwood Procedure

scientific article

Incidence and Management of Thrombotic and Thromboembolic Complications Following the Superior Cavopulmonary Anastomosis Procedure: A Literature Review.

scientific article published in January 2017

Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children

scientific article published on 01 January 2004

Influence of activated factor VII concentrates on thrombin generation in full-term and preterm neonates

scientific article published on 01 April 2000

Influence of exogenous factor VIIa on thrombin generation in cord plasma of full-term and pre-term newborns

scientific article published on 01 June 2000

Influence of mechanical stretch on thrombin regulation by fetal mixed lung cells

scientific article published on 01 September 1998

Inherited Thrombophilia in Childhood Arterial Stroke: Data from Lebanon ⬇️

scientific article published on September 1, 2011

Inhibition of fibrin-bound thrombin by a covalent antithrombin-heparin complex

scientific article published on 01 August 2002

Inhibition of plasmin generation in plasma by heparin, low molecular weight heparin, and a covalent antithrombin-heparin complex

scientific article published on 24 November 2016

Interactions of heparin and a covalently-linked antithrombin-heparin complex with components of the fibrinolytic system

scientific article published on 19 September 2013

Investigation of the anticoagulant mechanisms of a covalent antithrombin-heparin complex

scientific article published on 01 December 1998

Isoform composition of antithrombin in a covalent antithrombin-heparin complex.

scientific article published in October 2003

Longer blood storage is associated with suboptimal outcomes in high-risk pediatric cardiac surgery.

scientific article published on 2 December 2011

Low-molecular-weight heparin in pediatric patients.

scientific article

Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex

scientific article published on 19 April 2012

Mechanisms Responsible for Catalysis of the Inhibition of Factor Xa or Thrombin by Antithrombin Using a Covalent Antithrombin-Heparin Complex ⬇️

scientific article published on April 14, 2003

Mechanisms responsible for the failure of protamine to inactivate low-molecular-weight heparin.

scientific article published in January 2002

Modification of polyurethane surface with an antithrombin-heparin complex for blood contact: influence of molecular weight of polyethylene oxide used as a linker/spacer.

scientific article published on 22 December 2011

Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency.

scientific article published on 21 April 2016

Monitoring Unfractionated Heparin (UFH) therapy: which Anti-Factor Xa assay is appropriate?

scientific article published on 21 November 2006

Morphologic and biochemical features affecting the antithrombotic properties of the inferior vena cava of rabbit pups and adult rabbits.

scientific article published in January 1998

Morphological and biochemical features affecting the antithrombotic properties of the aorta in adult rabbits and rabbit pups

scientific article published on 01 May 1998

Musculoskeletal health of subjects with hemophilia A treated with tailored prophylaxis: Canadian Hemophilia Primary Prophylaxis (CHPS) Study

scientific article published in March 2013

Myocardial Infarction in Neonates: A Review of an Entity with Significant Morbidity and Mortality

scientific article

Natural history of arterial and venous thrombosis in children treated with low molecular weight heparin: a longitudinal study by ultrasound.

scientific article

Need for a new paediatric post thrombotic sequelae outcome measure for non-extremity thrombosis.

scientific article published on 20 April 2011

Neonatal Campylobacter fetus meningitis: a report of an unusual case

scientific article published on 01 April 1992

Neonatal Systemic Venous Thrombosis ⬇️

scientific article published on November 12, 2010

Neonatal and childhood right atrial thrombosis: critical clot size.

scientific article published in June 2013

Neonatal and childhood right atrial thrombosis: recognition and a risk-stratified treatment approach.

scientific article published on June 2010

Neonatal and infant pulmonary thromboembolism: a literature review

scientific article published on October 2012

Neonatal central venous catheter thrombosis: diagnosis, management and outcome.

scientific article

Neonatal central venous catheter thrombosis: diagnosis, management, and outcome.

scientific article

Neonatal portal vein thrombosis: diagnosis and management.

scientific article published on 16 September 2011

Nonacog beta pegol (N9-GP) in hemophilia B: First report on safety and efficacy in previously untreated and minimally treated patients

scientific article published on 29 July 2020

Opinions in pediatric and adolescent gynecology. Does oral contraceptive therapy do more harm than good in adolescents who are receiving chemotherapy?

scientific article published on 01 December 2003

Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study.

scientific article

Patent foramen ovale and stroke in childhood: A systematic review of the literature.

scientific article

Pediatric edition thrombosis research

scientific article published on 02 November 2005

Pediatric thrombophilia.

scientific article published on December 2013

Pharmacokinetics of recombinant and plasma-derived factor IX products in pediatric patients with severe hemophilia B.

scientific article published in January 2015

Pharmacokinetics of recombinant and plasma-derived factor VIII products in paediatric patients with severe haemophilia A.

scientific article published on 19 November 2013

Point of care ultrasonography in haemophilia care: recommendations for training and competency evaluation

scientific article published on 24 July 2015

Polyurethane modified with an antithrombin‐heparin complex via polyethylene oxide linker/spacers: Influence of PEO molecular weight and PEO‐ATH bond on catalytic and direct anticoagulant functions ⬇️

scientific article published on May 28, 2012

Protamine requirements in cardiac surgery: effect of changes in the heparin reference standard

scientific article

Protein adsorption on polyurethane catheters modified with a novel antithrombin-heparin covalent complex

scientific article published on 01 January 2007

Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease

scientific article published on 01 May 2003

Prothrombotic disorders and ischemic stroke in children.

scientific article

Randomized, controlled trial of individualized heparin and protamine management in infants undergoing cardiac surgery with cardiopulmonary bypass

scientific article published on 01 November 2010

Recommendations for developing uniform laboratory monitoring of heparinoid anticoagulants in children

scientific article published on 01 January 2012

Recommendations for the assessment of non-extremity venous thromboembolism outcomes: communication from the SSC of the ISTH.

scientific article

Recommendations for the development of new anticoagulant drugs for pediatric use: communication from the SSC of the ISTH.

scientific article

Reversal of anti-thrombin activity using protamine sulfate. Experience in a neonate with a 10-fold overdose of enoxaparin

scientific article published on 31 October 2006

Risk factors for central venous catheter-related thrombosis in children: a retrospective analysis.

scientific article

Risk, clinical features, and outcomes of thrombosis associated with pediatric cardiac surgery

scientific article published on 12 September 2011

Safety of anticoagulants in children with arterial ischemic stroke.

scientific article published on 7 December 2011

Sedentary Time and Screen-Based Sedentary Behaviors of Children With a Chronic Disease.

scientific article published on 10 November 2014

Selective cleavage of heparin using aqueous 2-hydroxypyridine: production of an aldose-terminating fragment with high anticoagulant activity

scientific article published on 09 June 2006

Spontaneous neonatal arterial thromboembolism: infants at risk, diagnosis, treatment, and outcomes.

scientific article published on December 2013

Stability and sterility of recombinant tissue plasminogen activator at -30 degrees C

scientific article published on 01 June 2000

Standardization of post-thrombotic syndrome definition and outcome assessment following upper venous system thrombosis in pediatric practice.

scientific article published on October 2012

Stroke in children with cardiac disease: report from the International Pediatric Stroke Study Group Symposium

scientific article published on 05 October 2014

Structural Effects of a Covalent Linkage Between Antithrombin and Heparin: Covalent N-Terminus Attachment of Heparin Enhances the Maintenance of Antithrombin's Activated State

scientific article published on 01 August 2006

Supportive care in pediatric cancer: the road to prevention of thrombosis.

scientific article published on 05 March 2014

Surface modification of polydimethylsiloxane with a covalent antithrombin-heparin complex to prevent thrombosis.

scientific article published on 15 April 2014

The Edoxaban Hokusai VTE PEDIATRICS Study: An open-label, multicenter, randomized study of edoxaban for pediatric venous thromboembolic disease

scientific article published on 25 May 2020

The Role of the Vessel Wall ⬇️

scientific article published on January 1, 2013

The association of platelets with failed patent ductus arteriosus closure after a primary course of indomethacin or ibuprofen: a systematic review and meta-analysis.

scientific article

The importance of haemophilia treatment centre administrators in patient care.

scientific article

The influence of age on in vitro plasmin generation in the presence of fibrin monomer

scientific article published on 01 January 2006

The use of alteplase to restore patency of central venous lines in pediatric patients: a cohort study

scientific article published on 01 July 2001

The use of elastic compression stockings for post-thrombotic syndrome in a child

scientific article published on 01 September 2009

The use of prophylaxis in 2663 children and adults with haemophilia: results of the 2006 Canadian national haemophilia prophylaxis survey.

scientific article

Thrombin Generation ⬇️

scientific article published on 01 January 2013

Thromboembolic disease and antithrombotic therapy in newborns.

scientific article

Thromboembolism in children with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute protocols: effect of age and risk stratification of disease.

scientific article published in June 2005

Thromboembolism in children with lymphoma

scientific article published on 30 January 2008

Thromboembolism in children with sarcoma.

scientific article published in August 2007

Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial.

scientific article

Thrombolysis in pediatric stroke study.

scientific article

Thrombosis and embolism in pediatric cardiomyopathy ⬇️

scientific article published on April 1, 2013

Thrombosis and thromboembolic complications in fontan patients: a literature review

scientific article published on 24 January 2014

Thrombosis in Children ⬇️

scientific article published on December 20, 2011

Thrombosis in children with acute lymphoblastic leukemia treated at a tertiary care center in Lebanon: revisiting the role of predictive models.

scientific article

Thrombosis in children with acute lymphoblastic leukemia. Part II. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: effects of the disease and therapy.

scientific article published on January 2003

Thrombosis in children with acute lymphoblastic leukemia: part I. Epidemiology of thrombosis in children with acute lymphoblastic leukemia.

scientific article published on January 2003

Thrombotic complications and thromboprophylaxis across all three stages of single ventricle heart palliation

scientific article published on 17 April 2012

To anticoagulate? Controversy in the management of thrombotic complications of head & neck infections.

scientific article

Transfusion premedication practices among pediatric health care practitioners in Canada: results of a national survey

scientific article published on 16 June 2016

Treatment decision-making among Canadian youth with severe haemophilia: a qualitative approach.

scientific article published on 9 October 2014

Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme.

scientific article published in May 2007

Trimming of peripherally inserted central venous catheters may increase the risk of thrombosis

scientific article published on 01 January 2004

Undetected factor VIII in a patient with type 3 von Willebrands disease mistaken as severe haemophilia A.

scientific article

Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored with anti-factor Xa levels

scientific article published on 01 March 2012

Updates in thrombosis in pediatrics: where are we after 20 years?

scientific article published on January 2012

Urgent clinical challenges in children with ischemic stroke: analysis of 1065 patients from the 1-800-NOCLOTS pediatric stroke telephone consultation service

scientific article (publication date: 2006)

Utility of aPTT in monitoring unfractionated heparin in children

scientific article published on 31 October 2007

Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia.

scientific article published in September 2007

Validity, reliability, and responsiveness of a new measure of health-related quality of life in children with immune thrombocytopenic purpura: the Kids' ITP Tools.

scientific article

Venous thrombosis in children

scientific article published on 01 March 2008

Venous thrombosis in children.

scientific article

Volutrauma activates the clotting cascade in the newborn but not adult rat.

scientific article

What should men living with haemophilia need to know? The perspectives of Canadian men with haemophilia.

scientific article published on 20 November 2013

What should men living with severe haemophilia need to know? The perspectives of Canadian haemophilia health care providers.

scientific article

Whole blood heparin concentrations do not correlate with plasma antifactor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass

scientific article published on 01 June 2000

c.1058C>T variant in theSERPINC1gene is pathogenic for antithrombin deficiency

article

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