List of works - Alexandre Escargueil

5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line.

scientific article

ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae.

scientific article published on 26 April 2013

Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.

scientific article published on 27 March 2013

Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus.

scientific article

BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

scientific article

Catalytic topoisomerase II inhibitors in cancer therapy.

scientific article

Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status.

scientific article

DNA alkylation damage and autophagy induction.

scientific article published on 18 July 2013

Detection of IgG directed against a recombinant form of Epstein-Barr virus BALF0/1 protein in patients with nasopharyngeal carcinoma

scientific article published on 28 May 2019

Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation

scientific article published on 30 September 2019

Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents.

scientific article published on 7 June 2005

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

scientific article published on 23 March 2016

EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies.

scientific article

Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, nongenetic instability, and stress-induced adaptation

scientific article

Epstein-Barr Virus BALF0 and BALF1 Modulate Autophagy

scientific article published on 27 November 2019

Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology.

scientific article

Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides

scientific article published on 04 April 2018

Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase IIalpha is regulated directly by protein phosphatase 2A.

scientific article published on April 2007

Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors.

scientific article published on 6 December 2014

Multifaceted Study on a Cytochalasin Scaffold: Lessons on Reactivity, Multidentate Catalysis, and Anticancer Properties

scientific article published on 21 October 2018

PARPs and the DNA damage response

scientific article

Resistance mechanisms associated with altered intracellular distribution of anticancer agents.

scientific article

Talaroketals A and B, unusual bis(oxaphenalenone) spiro and fused ketals from the soil fungus Talaromyces stipitatus ATCC 10500.

scientific article published on 3 February 2016

The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.

scientific article

The catalytic activities of DNA topoisomerase II are most closely associated with the DNA cleavage/religation steps.

scientific article

Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells ⬇️

scientific article published on May 27, 2011

Unexpected talaroenamine derivatives and an undescribed polyester from the fungus Talaromyces stipitatus ATCC10500.

scientific article published on 16 September 2015

What histone code for DNA repair?

scientific article published on 20 January 2008

List of works by Alexandre Escargueil

5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line.

ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae.

Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.

Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus.

BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

Catalytic topoisomerase II inhibitors in cancer therapy.

Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status.

DNA alkylation damage and autophagy induction.

Detection of IgG directed against a recombinant form of Epstein-Barr virus BALF0/1 protein in patients with nasopharyngeal carcinoma

Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation

Down-regulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M phases and increased survival to microtubule-interacting agents.

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies.

Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, nongenetic instability, and stress-induced adaptation

Epstein-Barr Virus BALF0 and BALF1 Modulate Autophagy

Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology.

Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides

Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase IIalpha is regulated directly by protein phosphatase 2A.

Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors.

Multifaceted Study on a Cytochalasin Scaffold: Lessons on Reactivity, Multidentate Catalysis, and Anticancer Properties

PARPs and the DNA damage response

Resistance mechanisms associated with altered intracellular distribution of anticancer agents.

Talaroketals A and B, unusual bis(oxaphenalenone) spiro and fused ketals from the soil fungus Talaromyces stipitatus ATCC 10500.

The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: implications for recognition and repair of antitumor alkylators.

The catalytic activities of DNA topoisomerase II are most closely associated with the DNA cleavage/religation steps.

Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells ⬇️

Unexpected talaroenamine derivatives and an undescribed polyester from the fungus Talaromyces stipitatus ATCC10500.

What histone code for DNA repair?