List of works - Afaf Helmy El-Sagheer

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

scientific article published on 01 April 2020

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

scientific article published in 2021

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

scientific article published on 23 October 2017

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

scientific article published on 15 April 2020

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

scientific article published on 11 December 2018

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

scientific article published on 03 June 2019

Dynamics of the 4D genome during in vivo lineage specification and differentiation

scientific article published on 01 June 2020

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

scientific article published on 24 August 2018

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures.

scientific article published in May 2018

Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

scientific article published on 06 June 2018

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

scientific article published on 22 January 2021

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

scientific article published on 08 April 2019

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

scientific article published on 01 February 2020

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers.

scientific article

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

scientific article published in May 2018

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

scientific article published on 01 September 2019

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

scientific article published on 01 March 2018

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

scientific article published on 7 February 2018

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

scientific article published on 7 December 2017

Single tube gene synthesis by phosphoramidate chemical ligation

scientific article

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

scientific article published on 21 February 2018

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

scientific article

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.

scientific article published on 14 June 2017

List of works by Afaf Helmy El-Sagheer

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

Dynamics of the 4D genome during in vivo lineage specification and differentiation

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures.

Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

Single tube gene synthesis by phosphoramidate chemical ligation

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.