List of works - Gareth J Inman

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

scientific article published on 12 July 2019

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

scientific article

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements.

scientific article

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum

scientific article

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent.

scientific article published on September 2000

Azathioprine: friend or foe?

scientific article published on 01 May 2019

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

scientific article

Cell growth effects of Epstein-Barr virus leader protein.

scientific article

Crosstalk between p53 and TGF-β Signalling.

scientific article published on 28 March 2012

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.

scientific article

Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling

scientific article

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

scientific article

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

scholarly article by I. I. Badshah et al published 26 October 2018 in British Journal of Dermatology

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion

scientific article published on 11 November 2010

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

scientific article

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

scientific article

Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays.

scientific article

Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity ⬇️

scientific article published on January 10, 2013

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

scientific article published on 15 May 2016

Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma

scientific article published in December 2016

Heterogeneous addiction to TGFβ signalling in recessive dystrophic epidermolysis bullosa associated cutaneous squamous cell carcinoma

scientific article published on 29 July 2020

Human papillomaviruses, tumour suppressor genes and cervical cancer

scientific article published on 01 May 1993

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

scientific article published on 25 August 2016

Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence

scientific article published on 18 November 2016

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma.

scientific article published on 14 February 2013

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

scientific article published on 9 November 2016

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

scientific article published on October 2008

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity ⬇️

scientific article published on March 27, 2012

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

scientific article

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

scientific article

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

scientific article published on 08 June 2021

Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.

scientific article published on 12 January 2012

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

scientific article published on 20 November 2018

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

scientific article published on 22 February 2018

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

scientific article

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

scientific article

Stoichiometry of active smad-transcription factor complexes on DNA

scientific article

Switching TGFβ from a tumor suppressor to a tumor promoter.

scientific article published on 19 January 2011

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.

scientific article

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

scientific article published on 16 June 2017

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

scientific article published on 13 January 2017

TSC22 in mammary gland development and breast cancer.

scientific article published on 13 May 2008

Targeting BRAF-mutant tumours with TGFBR1 inhibitors.

scientific article published on January 2017

Targeting the BCL-2 family in malignancies of germinal centre origin.

scientific article published on December 2009

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

scientific article

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma

scientific article published on 18 June 2015

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

scientific article published on 14 August 2018

The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element ⬇️

scientific article published on September 1, 1991

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

scientific article published in Nature Communications

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

scientific article published on 14 December 2012

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

scientific article published on 22 August 2017

List of works by Gareth J Inman

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements.

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum

Apoptosis induced by TGF-beta 1 in Burkitt's lymphoma cells is caspase 8 dependent but is death receptor independent.

Azathioprine: friend or foe?

BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells

Cell growth effects of Epstein-Barr virus leader protein.

Crosstalk between p53 and TGF-β Signalling.

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.

Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays.

Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity ⬇️

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma

Fatal attractions? Correlations of CXCL12-CXCR4-CXCR7 expression with disease progression in melanoma and Kaposi sarcoma

Heterogeneous addiction to TGFβ signalling in recessive dystrophic epidermolysis bullosa associated cutaneous squamous cell carcinoma

Human papillomaviruses, tumour suppressor genes and cervical cancer

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence

Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma.

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity ⬇️

Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Phosphoinositide 3-kinase/AKT/mTORC1/2 signaling determines sensitivity of Burkitt's lymphoma cells to BH3 mimetics.

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Stoichiometry of active smad-transcription factor complexes on DNA

Switching TGFβ from a tumor suppressor to a tumor promoter.

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.

TSC22 in mammary gland development and breast cancer.

Targeting BRAF-mutant tumours with TGFBR1 inhibitors.

Targeting the BCL-2 family in malignancies of germinal centre origin.

The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs

The Promise of Genomics and the Development of Targeted Therapies for Cutaneous Squamous Cell Carcinoma

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions

The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element ⬇️

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.