List of works - Alexander Leitner

A mass spectrometry-based hybrid method for structural modeling of protein complexes

scientific article published on 09 February 2014

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

scientific article published on 27 January 2020

A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research

scientific article published on 26 August 2017

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

scientific article published on May 2008

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

scientific article published on 26 July 2018

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

scientific article

Applications of chemical tagging approaches in combination with 2DE and mass spectrometry

scientific article published on January 2009

Architecture and conformational switch mechanism of the ryanodine receptor

scientific article

Architecture and functional dynamics of the pentafunctional AROM complex

scientific article published on 06 July 2020

Architecture of the large subunit of the mammalian mitochondrial ribosome

scientific article

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

scientific article published on 17 June 2014

Chemical tagging strategies for mass spectrometry-based phospho-proteomics

scientific article published on January 2009

Chemistry meets proteomics: the use of chemical tagging reactions for MS-based proteomics

scientific article published on October 2006

Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes

scientific article published on 01 July 2019

Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-

scientific article published in August 2005

Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

scientific article published on 14 July 2010

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics

scientific article published on 12 March 2014

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling

scientific article

Cross-link guided molecular modeling with ROSETTA

scientific article

Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology

scientific article published on 26 April 2016

Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines

scientific article

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation

scientific article published on 02 September 2019

Current chemical tagging strategies for proteome analysis by mass spectrometry

scientific article

Derivatisation of arginine residues with malondialdehyde for the analysis of peptides and protein digests by LC-ESI-MS/MS

scientific article published on 01 May 2006

Development of an indole-based chemically cleavable linker concept for immobilizing bait compounds for protein pull-down experiments.

scientific article

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

scientific article published on 04 May 2022

Enrichment Strategies in Phosphoproteomics

scientific article published on January 2016

Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.

scientific article published on 7 October 2004

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

scientific article published on 13 September 2018

Expanding the Cross-Link Coverage of a Carboxyl-Group Specific Chemical Cross-Linking Strategy for Structural Proteomics Applications

scientific article published on 05 January 2021

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

scientific article published on 27 January 2012

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

scientific article published on 8 July 2012

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

scientific article published on 22 May 2019

Functional probing of arginine residues in proteins using mass spectrometry and an arginine-specific covalent tagging concept

scientific article published in July 2005

Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

scientific article published on 22 March 2016

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

scientific article published on 09 July 2020

Identification of marker proteins for the adulteration of meat products with soybean proteins by multidimensional liquid chromatography-tandem mass spectrometry

scientific article published on 01 September 2006

Improving fragmentation of poorly fragmenting peptides and phosphopeptides during collision-induced dissociation by malondialdehyde modification of arginine residues

scientific article published on 01 July 2007

Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation

scientific article

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics

scientific article published on 16 May 2017

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

scientific article published in 2023

Integrative structural investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

scientific article published on 30 January 2018

Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model

scientific article

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

scientific article published on 19 December 2013

Malondialdehyde tagging improves the analysis of arginine oligomers and arginine-containing dendrimers by HPLC-MS.

scientific article published in February 2008

Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing

scientific article published on 30 March 2016

Mass spectrometry supported determination of protein complex structure

scientific article

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

scientific article published in December 2017

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

scientific article published on 01 September 2019

Molecular Architecture of Yeast Chromatin Assembly Factor 1.

scientific article published on 25 May 2016

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

scientific article

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

scientific article

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2

scientific article published in Nature Communications

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

scientific article published on 22 June 2021

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment.

scientific article published on 8 February 2009

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

scientific article published in Journal of Biological Chemistry

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics

scientific article

Probing of arginine residues in peptides and proteins using selective tagging and electrospray ionization mass spectrometry

scientific article published in August 2003

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment

scientific article published in April 2010

Proteomic identification of a marker signature for MAPKi resistance in melanoma

scientific article published on 26 June 2019

Puf6 primes 60S pre-ribosome nuclear export at low temperature

scientific article published on 04 August 2021

Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine

scientific article published on 18 January 2012

Reaction of the indole group with malondialdehyde: application for the derivatization of tryptophan residues in peptides.

scientific article published on 17 August 2007

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome

scientific article

Selective enrichment of tryptophan-containing peptides from protein digests employing a reversible derivatization with malondialdehyde and solid-phase capture on hydrazide beads.

scientific article published on 27 July 2007

Silica-based monolithic columns with mixed-mode reversed-phase/weak anion-exchange selectivity principle for high-performance liquid chromatography

scientific article published on 01 May 2006

SnapShot: mass spectrometry for protein and proteome analyses

scientific article

Solid-phase capture and release of arginine peptides by selective tagging and boronate affinity chromatography.

scientific article

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

scientific article

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

scientific article published on 31 March 2016

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

scientific article published on 3 April 2023

Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS

scientific article published on 27 March 2017

Structure of a human cap-dependent 48S translation pre-initiation complex.

scientific article published in February 2018

Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells

scientific article

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

scientific article published on 04 April 2019

The complete structure of the large subunit of the mammalian mitochondrial ribosome

scientific article

The human GID complex engages two independent modules for substrate recruitment

scientific article published on 14 October 2021

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

scientific article

The mzIdentML data standard version 1.2, supporting advances in proteome informatics.

scientific article

The structure and symmetry of radial spoke protein complex in Chlamydomonas flagella

scientific article published on 21 July 2020

Tools for analyzing the phosphoproteome and other phosphorylated biomolecules: a review

scientific article published on 19 July 2011

Use of the arginine-specific butanedione/phenylboronic acid tag for analysis of peptides and protein digests using matrix-assisted laser desorption/ionization mass spectrometry

scientific article

Visual documentation of the stability of intravenous solutions of omeprazole (Losec) and pantoprazole (Pantoloc)

scientific article

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

scientific article

List of works by Alexander Leitner

A mass spectrometry-based hybrid method for structural modeling of protein complexes

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

Applications of chemical tagging approaches in combination with 2DE and mass spectrometry

Architecture and conformational switch mechanism of the ryanodine receptor

Architecture and functional dynamics of the pentafunctional AROM complex

Architecture of the large subunit of the mammalian mitochondrial ribosome

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Chemical tagging strategies for mass spectrometry-based phospho-proteomics

Chemistry meets proteomics: the use of chemical tagging reactions for MS-based proteomics

Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes

Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-

Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling

Cross-link guided molecular modeling with ROSETTA

Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology

Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation

Current chemical tagging strategies for proteome analysis by mass spectrometry

Derivatisation of arginine residues with malondialdehyde for the analysis of peptides and protein digests by LC-ESI-MS/MS

Development of an indole-based chemically cleavable linker concept for immobilizing bait compounds for protein pull-down experiments.

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

Enrichment Strategies in Phosphoproteomics

Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

Expanding the Cross-Link Coverage of a Carboxyl-Group Specific Chemical Cross-Linking Strategy for Structural Proteomics Applications

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

Functional probing of arginine residues in proteins using mass spectrometry and an arginine-specific covalent tagging concept

Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Identification of marker proteins for the adulteration of meat products with soybean proteins by multidimensional liquid chromatography-tandem mass spectrometry

Improving fragmentation of poorly fragmenting peptides and phosphopeptides during collision-induced dissociation by malondialdehyde modification of arginine residues

Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

Integrative structural investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

Malondialdehyde tagging improves the analysis of arginine oligomers and arginine-containing dendrimers by HPLC-MS.

Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing

Mass spectrometry supported determination of protein complex structure

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

Molecular Architecture of Yeast Chromatin Assembly Factor 1.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment.

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics

Probing of arginine residues in peptides and proteins using selective tagging and electrospray ionization mass spectrometry

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment

Proteomic identification of a marker signature for MAPKi resistance in melanoma

Puf6 primes 60S pre-ribosome nuclear export at low temperature

Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine

Reaction of the indole group with malondialdehyde: application for the derivatization of tryptophan residues in peptides.

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome

Selective enrichment of tryptophan-containing peptides from protein digests employing a reversible derivatization with malondialdehyde and solid-phase capture on hydrazide beads.

Silica-based monolithic columns with mixed-mode reversed-phase/weak anion-exchange selectivity principle for high-performance liquid chromatography

SnapShot: mass spectrometry for protein and proteome analyses

Solid-phase capture and release of arginine peptides by selective tagging and boronate affinity chromatography.

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS

Structure of a human cap-dependent 48S translation pre-initiation complex.

Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

The complete structure of the large subunit of the mammalian mitochondrial ribosome

The human GID complex engages two independent modules for substrate recruitment