List of works - Ralph A. DeFronzo

1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia

scientific article published on 01 September 1980

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

article

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

scientific article

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors

scientific article published in October 2004

A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study

scientific article published on 01 January 1996

A novel experimental model for human mixed acinar-ductal pancreatic cancer

scientific article published on 2 November 2017

A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study

scientific article published on 20 January 2015

A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin

scientific article published on 01 December 1995

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

scientific article

A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies

scientific article published on 12 April 2006

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

scientific article published on October 2003

A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man

scientific article published on May 1, 1977

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS

scientific article published on 01 June 2016

AMP-activated protein kinase: Role in metabolism and therapeutic implications

scientific article published on November 2006

ANALYSIS OF DOUBLE-TRACER GLUCOSE KINETICS IN HUMANS DURING ORAL GLUCOSE TOLERANCE TEST

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway

scientific article

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor

scientific article

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

scientific article published in December 2002

Actos Now for the prevention of diabetes (ACT NOW) study

scientific article

Acute effect of human recombinant insulin-like growth factor I on renal function in humans

scientific article published on 01 January 1995

Acute renal failure in multiple myeloma

scientific article published on 01 May 1975

Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms

scientific article published in October 2007

Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin

scientific article

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

scientific article

Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: an index of β-cell function in obese adults

scientific article

Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics ⬇️

scientific article published on June 1, 1984

Adrenergic modulation of potassium metabolism during exercise in normal and diabetic humans

scientific article published on 01 January 1987

Adrenergic modulation of potassium metabolism in uremia

scientific article published in February 1990

Aeromonas septicemia from hepatobiliary disease

scientific article published in April 1973

Altered hypothalamic function in response to glucose ingestion in obese humans

scientific article

Amino acid and glucose metabolism in the postabsorptive state and following amino acid ingestion in the dog.

scientific article published in August 1986

Amino acid metabolism in uremia: insights gained from normal and diabetic man.

scientific article published in July 1980

Analysis of Metabolic Parameters as Predictors of Risk in the RENAAL Study ⬇️

scientific article published on May 1, 2003

Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose

scientific article

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.

scientific article published on 29 August 2006

Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

scientific article published on 17 December 2020

Association of genetic variation in ENPP1 with obesity-related phenotypes

scientific article published on 08 May 2008

Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

scientific article

Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.

scientific article published in August 2008

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

scientific article published on April 2009

Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake ⬇️

scientific article published on 01 June 1995

Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW

scientific article

Bedtime insulin/daytime glipizide. Effective therapy for sulfonylurea failures in NIDDM.

scientific article published in February 1995

Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice

scientific article

Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

scientific article

Bicarbonate kinetics in humans: identification and validation of a three-compartment model

scientific article published on 01 July 1995

Biomedical imaging research opportunities workshop IV: a white paper

scientific article published on February 2007

Bromocriptine: a novel approach to the treatment of type 2 diabetes.

scientific article published in August 2000

Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes

scientific article

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2017 EXECUTIVE SUMMARY.

scientific article published on 17 January 2017

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2018 EXECUTIVE SUMMARY.

scientific article published on 17 January 2018

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2016 EXECUTIVE SUMMARY.

scientific article published on January 2016

Carbohydrate metabolism in uremia: a review ⬇️

scientific article published on September 1, 1973

Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived?

scientific article published in July 2017

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

scientific article published on January 2004

Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus

scientific article

Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes

scientific article published on 04 June 2013

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

scientific article

Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates

scientific article

Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney

scientific article published on May 1997

Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.

scientific article published in March 1999

Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals

scientific article

Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

scientific article published on June 2009

Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin

scientific article published on 21 July 2020

Clinical disorders of hyperkalemia

scientific article published on January 1982

Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes

scientific article published on 27 March 2020

Combination Therapy With Exenatide Plus Pioglitazone Versus Basal/Bolus Insulin in Patients With Poorly Controlled Type 2 Diabetes on Sulfonylurea Plus Metformin: The Qatar Study

scientific article published on 17 January 2017

Combination Therapy with Pioglitazone/Exenatide Improves Beta Cell Function and Produces Superior Glycemic Control Compared to Basal/Bolus Insulin in Poorly Controlled T2DM: 3-Year Follow-up of the Qatar Study

scientific article published on 30 July 2020

Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor

scientific article

Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney

scientific article published on 09 October 2013

Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

scientific article published in November 2006

Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans

scientific article published on 01 June 1995

Comparison of thermogenic effect of fructose and glucose in normal humans

scientific article published on 01 June 1986

Contribution of muscle and liver to glucose-fatty acid cycle in humans

scientific article published on 01 April 1993

Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose

scientific article

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates

scientific article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

scientific article

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats

scientific article

Current issues in the treatment of type 2 diabetes. Introduction.

scientific article

Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going

scientific article published on March 2010

Dapagliflozin lowers plasma glucose concentration and improves β-cell function

scientific article published on 24 February 2015

Decreased basal hepatic glucose uptake in impaired fasting glucose

scientific article published on 22 March 2017

Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range

scientific article published on 13 November 2007

Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients

scientific article

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

scientific article published in July 2008

Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study

scientific article published on 10 December 2009

Determinants of the increase in ketone concentration during SGLT2 inhibition in NGT, IFG and T2DM patients

scientific article

Diabetes Incidence and Glucose Tolerance after Termination of Pioglitazone Therapy: Results from ACT NOW.

scientific article

Diabetes in the elderly: not just "normal aging"

scientific article published on 01 May 1984

Diabetic ketoacidosis: diagnosis and treatment.

scientific article

Diabetic nephropathy

scientific article published on 01 January 1994

Diabetic nephropathy--can it be prevented?

scientific article published on 01 May 1996

Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects

scientific article published in July 2008

Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects

scientific article published on 01 November 1987

Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion

scientific article published on 01 May 1991

Differential effects of amino acid and ketoacid on protein metabolism in humans

scientific article published on 01 January 2000

Differential responsiveness of protein synthesis and degradation to amino acid availability in humans.

scientific article published in April 1996

Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man.

scientific article

Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.

scientific article

Direct observation of glycogen synthesis in human muscle with 13C NMR

scientific article

Discordance Between Central (Brain) and Pancreatic Action of Exenatide in Lean and Obese Subjects

scientific article published on 3 August 2016

Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes

scientific article

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

scientific article

Dissociation of the effects of epinephrine and insulin on glucose and protein metabolism

scientific article published on 01 January 1990

Distinct β-cell defects in impaired fasting glucose and impaired glucose tolerance

scientific article published on February 2012

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

scientific article

Dopaminergic regulation of extrarenal potassium metabolism

scientific article published on 01 January 1987

Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans

scientific article published on 01 November 1990

Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans

scientific article published on 01 August 1991

Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects

scientific article published in December 2004

Dose-response effect of elevated plasma free fatty acid on insulin signaling

scientific article published in June 2005

Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes

scientific article

Durability of Triple Combination Therapy Versus Stepwise Addition Therapy in Patients With New-Onset T2DM: 3-Year Follow-up of EDICT

scientific article published on 03 December 2020

Dysfunctional fat cells, lipotoxicity and type 2 diabetes

scientific article

Early metabolic defects in Arab subjects with strong family history of Type 2 diabetes.

scientific article

Effect of Acute Physiological Elevations of Insulin on Circulating Androgen Levels in Nonobese Women* ⬇️

scientific article published on April 1, 1991

Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance

scientific article published on 13 September 2018

Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males

scientific article published on 14 January 2016

Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects

scientific article

Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects.

scientific article published on 25 March 2013

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

scientific article

Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study

scientific article

Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

scientific article

Effect of acute metabolic acidemia on renal electrolyte transport in man ⬇️

scientific article published on August 1, 1979

Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo

scientific article published on 11 March 2008

Effect of alpha-adrenergic blockers, ACE inhibitors, and calcium channel antagonists on renal function in hypertensive non-insulin-dependent diabetic patients

scientific article published on 01 January 1996

Effect of amino acid infusion on renal hemodynamics in humans

scientific article published on 01 July 1986

Effect of amino acid infusion on renal hemodynamics in humans: a dose-response study

scientific article published on 01 November 1994

Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man ⬇️

scientific article published on March 1, 1984

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

scientific article published on October 1987

Effect of dietary protein on in vivo insulin action and liver glycogen repletion.

scientific article published in August 1989

Effect of epinephrine on renal potassium excretion in the isolated perfused rat kidney

scientific article published on 01 August 1984

Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects

scientific article published on 16 March 2011

Effect of fatty acids on glucose production and utilization in man ⬇️

scientific article published on November 1, 1983

Effect of free fatty acids on blood amino acid levels in human.

scientific article published in June 1986

Effect of glyburide on glycemic control, insulin requirement, and glucose metabolism in insulin-treated diabetic patients

scientific article published on 01 February 1987

Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man

scientific article published on 01 May 1980

Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats

scientific article published in June 1998

Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats

scientific article

Effect of hyperketonemia on renal ammonia excretion in man.

scientific article published on August 1986

Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats.

scientific article published in April 1990

Effect of insulin and glucose on feeding behavior.

scientific article published in September 1985

Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis

scientific article published in September 1991

Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis

scientific article published on December 1987

Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.

scientific article published in July 1992

Effect of insulin on renal potassium metabolism

scientific article published on 01 January 1987

Effect of insulin on system A amino acid transport in human skeletal muscle

scientific article

Effect of insulin on the distribution and disposition of glucose in man.

scientific article

Effect of insulinopenia and adrenal hormone deficiency on acute potassium tolerance ⬇️

scientific article published on 01 May 1980

Effect of long chain triglyceride infusion on glucose metabolism in man

scientific article published on 01 November 1982

Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans

scientific article published on 01 August 1989

Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.

scientific article published in April 1990

Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects

scientific article published in May 2002

Effect of physical training on insulin action in obesity.

scientific article published in December 1987

Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis ⬇️

scientific article published on August 1, 1991

Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients

scientific article published in June 2002

Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial

scientific article

Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney disease

scientific article published on 5 December 2007

Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients

scientific article published in September 2004

Effect of plasma amino acid and hormone concentrations on renal plasma flow and glomerular filtration rate

scientific article published on 01 January 1988

Effect of prolonged overnight fasting on energy metabolism in non-insulin-dependent diabetic and non-diabetic subjects.

scientific article published in July 1990

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

scientific article published in December 2001

Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals

scientific article

Effect of somatostatin-induced insulinopenia on glucose oxidation in man.

scientific article published in October 1983

Effect of specific amino acid groups on renal hemodynamics in humans

scientific article

Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus.

scientific article published in June 1991

Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study

scientific article published on January 1991

Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man

article published in 1994

Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.

scientific article

Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney

scientific article published on April 1985

Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension.

scientific article published in June 1995

Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

scientific article published in May 2005

Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin

scientific article

Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle

scientific article published on 01 July 1999

Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects

scientific article published on May 2011

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus

scientific article

Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus

scientific article published on 23 May 2007

Effects of physiological hyperinsulinemia on the intracellular metabolic partition of plasma glucose

scientific article

Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus

scientific article

Effects of plasma amino acid and hormone levels on renal hemodynamics in humans

scientific article published on 01 September 1988

Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus

scientific article published on June 2012

Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents

scientific article published on 04 August 2008

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study

scientific article published on 22 September 2008

Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes

scientific article published on 14 March 2012

Efficacy of Exenatide Plus Pioglitazone Vs Basal/Bolus Insulin in T2DM Patients With Very High HbA1c

scientific article published in February 2017

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial

scientific article published on August 2015

Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial

scientific article published in August 2005

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.

scientific article published in August 1995

Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: effect of weight loss after gastric banding

scientific article published on 24 September 2008

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects

scientific article published on 15 July 2008

Empagliflozin Treatment is Associated with Improved Beta Cell Function in T2DM.

scientific article published on 12 January 2018

Empagliflozin and Kinetics of Renal Glucose Transport in Healthy Individuals and Individuals With Type 2 Diabetes.

scientific article published on 20 April 2017

Empagliflozin and linagliptin combination therapy for treatment of patients with type 2 diabetes mellitus

scientific article

Endogenous Glucose Production and Hormonal Changes in Response to Canagliflozin and Liraglutide Combination Therapy.

scientific article published on 30 March 2018

Energy cost of glucose storage in human subjects during glucose-insulin infusions ⬇️

scientific article published on 01 March 1983

Epinephrine and potassium homeostasis ⬇️

scientific article published on 01 July 1981

Epinephrine-induced insulin resistance in man.

scientific article published on March 1980

Erratum. Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived? Diabetes Care 2017;40:813-820.

scientific article

Erratum. Combination Therapy With Exenatide Plus Pioglitazone Versus Basal/Bolus Insulin in Patients With Poorly Controlled Type 2 Diabetes on Sulfonylurea Plus Metformin: The Qatar Study. Diabetes Care 2017;40:325-331.

scientific article published on 14 June 2017

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models

scientific article published on 23 September 2011

Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors

scientific article published on 08 January 2020

Evidence for the existence of a pineal-adrenal and a pineal-thyroid axis ⬇️

scientific article published on May 1, 1972

Exenatide improves both hepatic and adipose tissue insulin resistance: A dynamic positron emission tomography study.

scientific article

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Extrarenal potassium homeostasis

scientific article published on April 1981

Failure of hyperketonemia to alter basal and insulin-mediated glucose metabolism in man.

scientific article published in March 1986

Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion.

scientific article published on 27 February 2007

Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.

scientific article published in April 1989

Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study

scientific article

Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance

scientific article published on 17 July 2012

First approved inhaled insulin therapy for diabetes mellitus

scientific article published on January 2007

Follow-up report on the diagnosis of diabetes mellitus

scientific article published on November 2003

Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle

scientific article published on 01 March 1994

Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans

scientific article

Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes

scientific article published in October 2002

Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q

article

Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents

scientific article published on 20 February 2018

Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function

scientific article published on 05 September 2013

Genetic epidemiology of cardiometabolic risk factors and their clustering patterns in Mexican American children and adolescents: the SAFARI Study

scientific article published on 05 June 2013

Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children

scientific article published on 17 May 2017

Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study

scientific article published on 17 October 2008

Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and confirmation of a major susceptibility locus on chromosome 6q14.1.

scientific article

Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.

scientific article published in September 2002

Glucagon physiology and aging: evidence for enhanced hepatic sensitivity

scientific article published on 01 July 1983

Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

scientific article published on 27 October 2016

Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods.

scientific article published in November 1994

Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids

scientific article published on 01 February 1992

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance

scientific article

Glucose and insulin metabolism in cirrhosis

scientific article published on January 1989

Glucose and insulin metabolism in uremia.

scientific article

Glucose clamp technique: a method for quantifying insulin secretion and resistance

scientific article

Glucose intolerance and aging

scientific article published on July 1981

Glucose intolerance following chronic metabolic acidosis in man ⬇️

scientific article published on April 1, 1979

Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin

scientific article published on August 1978

Glucose intolerance in uremia: site and mechanism

scientific article published on 01 July 1980

Glucose kinetics: an update and novel insights into its regulation by glucagon and GLP-1.

scientific article

Glucose lowering and vascular protective effects of cycloset added to GLP-1 receptor agonists in patients with type 2 diabetes

scientific article published on 15 August 2018

Glucose metabolism and the kidney

scientific article published on September 1990

Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp

scientific article published on 01 June 1993

Glucose metabolism in cirrhosis: a review with some perspectives for the future

scientific article published on December 1989

Glucose toxicity

scientific article published on 01 June 1990

Glucose transport in human skeletal muscle. The in vivo response to insulin

scientific article published on 01 January 1993

Glucose-Mediated Glucose Disposal at Baseline Insulin is Impaired in IFG

scientific article published on 01 January 2019

Glycogen depletion during prolonged exercise: influence of glucose, fructose, or placebo

scientific article published on 01 March 1985

Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods

scientific article

Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons

scientific article published on 17 January 2017

Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog

scientific article published on 01 May 1985

Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog.

scientific article published on September 1985

Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.

scientific article published in October 1982

Hepatic response to enteral and parenteral glucose in the dog

scientific article published on January 1, 1979

High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive

scientific article published in August 2011

Hormone-substrate changes with exenatide plus dapagliflozin versus each drug alone: The randomized, active-controlled DURATION-8 study

scientific article published on 08 October 2019

Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non-insulin-dependent diabetic parents.

scientific article published in October 1997

Hyperfiltration and diabetic nephropathy: is it the beginning? Or is it the end?

scientific article published on May 1990

Hyperglucagonemia and insulin-mediated glucose metabolism

scientific article

Hyperglycaemia and absorption of sulphonylurea drugs

scientific article published on 01 July 1989

Hyperkalemia and hyporeninemic hypoaldosteronism

scientific article

Hypoadiponectinemia Is Closely Associated with Impaired Nitric Oxide Synthase Activity in Skeletal Muscle of Type 2 Diabetic Subjects ⬇️

scientific article published on October 1, 2010

Hypoglycemic counterregulation in normal and diabetic man.

scientific article published on January 1984

Hypophosphatemia and glucose intolerance.

scientific article

Hypophosphatemia and glucose intolerance: evidence for tissue insensitivity to insulin.

scientific article published in November 1980

IGF-I increases forearm blood flow without increasing forearm glucose uptake.

scientific article

Identification of individuals with insulin resistance using routine clinical measurements

scientific article

Impact of ethnicity and obesity on insulin resistance in two ethnic groups at very high risk of type 2 diabetes.

scientific article

Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes

scientific article published on 10 June 2015

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates.

scientific article published on 11 December 2012

Impaired Renal Tubular Potassium Secretion in Sickle Cell Disease

scientific article published on March 1, 1979

Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose

scientific article published on 8 May 2011

Impaired fasting glucose and impaired glucose tolerance: implications for care

scientific article

Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control

scientific article published on 06 April 2018

Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

scientific article

Impaired renal tubular potassium secretion in systemic lupus erythematosus

scientific article published on 01 March 1977

Impairment of insulin-mediated glucose metabolism by hyperosmolality in man.

scientific article

Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone

scientific article published in April 2001

Improved insulin sensitivity in patients with type I diabetes mellitus after CSII.

scientific article

Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monother

scientific article

Improving efficacy of diabetes management using treatment algorithms in a mainly Hispanic population

scientific article

In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase

scientific article published on January 1997

In vivo actions of peroxisome proliferator-activated receptors: glycemic control, insulin sensitivity, and insulin secretion

scientific article published on August 2013

In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension.

scientific article published in May 1993

In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies

scientific article published on 01 December 1987

In vivo insulin action in genetic models of hypertension

scientific article published on February 1, 1992

Increase in Endogenous Glucose Production With SGLT2 Inhibition Is Unchanged by Renal Denervation and Correlates Strongly With the Increase in Urinary Glucose Excretion

scientific article published on 06 March 2020

Increased Insulin Sensitivity and Insulin Binding to Monocytes after Physical Training ⬇️

scientific article published on November 29, 1979

Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.

scientific article published in March 1996

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects

scientific article published on 20 December 2017

Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training

scientific article published on 01 December 1982

Indirect calorimetry: methodological and interpretative problems

scientific article published on March 1990

Influence of basal androgen levels in euandrogenic women on glucose homeostasis

scientific article published on December 1, 1992

Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings

scientific article published on February 1978

Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man

scientific article published on 01 November 1990

Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis

scientific article published on July 2003

Influence of fibre ingestion on carbohydrate utilization and absorption ⬇️

scientific article published on 01 August 1982

Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man

scientific article published on 01 November 1977

Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia

scientific article published on 01 February 1988

Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange ⬇️

scientific article published on October 1, 1978

Influence of plasma glucose and insulin concentration on plasma glucose clearance in man

scientific article published on 01 August 1982

Inherited Tubule Disorders ⬇️

scientific article published on 01 February 1982

Inhibition of Renal Sodium-Glucose Cotransport With Empagliflozin Lowers Fasting Plasma Glucose and Improves β-Cell Function in Subjects With Impaired Fasting Glucose.

scientific article published on 13 June 2017

Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus

scientific article

Inhibitory effect of epinephrine on renal potassium secretion: a micropuncture study

scientific article published on 01 September 1983

Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes

scientific article published on 07 January 2015

Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding ⬇️

scientific article published on July 1, 1978

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

scientific article published on 01 December 2019

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications

scientific article published on 10 October 2017

Insulin Resistance, Hyperinsulinemia, and Coronary Artery Disease: A Complex Metabolic Web ⬇️

scientific article published on January 1, 1992

Insulin action in uremia.

scientific article

Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity

scientific article published on 01 February 1996

Insulin and renal sodium handling: clinical implications

scientific article published on 01 January 1981

Insulin reduces plasma arginase activity in type 2 diabetic patients

scientific article

Insulin resistance and coronary artery disease.

scientific article published in November 1996

Insulin resistance and diabetes mellitus

scientific article published on September 1996

Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases

scientific article

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

scientific article published on February 2000

Insulin resistance in diabetic ketoacidosis.

scientific article

Insulin resistance in liver disease and portal hypertension

scientific article published on January 1, 1992

Insulin resistance in noncirrhotic idiopathic portal hypertension

scientific article published on 01 January 1991

Insulin resistance in uremia

scientific article published on February 1981

Insulin resistance in uremia mediated by postbinding defects.

scientific article

Insulin resistance in uremia: an in vivo and in vitro study.

scientific article

Insulin resistance is a prominent feature of insulin-dependent diabetes

scientific article published on 01 September 1982

Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects

scientific article published on 23 November 2004

Insulin resistance, hypertension and cellular ion transport systems

scientific article published in 1992

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

scientific article

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

scientific article published on March 1991

Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis

scientific article published on May 1997

Insulin resistance: a universal finding in diabetic states.

scientific article published in January 1981

Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study

scientific article published in May 2006

Insulin secretion predicts the response to therapy with exenatide plus pioglitazone, but not to basal/bolus insulin in poorly controlled T2DM patients: Results from the Qatar study

scientific article

Insulin secretion, insulin resistance, and obesity

scientific article published on 01 January 1982

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

scientific article published in September 1999

Insulin sensitivity is not impaired in Mexican-American women without a family history of diabetes.

scientific article published on June 1995

Insulin vs GLP-1 analogues in poorly controlled Type 2 diabetic subjects on oral therapy: a meta-analysis

scientific article published on 18 April 2012

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM

scientific article published on 01 March 1998

Insulin-mediated potassium uptake is normal in uremic and healthy subjects ⬇️

scientific article published on 01 February 1984

Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes

scientific article published on 01 August 1985

Investigations into the mechanisms of hyperkalemia following renal transplantation

scientific article

Irbesartan has no short-term effect on insulin resistance in hypertensive patients with additional cardiometabolic risk factors (i-RESPOND).

scientific article published on 19 November 2009

Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! GLP-1 RAs Should Replace Metformin in the Type 2 Diabetes Algorithm.

scientific article

Is glucose intolerance harmful for the uremic patient?

scientific article

Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?: The time has come for GLP-1 receptor agonists!

scientific article published on July 2013

Is insulin resistance atherogenic? Possible mechanisms

scientific article published on 30 June 2006

Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements?

scientific article published on December 1995

Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis

scientific article

Islet amyloid polypeptide response to maximal hyperglycemia and arginine is altered in impaired glucose tolerance and type 2 diabetes mellitus

scientific article published on 13 September 2016

LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training

scientific article

Lack of Effect of Pinealectomy on Ovarian Function: Evidence for a Time-Dependent Action

scientific article published on December 1, 1971

Lack of effect of parathyroid hormone on hepatic glucose metabolism in the dog ⬇️

scientific article published on 01 May 1981

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

scientific article

Leucine metabolism in IDDM. Role of insulin and substrate availability.

scientific article published in January 1990

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

scientific article published on June 1988

Linkage of type 2 diabetes on chromosome 9p24 in Mexican Americans: additional evidence from the Veterans Administration Genetic Epidemiology Study (VAGES).

scientific article published on 21 September 2013

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

scientific article published in Journal of Biological Chemistry

Localization of a major susceptibility locus influencing preterm birth

scientific article published on 20 May 2013

Lowering plasma glucose concentration by inhibiting renal sodium-glucose cotransport

scientific article published on October 2014

Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea

scientific article

Measurement of L-[1-14C]leucine kinetics in splanchnic and leg tissues in humans. Effect of amino acid infusion

scientific article published on 01 October 1988

Measurement of abdominal fat with T1-weighted MR images ⬇️

scientific article published on May 1, 1991

Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males

scientific article published on 8 December 2010

Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes

scientific article published on 11 March 2008

Mechanism of improvement in glucose metabolism after chronic glyburide therapy

scientific article published on September 1984

Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy

scientific article

Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.

scientific article published in December 1991

Mechanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes: a double-tracer study

scientific article published on 11 April 2013

Menstrual cyclicity has a profound effect on glucose homeostasis

scientific article published on 01 August 1989

Metabolic and molecular basis of insulin resistance

scientific article

Metabolic basis of obesity and noninsulin-dependent diabetes mellitus.

scientific article published in December 1988

Metabolic effects of IGF-I in diabetic rats.

scientific article

Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis

scientific article published on 01 November 1988

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.

scientific article published in November 1996

Metabolic effects of muraglitazar in type 2 diabetic subjects

scientific article published on 01 October 2011

Metabolic effects of visceral fat accumulation in type 2 diabetes

scientific article published in November 2002

Metabolic response to exercise in dialysis patients.

scientific article published in December 1987

Metabolic syndrome: definition, pathophysiology, and mechanisms

scientific article published in January 2005

Metabolic syndrome: evaluation of pathological and therapeutic outcomes

scientific article published in January 2005

Metabolites as novel biomarkers for childhood obesity-related traits in Mexican-American children.

scientific article published on 18 November 2014

Metformin-associated lactic acidosis: Current perspectives on causes and risk

scientific article

Micronized estradiol and progesterone: effects on carbohydrate metabolism in reproductive-age women

scientific article published on July 1995

Mild Physiologic Hyperglycemia Induces Hepatic Insulin Resistance in Healthy Normal Glucose-Tolerant Participants

scientific article published on 01 July 2019

Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose

scientific article

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

scientific article published on June 2008

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants

scientific article published on 30 January 2009

Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test

scientific article published on 13 August 2007

Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice

scientific article

More on the pathogenesis and management of hyponatremia in the crisis of sickle cell disease

scientific article published on December 1, 1976

Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test.

scientific article published in January 2007

Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals

scientific article published on 08 August 2006

NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions

scientific article

Na+/Li+ and Na+/H+ countertransport activity in hypertensive non-insulin-dependent diabetic patients: role of insulin resistance and antihypertensive treatment.

scientific article published in November 1997

Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats

scientific article published on 01 July 1998

Nephropathy in diabetes

scientific article published in January 2004

New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus ⬇️

scientific article published on January 17, 1983

Newly Discovered Abnormal Glucose Tolerance in Patients With Acute Myocardial Infarction and Cardiovascular Outcomes: A Meta-analysis

scientific article published on 01 August 2020

No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man

scientific article published on 01 March 1990

Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

scientific article published on 10 May 2013

Nonuremic diabetic hyperkalemia. Possible role of insulin deficiency

scientific article published on 01 July 1977

Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion

scientific article published on 01 May 1976

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

scientific article

Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states.

scientific article

Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy

scientific article published on November 1984

Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes

scientific article published in February 2002

Novel Agents for the Treatment of Type 2 Diabetes

scientific article published in May 2014

Novel hypothesis to explain why SGLT2 inhibitors inhibit only 30-50% of filtered glucose load in humans

scientific article

Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet

scientific article published on 30 March 2015

Obesity and insulin resistance in humans: a dose-response study.

scientific article published in May 1990

Obesity is associated with impaired insulin-mediated potassium uptake.

scientific article

Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19.

scientific article

Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials

scientific article published on 23 May 2016

One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes

scientific article published on 16 May 2008

Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al.

scientific article published in July 2009

Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals.

scientific article published in May 1984

Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients.

scientific article published in August 1988

PROactive: time for a critical appraisal

scientific article published on 28 March 2008

Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

scientific article published on 30 July 2009

Parental transmission of type 2 diabetes mellitus in a highly endogamous population.

scientific article published on April 2013

Pathogenesis of NIDDM. A balanced overview

scientific article published in March 1992

Pathogenesis of glucose intolerance in uremia

scientific article published on December 1, 1978

Pathogenesis of insulin resistance in skeletal muscle

scientific article

Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview

scientific article published on April 1, 1992

Pathogenesis of type 2 diabetes mellitus

scientific article published in July 2004

Pathogenesis of type 2 diabetes: implications for metformin

scientific article published on 01 January 1999

Pathophysiologic approach to hyponatremia

scientific article published on 01 July 1980

Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes

scientific article published on August 2013

Pathophysiology of prediabetes

scientific article published on June 2009

Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo

scientific article

Peripheral insulin resistance and impaired insulin signaling contribute to abnormal glucose metabolism in preterm baboons

scientific article

Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum

scientific article published on June 2013

Pharmacologic therapy for type 2 diabetes mellitus

scientific article

Pharmacologic therapy for type 2 diabetes mellitus

scientific article published on 01 July 2000

Physical training and insulin sensitivity.

scientific article

Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.

scientific article published in May 2001

Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes.

scientific article published on 28 August 2017

Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment

scientific article

Pioglitazone for diabetes prevention in impaired glucose tolerance

scientific article published in March 2011

Pioglitazone improvement of fasting and postprandial hyperglycaemia in Mexican-American patients with Type 2 diabetes: a double tracer OGTT study

scientific article published on 23 April 2010

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

scientific article

Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes

scientific article published on 17 December 2016

Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance

scientific article published on September 2016

Pioglitazone prevents the increase in plasma ketone concentration associated with dapagliflozin in insulin-treated T2DM patients: Results from the Qatar Study

scientific article published on 25 October 2018

Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes

scientific article published in June 2003

Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors

scientific article

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

scientific article published on 24 January 2009

Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study (PROactive19).

scientific article published on 17 March 2010

Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

scientific article published on 01 February 2019

Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment.

scientific article published in November 1997

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

scientific article

Plasma glucose concentration and prediction of future risk of type 2 diabetes

scientific article

Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients

scientific article published on 01 June 2004

Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus

scientific article published in April 2013

Positioning SGLT2 Inhibitors/Incretin-Based Therapies in the Treatment Algorithm

scientific article

Practical implementation of incretin-based therapy in hospitalized patients with type 2 diabetes

scientific article published on 30 December 2014

Prediabetes and risk of diabetes and associated complications: impaired fasting glucose versus impaired glucose tolerance: does it matter?

scientific article published on 6 July 2016

Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk

scientific article published on 23 September 2013

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons

scientific article published on 23 April 2009

Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance

scientific article published on 23 July 2003

Preservation of β-cell function: the key to diabetes prevention

scientific article published on 22 June 2011

Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates

scientific article published on 17 July 2013

Proceedings: Cyclophosphamide and the kidney

scientific article published on February 1974

Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue

scientific article published on 01 August 1997

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

scientific article published in January 1990

Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans

scientific article published on April 1987

Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance

scientific article published on 01 September 1995

Reduced Skeletal Muscle Phosphocreatine Concentration in Type 2 Diabetic Patients: A Quantitative Image-Based Phosphorus-31 MR Spectroscopy Study.

scientific article

Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training

scientific article published in March 2006

Reduced time points to calculate the composite index

scientific article published in July 2010

Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.

scientific article published on 30 June 2006

Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance

scientific article

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man ⬇️

scientific article published on 01 January 1983

Regulation of amino acid metabolism by epinephrine

scientific article published on 01 May 1990

Regulation of extrarenal potassium homeostasis by adrenal hormones in rats

scientific article published on 01 June 1982

Regulation of hepatic glucose metabolism in humans

scientific article

Regulation of hexokinase II activity and expression in human muscle by moderate exercise

scientific article published on 01 February 1998

Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle

scientific article published on 01 October 1995

Regulation of renal hemodynamics by plasma amino acid and hormone concentrations.

scientific article

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects

scientific article published in May 2007

Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone.

scientific article published on 23 January 2007

Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials

scientific article published on March 2010

Removal of infused amino acids by splanchnic and leg tissues in humans

scientific article published on 01 April 1986

Renal dysfunction after treatment with isophosphamide (NSC-109724).

scientific article published in May 1974

Renal function in patients with multiple myeloma

scientific article published on March 1978

Renal sodium-glucose cotransporter inhibition in the management of type 2 diabetes mellitus

scientific article

Renal transplantation in multiple myeloma. A case report

scientific article published on 01 November 1975

Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

scientific article published on 12 December 2016

Response to comment. Is incretin-based therapy ready for the care of hospitalized patients with type 2 diabetes?

scientific article published on 01 February 2014

Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans

scientific article published on 3 February 2009

Retraction. Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man

scientific article published on 01 August 1980

Revitalization of pioglitazone: the optimum agent to be combined with a sodium-glucose co-transporter-2 inhibitor.

scientific article published on 25 February 2016

Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose.

scientific article published in July 2006

Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study

scientific article

Role of adiponectin in human skeletal muscle bioenergetics

scientific article published on July 2006

Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man.

scientific article

Role of glycated hemoglobin in the prediction of future risk of T2DM.

scientific article

Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes.

scientific article published in November 1987

Role of parathyroid hormone in the glucose intolerance of chronic renal failure

scientific article

Role of plasma arginine vasopressin in the impaired water diuresis of isolated glucocorticoid deficiency in the rat

scientific article published on 01 February 1980

Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes.

scientific article published on 23 May 2011

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

scientific article

Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle

scientific article published on 01 July 1998

Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.

scientific article published in July 1996

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

scientific article published on 12 May 2008

Rosiglitazone decreases albuminuria in type 2 diabetic patients

scientific article published on 5 September 2007

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients

scientific article published in August 2003

SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study

scientific article published on May 2016

Safety and Tolerability of Combinations of Empagliflozin and Linagliptin in Patients with Type 2 Diabetes: Pooled Data from Two Randomized Controlled Trials

scientific article published on 15 June 2018

Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia.

scientific article published in September 1981

Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis

scientific article

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats

scientific article published on 01 October 1997

Short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subjects

scientific article published on 13 March 2013

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation

scientific article published in November 2001

Skeletal muscle insulin resistance is the primary defect in type 2 diabetes

scientific article

Slope of change in HbA1c from baseline with empagliflozin compared with sitagliptin or glimepiride in patients with type 2 diabetes

scientific article published on 06 April 2018

Splanchnic amino acid and glucose metabolism during amino acid infusion in dogs

scientific article published on 01 February 1988

Splanchnic and peripheral disposal of oral glucose in man

scientific article published on 01 July 1983

Splanchnic and renal metabolism of insulin in human subjects: a dose-response study ⬇️

scientific article published on 01 June 1983

Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration

scientific article published on 01 February 1980

Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion ⬇️

scientific article published on 01 April 1983

Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects.

scientific article

Strong association between insulin-mediated glucose uptake and the 2-hour, not the fasting plasma glucose concentration, in the normal glucose tolerance range

scientific article

Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

scientific article published on 01 June 1997

Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model

scientific article

Successful treatment of prediabetes in clinical practice: targeting insulin resistance and β-cell dysfunction

scientific article

Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.

scientific article

Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes

scientific article

Synergistic interaction between exercise and insulin on peripheral glucose uptake

scientific article published on December 1981

Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats

scientific article published on 01 June 1999

Synergistic interactions of counterregulatory hormones: a mechanism for stress hyperglycemia

scientific article published on 01 January 1980

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells

scientific article

The Diabetes Control and Complications Trial Study: implications for the diabetic foot.

scientific article published on November 1994

The EMPA-REG study: What has it told us? A diabetologist's perspective

scientific article published on 21 October 2015

The GENNID Study. A resource for mapping the genes that cause NIDDM.

scientific article published in August 1996

The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies

scientific article published on 18 August 2015

The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.

scientific article published on 23 January 2007

The disposal of an oral glucose load in healthy subjects. A quantitative study

scientific article published on 01 June 1985

The disposal of an oral glucose load in patients with non-insulin-dependent diabetes

scientific article published on 01 January 1988

The disposition index does not reflect β-cell function in IGT subjects treated with pioglitazone

scientific article published on 17 June 2014

The effect of dexamethasone on renal electrolyte excretion in the adrenalectomized rat

scientific article published on 01 September 1982

The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man

scientific article published on 01 November 1982

The effect of growth hormone on glucose metabolism and insulin secretion in man

scientific article published on 01 November 1982

The effect of hyperglycemia, hyperinsulinemia, and route of glucose administration on glucose oxidation and glucose storage

scientific article published on 01 September 1982

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man ⬇️

scientific article published on April 1, 1975

The effect of insulin on renal sodium metabolism. A review with clinical implications

scientific article published on September 1981

The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization

scientific article published on 01 December 1981

The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo.

scientific article published on 7 January 2015

The effect of pioglitazone on the liver: role of adiponectin.

scientific article published in October 2006

The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes

scientific article

The effect of selective beta adrenergic blockade on glucose-induced thermogenesis in man

scientific article published on 01 June 1986

The effects of glucose and insulin on renal electrolyte transport ⬇️

scientific article published on July 1, 1976

The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

The influence of age on the renal response to water deprivation in man

scientific article published on 01 January 1976

The insulin resistance syndrome: physiological considerations

scientific article published on March 2007

The metabolic consequences of long-term human obesity

scientific article published on 01 January 1988

The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents

scientific article published on December 1, 1992

The natural history of diabetic nephropathy

scientific article published on May 1990

The ontogeny of insulin signaling in the preterm baboon model

scientific article

The pathogenesis of non-insulin-dependent diabetes: an update

scientific article published on May 1982

The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance

scientific article

The relationship between {beta}-cell function and glycated hemoglobin: results from the veterans administration genetic epidemiology study. ⬇️

scientific article

The relative contributions of insulin resistance and beta cell failure to the transition from normal to impaired glucose tolerance varies in different ethnic groups

scholarly article by Muhammad A. Abdul-Ghani et al published June 2007 in Diabetes and Metabolic Syndrome: Clinical Research and Reviews

The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man

scientific article published on 01 January 1980

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

scientific article published on January 1991

The role of growth hormone in the glucose intolerance of uremia ⬇️

scientific article published on October 1, 1979

The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia.

scientific article published on January 2012

The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

scientific article published on May 2010

The use of non-insulin anti-diabetic agents to improve glycemia without hypoglycemia in the hospital setting: focus on incretins

scientific article published on March 2014

Therapeutic strategies for type 2 diabetes mellitus patients with very high HbA1c: is insulin the only option?

scientific article published in December 2018

Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men

scientific article published on 01 July 1983

Thiazolidinediones improve beta-cell function in type 2 diabetic patients.

scientific article published on 14 November 2006

Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats

scientific article published on April 1998

Time dependence of the interaction between lipid and glucose in humans

scientific article published on 01 July 1989

Time-dependent regulation by insulin of leucine metabolism in young healthy adults

scientific article published on 01 September 1994

To: Godsland IF, Jeffs JA, Johnston DG (2004) loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166.

scientific article published on 17 August 2005

Transcriptomic identification of ADH1B as a novel candidate gene for obesity and insulin resistance in human adipose tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES)

scientific article

Transcriptomics in type 2 diabetes: Bridging the gap between genotype and phenotype

scientific article

Transient hepatic response to glucagon in man: role of insulin and hyperglycemia

scientific article published on 01 February 1982

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes

scientific article

Treatment of diabetic nephropathy: a rational approach based on its pathophysiology

scientific article published on March 1, 1991

Treatment of prediabetes

scientific article

Two-step approach for the prediction of future type 2 diabetes risk

scientific article

Type 2 diabetes can be prevented with early pharmacological intervention

scientific article

UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues

scientific article published on 01 January 1997

Ultrastructure of rat initial collecting tubule. Effect of adrenal corticosteroid treatment

scientific article published on April 1985

Urinary excretion of kappa light chains in patients with diabetes mellitus

scientific article published on 01 April 1990

Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus.

scientific article published in May 1999

Use of the splanchnic/hepatic balance technique in the study of glucose metabolism

scientific article

Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes

scientific article

Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type

scientific article published on 05 August 2009

Water Intoxication and Cyclophosphamide

scientific article published on 01 November 1973

Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation

scientific article published in June 1973

What are the pharmacotherapy options for treating prediabetes?

scientific article

What is the best predictor of future type 2 diabetes?

scientific article published on 23 March 2007

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity

scientific article published on 10 February 2009

Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?

scientific article

beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis

scientific article published on 13 October 2004

β-Adrenergic Responsive Induction of Insulin Resistance in Liver of Aging Rats

scientific article published on 26 March 2011

List of works by Ralph A. DeFronzo

1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors

A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study

A novel experimental model for human mixed acinar-ductal pancreatic cancer

A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study

A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS

AMP-activated protein kinase: Role in metabolism and therapeutic implications

ANALYSIS OF DOUBLE-TRACER GLUCOSE KINETICS IN HUMANS DURING ORAL GLUCOSE TOLERANCE TEST

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

Actos Now for the prevention of diabetes (ACT NOW) study

Acute effect of human recombinant insulin-like growth factor I on renal function in humans

Acute renal failure in multiple myeloma

Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms

Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: an index of β-cell function in obese adults

Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics ⬇️

Adrenergic modulation of potassium metabolism during exercise in normal and diabetic humans

Adrenergic modulation of potassium metabolism in uremia

Aeromonas septicemia from hepatobiliary disease

Altered hypothalamic function in response to glucose ingestion in obese humans

Amino acid and glucose metabolism in the postabsorptive state and following amino acid ingestion in the dog.

Amino acid metabolism in uremia: insights gained from normal and diabetic man.

Analysis of Metabolic Parameters as Predictors of Risk in the RENAAL Study ⬇️

Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.

Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

Association of genetic variation in ENPP1 with obesity-related phenotypes

Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans

Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake ⬇️

Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW

Bedtime insulin/daytime glipizide. Effective therapy for sulfonylurea failures in NIDDM.

Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice

Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

Bicarbonate kinetics in humans: identification and validation of a three-compartment model

Biomedical imaging research opportunities workshop IV: a white paper

Bromocriptine: a novel approach to the treatment of type 2 diabetes.

Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2017 EXECUTIVE SUMMARY.

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2018 EXECUTIVE SUMMARY.

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2016 EXECUTIVE SUMMARY.

Carbohydrate metabolism in uremia: a review ⬇️

Cardiovascular Disease and Type 2 Diabetes: Has the Dawn of a New Era Arrived?

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus

Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Chronic continuous exenatide infusion does not cause pancreatic inflammation and ductal hyperplasia in non-human primates

Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney

Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.

Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals

Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin

Clinical disorders of hyperkalemia

Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes

Combination Therapy With Exenatide Plus Pioglitazone Versus Basal/Bolus Insulin in Patients With Poorly Controlled Type 2 Diabetes on Sulfonylurea Plus Metformin: The Qatar Study

Combination Therapy with Pioglitazone/Exenatide Improves Beta Cell Function and Produces Superior Glycemic Control Compared to Basal/Bolus Insulin in Poorly Controlled T2DM: 3-Year Follow-up of the Qatar Study

Combination therapy with GLP-1 receptor agonist and SGLT2 inhibitor

Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney

Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans

Comparison of thermogenic effect of fructose and glucose in normal humans

Contribution of muscle and liver to glucose-fatty acid cycle in humans

Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose

Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats