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List of works by Rob Robey

A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein

scientific article published on 12 September 2019

A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar).

scientific article published on September 2001

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

scientific article published in June 2001

A high-throughput cell-based assay for inhibitors of ABCG2 activity

scientific article published on 20 February 2006

A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.

scientific article

A pharmacodynamic study of the P-glycoprotein antagonist CBT-1® in combination with paclitaxel in solid tumors.

scientific article published on 13 March 2012

A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine

scientific article

A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma

scientific article

A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist.

scientific article

A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer

scientific article published on 20 January 2020

A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities.

scientific article published on February 2006

ABC Transporters: Unvalidated Therapeutic Targets in Cancer and the CNS ⬇️

scientific article published on October 1, 2010

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates

scientific article published on September 2005

ABCG2 is expressed in late spermatogenesis and is associated with the acrosome

scientific article

ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

scientific article published on 9 April 2004

ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy

scientific article published on 8 February 2005

ABCG2: a perspective.

scientific article

ABCG2: determining its relevance in clinical drug resistance

scientific article published on March 2007

ABCG2: structure, function and role in drug response

scientific article published on 01 January 2008

Accommodating Thread-Level Heterogeneity in Coupled Parallel Applications

article

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

scientific article

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

scientific article

Arginine 383 is a crucial residue in ABCG2 biogenesis

scientific article

Assessment of drug transporter function using fluorescent cell imaging

scientific article

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival.

scientific article published on 14 August 2008

Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

scientific article published on 29 March 2007

Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis.

scientific article published on 23 May 2018

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

scientific article published on 09 January 2009

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.

scientific article published on 13 September 2016

Botryllamides: natural product inhibitors of ABCG2

scientific article published in August 2009

CCR 20th Anniversary Commentary: Expanding the Epigenetic Therapeutic Portfolio.

scientific article published in May 2015

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells

scientific article

Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.

scientific article published on July 2005

Characterization of gene rearrangements leading to activation of MDR-1.

scientific article published on 5 September 2006

Chemoresistance in the clinic: overview 1994.

scientific article published on December 1994

Clinical Reversal of Multidrug Resistance

scientific article published on 01 January 1996

Clinical reversal of multidrug resistance

scientific article published on 01 January 1996

Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function

scientific article published on 02 May 2019

Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib

scientific article

Cross-resistance of cisplatin selected cells to anti-microtubule agents: Role of general survival mechanisms

scientific article published on 22 October 2020

Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL.

scientific article published on September 1998

Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines

scientific article

Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.

scientific article published on January 2002

Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein.

scientific article

Efflux of rhodamine from CD56+ cells as a surrogate marker for reversal of P-glycoprotein-mediated drug efflux by PSC 833

scientific article published on 01 January 1999

Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance

scientific article published on November 2007

Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2.

scientific article published on October 2009

Evidence for microtubule target engagement in tumors of patients receiving ixabepilone

scientific article published on December 2007

Expression of mdr-1 in refractory lymphoma: quantitation by polymerase chain reaction and validation of the assay ⬇️

scientific article published on August 15, 1995

FR901228 causes mitotic arrest but does not alter microtubule polymerization

scientific article published on 01 July 2000

Flow cytometric analysis of breast cancer resistance protein expression and function.

scientific article published in June 2002

HG-829 is a potent noncompetitive inhibitor of the ATP-binding cassette multidrug resistance transporter ABCB1

scientific article

Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells

scientific article published in March 2002

Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin

scientific article

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

scientific article published on September 2002

Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration

scientific article published on 28 November 2012

Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter

scientific article

Histone deacetylase inhibitors: emerging mechanisms of resistance.

scientific article published on 7 October 2011

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.

scientific article

Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen

scientific article published on 24 July 2009

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

scientific article

In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent

scientific article published in December 2005

Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

scientific article published in March 2006

Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478

scientific article

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.

scientific article

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

scientific article

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

scientific article published in November 2001

Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

scientific article

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

scientific article

Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2

scientific article published on October 2008

Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer

scientific article published on 27 May 2020

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

scientific article published on 12 April 2014

Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells

scientific article published on 01 July 2000

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors.

scientific article published on 07 August 2013

Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest

scientific article published on March 1, 2003

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

scientific article

Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells

scientific article published in July 2001

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

scientific article published on 26 March 2013

MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia

scientific article published on 01 September 2006

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors

scientific article published on November 2002

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

scientific article

Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells

scientific article published on 2 July 2012

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

scientific article

Model systems for studying the blood-brain barrier: Applications and challenges

scientific article published on 18 May 2019

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

scientific article

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models

scientific article published on 13 January 2020

Mutational analysis of ABCG2: role of the GXXXG motif

scientific article published on July 2004

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

scientific article

Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization

scientific article published in April 2006

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

scientific article published in November 2003

Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale

scientific article published on 04 February 2020

New inhibitors of ABCG2 identified by high-throughput screening

scientific article

Normal p53 status and function despite the development of drug resistance in human breast cancer cells

scientific article published on 01 November 1995

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells

scientific article

Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

scientific article published on September 2002

Overlapping substrate and inhibitor specificity of human and murine ABCG2. ⬇️

scientific article published on 18 July 2013

P-glycoprotein--a clinical target in drug-refractory epilepsy?

scientific article

Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death.

scientific article published in March 2002

Pancreatic Cancer: "A Riddle Wrapped in a Mystery inside an Enigma".

scientific article published in April 2017

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

scientific article

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

scientific article

Pheophorbide a is a specific probe for ABCG2 function and inhibition.

scientific article published in February 2004

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

scientific article published on 06 May 2019

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

scientific article

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

scientific article

Rapid detection of ABC transporter interaction: potential utility in pharmacology.

scientific article

Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression

scientific article published on June 1997

Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.

scientific article

Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines

scientific article published on April 2001

Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin.

scientific article published on March 2012

Reversal of multidrug resistance: lessons from clinical oncology.

scientific article

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

scientific article published in November 1999

Revisiting the role of ABC transporters in multidrug-resistant cancer.

scientific article published on 11 April 2018

Rigosertib induces mitotic arrest and apoptosis in RAS-driven rhabdomyosarcoma and neuroblastoma

scientific article published on 06 November 2020

Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.

scientific article

Self‐Assembled Verteporfin Nanoparticles for Photodynamic and Light‐Independent Therapy in Glioblastoma

scientific article published on 28 September 2024

Side population analysis using a violet-excited cell-permeable DNA binding dye.

scientific article

Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

scientific article

Single nucleotide polymorphisms modify the transporter activity of ABCG2.

scientific article published on 19 April 2005

Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).

scientific article

Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression

scientific article published on 22 April 2019

Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.

scientific article published on 29 October 2008

Survivin Is Not Induced by Novel Taxanes

article

Survivin is not induced by novel taxanes

scientific article

T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance

scientific article published on 2 March 2004

Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models

scientific article published on 21 December 2018

The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant.

scientific article

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

scientific article published on July 2006

The challenge of exploiting ABCG2 in the clinic.

scientific article

The controversial role of ABC transporters in clinical oncology.

scientific article published on September 2011

The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.

scientific article

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport.

scientific article published on 26 December 2015

The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2.

scientific article published on 30 June 2006

The role of half-transporters in multidrug resistance

scientific article

Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe.

scientific article

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

scientific article published in July 2003

Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

scientific article published on 25 February 2011

Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles

scientific article published on 01 November 1998

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