List of works - Franz-Josef Meyer-Almes

A Fluorescence-Lifetime-Based Binding Assay for Class IIa Histone Deacetylases.

scientific article published on 6 December 2016

A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ligand probe

scientific article published on 29 May 2014

Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase

scientific article published on 01 April 2014

Compact, cost-efficient microfluidics-based stopped-flow device

scientific article

Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.

scientific article published on 29 November 2016

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets

scientific article

Determination of the binding mechanism of histone deacetylase inhibitors

scientific article published on 30 December 2018

Discrimination between conformational selection and induced fit protein-ligand binding using Integrated Global Fit analysis.

scientific article published on 4 November 2015

Fluorescence cross-correlation: a new concept for polymerase chain reaction

scientific article published on 01 August 1998

Fluorescence lifetime based bioassays.

scientific article

Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A.

scientific article

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

scientific article published on 04 January 2007

Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime.

scientific article

Impact of binding mechanism on selective inhibition of histone deacetylase isoforms.

scientific article published on 14 June 2017

Kinetic binding assays for the analysis of protein-ligand interactions

scientific article published on 15 September 2015

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors

scientific article published on 2 June 2014

Mechanism of binding of the inhibitor (E)-3-(furan-2-yl)-N-hydroxyacrylamide to a histone deacetylase-like amidohydrolase.

scientific article published in February 2010

Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks

scientific article published in 2021

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation

scientific article

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases

scientific article published on 03 May 2009

Novel fluorescence based receptor binding assay method for receptors lacking ligand conjugates with preserved affinity: study on estrogen receptor alpha.

scientific article published in January 2003

Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.

scientific article published on 21 February 2017

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors.

scientific article published on 9 November 2016

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa

scientific journal article

Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases

scientific article

Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase.

scientific article published on 24 October 2014

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. ⬇️

scientific article

The cis-state of an azobenzene photoswitch is stabilized through specific interactions with a protein surface.

scientific article published on 9 February 2015

The cyclic AMP receptor promoter DNA complex: a comparison of crystal and solution structure by quantitative molecular electrooptics

scientific article published on 01 June 1997

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

scientific article published on 27 September 2018

The structure of the RNA polymerase-promoter complex. DNA-bending-angle by quantitative electrooptics.

scientific article

The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket

scientific article published on 4 April 2017

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes

scientific article published in March 2014

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

scientific article published on 09 September 2019

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

scientific article published on 15 January 2013

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.

scientific article

List of works by Franz-Josef Meyer-Almes

A Fluorescence-Lifetime-Based Binding Assay for Class IIa Histone Deacetylases.

A fluorescence lifetime-based binding assay for acetylpolyamine amidohydrolases from Pseudomonas aeruginosa using a [1,3]dioxolo[4,5-f][1,3]benzodioxole (DBD) ligand probe

Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase

Compact, cost-efficient microfluidics-based stopped-flow device

Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets

Determination of the binding mechanism of histone deacetylase inhibitors

Discrimination between conformational selection and induced fit protein-ligand binding using Integrated Global Fit analysis.

Fluorescence cross-correlation: a new concept for polymerase chain reaction

Fluorescence lifetime based bioassays.

Highly ligand efficient and selective N-2-(Thioethyl)picolinamide histone deacetylase inhibitors inspired by the natural product psammaplin A.

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime.

Impact of binding mechanism on selective inhibition of histone deacetylase isoforms.

Kinetic binding assays for the analysis of protein-ligand interactions

Kinetic method for the large-scale analysis of the binding mechanism of histone deacetylase inhibitors

Mechanism of binding of the inhibitor (E)-3-(furan-2-yl)-N-hydroxyacrylamide to a histone deacetylase-like amidohydrolase.

Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks

New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases

Novel fluorescence based receptor binding assay method for receptors lacking ligand conjugates with preserved affinity: study on estrogen receptor alpha.

Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa.

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors.

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa

Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases

Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase.

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. ⬇️

The cis-state of an azobenzene photoswitch is stabilized through specific interactions with a protein surface.

The cyclic AMP receptor promoter DNA complex: a comparison of crystal and solution structure by quantitative molecular electrooptics

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

The structure of the RNA polymerase-promoter complex. DNA-bending-angle by quantitative electrooptics.

The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes

Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.